supported by the grants from the Natural Science Foundation of Hainan Province,China(No.822MS199);the Hainan Provincial Health Commission Project(No.20A200032);the Key Science and Technology Project of Haikou City(No.2022-031);the Finance Science and Technology Project of Hainan Province(No.ZDYF2019112).
Benign prostatic hyperplasia(BPH)is the expansion of the prostategland that results in urinary symptoms.Both the epithelial-to-mesenchymaltransition(EMT)and the Wnt signaling pathway are associated with BPHpathology.I...
This study was supported by Beijing Municipal Science&Technology Commission to Huiguo Ding(Z221100007422002);Beijing Hospitals Authority Youth Programme to Shanshan Wang(QML20211701).
Background:Hepatocellular carcinoma(HCC)is a common malignant tumor with poor prognosis and high mortality worldwide.Although cystathionine-gamma-lyase(CSE)plays an important role in the development of multiple tumors...
financially supported by the National Key Research and Development Program of China(No.2021YFC2100900);the National Natural Science Foundation of China(No.32171261);the Taishan Industry Leading Talent of Shandong Province(No.tscx202211017);the Postgraduate Research&Practice Innovation Program of Jiangsu Province(No.KYCX23_2575).
Hyaluronan(HA),a natural high molecular weight polysaccharide,has extensive applications in cosmetology and medical treatment.Hyaluronan-degrading enzymes(Hyals)act as molecular scissors that cleave HA by breaking the...
the Natural Science Foundation of Shandong Province of China,No.ZR2021QH179 and ZR2020MH014.
BACKGROUND Ferroptosis can induce low retention and engraftment after mesenchymal stem cell(MSC)delivery,which is considered a major challenge to the effectiveness of MSC-based pulmonary arterial hypertension(PAH)ther...
Background Sphingosine-1-phosphate lyase insufficiency syndrome(SPLIS)or nephrotic syndrome type-14 is caused by biallelic mutations in SGPL1.Here,we conducted a systematic review to delineate the characteristics of S...
Anhui Province Central Guided Local Science and Technology Development Funding Project,No.2017070802D147;Anhui Province Key Clinical Specialist Construction Fund.
p.Tyr329fs is a cytochrome P450c17 mutation among Chinese individuals.However,data on 17-α-hydroxylase deficiency caused by cytochrome P450c17 p.Tyr329fs homozygous mutation are lacking.This paper is a case report of...
supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT and Future Planning, No. 2018R1A2B6001123 (to NYJ), No. 2018R1D1A1B07040282 (to JJ)
Hydrogen sulfide(H2S)is a gasotransmitter that acts as an antioxidant and exhibits a wide variety of cytoprotective and physiological functions in age-associated diseases.One of the major causes of age-related disease...
Combinatorial chemistry has been a focus of research activity in modern drug discovery and biotechnology. It is a concept by which a vast library of molecular diversity is synthesized and screened for target propertie...
supported by grants from the National Natural Science Foundation of China(No.30850004 and No.81170402)
This study aimed to observe changes in the hydrogen sulfide(H_2S) system in the blood and liver tissue of rats with hepatic cirrhosis at different stages by studying the effect of H_2S on the course of hyperdynamic ...