supported by the National Natural Science Foundation of China(Grant no.32000491 to BHZ);projects 222300420015 and 2023DK2005 to YML;a start-up fund from Xinxiang Medical University(505483,to BHZ).
Regulatory T cells(Tregs)play pivotal roles in maintaining immune homeostasis and preventing excessive immune responses in vivo.As key players in suppressing immune reactions,they help to preserve immune tolerance and...
This work was supported in part by U.S.NIH/NCI R01 grants(CA217648,CA123088,CA099985,CA193136,CA152470);the NIH through the University of Michigan Rogel Cancer Center Grant(CA46592).
The majority of colorectal cancer patients are not responsive to immune checkpoint blockade(ICB).The interferon gamma(IFNγ)signaling pathway drives spontaneous and ICB-induced antitumor immunity.In this review,we sum...
Gain-of-function mutations in the STING-encoding gene TMEM173 are central to the pathology of the autoinflammatory disorder STING-associated vasculopathy with onset in infancy(SAVI).Furthermore,excessive activity of t...