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期刊=Translational Neurodegeneration

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Tauroursodeoxycholic acid: a potential therapeutic tool in neurodegenerative diseases被引量：9: 《Translational Neurodegeneration》2022年第1期444-460,共17页Kareem Khalaf Paolo Tornese Antoniangela Cocco Alberto Albanese; Funded by the European Union’s Horizon 2020 research and innovation program under grant agreement No 755094 to AA.; Most neurodegenerative disorders are diseases of protein homeostasis, with misfolded aggregates accumulating. The neurodegenerative process is mediated by numerous metabolic pathways, most of which lead to apoptosis. ...; 关键词：Amyotrophic lateral sclerosis Alzheimer’s disease Bile acids Disease-modifying Huntington’s disease NEURODEGENERATION NEUROPROTECTION Parkinson’s disease Ursodeoxycholic acid Tauroursodeoxycholic acid

Neurodegenerative diseases:a hotbed for splicing defects and the potential therapies被引量：2: 《Translational Neurodegeneration》2021年第2期195-212,共18页Dunhui Li Craig Stewart McIntosh Frank Louis Mastaglia Steve Donald Wilton May Thandar Aung-Htut; This work was funded by the Australian National Health and Medical Research Council,grant number AP1144791.; Precursor messenger RNA(pre-mRNA)splicing is a fundamental step in eukaryotic gene expression that systematically removes non-coding regions(introns)and ligates coding regions(exons)into a continuous message(mature mR...; 关键词：Neurodegenerative diseases Parkinson’s disease Alzheimer’s disease Alternative splicing Splicing defects Antisense oligonucleotides Splice-switching Disease-modifying treatment

Disease modification and Neuroprotection in neurodegenerative disorders被引量：5: 《Translational Neurodegeneration》2017年第1期232-238,共7页Jeffrey Cummings; JC acknowledges funding from the National Institute of General Medical Sciences(Grant:P20GM109025)and support from Keep Memory Alive.; Background:Disease modifying therapies(DMTs)are urgently needed for neurodegenerative diseases(NDD)such as Alzheimer’s disease(AD)and many other disorders characterized by protein aggregation and neurodegeneration.De...; 关键词：Alzheimer’s disease Frontotemporal dementia Progressive supranuclear palsy Corticobasal degeneration Amyotropic lateral sclerosis Multiple system atrophy Disease modification Disease modifying therapy

Translational research in Huntington’s disease: opening up for disease modifying treatment: 《Translational Neurodegeneration》2013年第1期9-14,共6页Jean-Marc Burgunder; Research on the molecular mechanisms involved in Huntington’s disease,a monogenic disorder with a complex phenotype including motor,behaviour,and cognitive impairments,is advancing at a rapid path.Knowledge on severa...; 关键词：HUNTINGTON IMPAIRMENT ASSESSING

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