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MODIFYING: 作品数：196被引量：391H指数：9; 导出分析报告; 相关领域：医药卫生更多>>; 相关作者：李蕊刘磊田文颖赵琦沈贇更多>>; 相关机构：北京大学中山大学附属第三医院国防科学技术大学福建江夏学院更多>>; 相关期刊：更多>>; 相关基金：国家自然科学基金国家重点基础研究发展计划中国博士后科学基金国家重点实验室开放基金更多>>

Myopia control efficacy of peripheral defocus modifying spectacle lenses in children and adolescents:a Metaanalysis: 《International Journal of Ophthalmology(English edition)》2025年第4期723-734,共12页Hao-Bo Fan Zhi-Lin Li Xue-Min Zhang Ai-Rui Xie Qiu-Mei Wei Ting-Ting Song Jun-Guo Duan; Supported by Sichuan Province Science and Technology Plan(No.2023YFS0506);Medical Research Project of Jinniu District,Chengdu,Sichuan Province(No.JNKY2024-94);Xinglin Scholar Program at Chengdu University of Traditional Chinese Medicine(No.ZYTS2023028).; AIM:To evaluate the effects of microlens design of peripheral defocus modifying spectacle lenses(PDMSLs)and non-microlens design of PDMSLs on controlling myopia progression in children and adolescents.METHODS:A system...; 关键词：peripheral defocus spectacle lenses MYOPIA axial length META-ANALYSIS

Silkworm pupa peptide ameliorates dextran sulfate sodium-induced colitis by enhancing gut barriers and modifying gut flora: 《Food Science and Human Wellness》2025年第2期758-768,共11页Yaxi Zhou Diandian Wang Hao Duan Shiqi Zhou Jinhong Guo Yu Guo Jian Zhao Wenjie Yan; supported by the National Key Research and Development Program of China(2023YFF1103802)。; The anti-inflammatory properties of silkworm pupa peptide(SPP)have been recognized for their potential benefits in colitis treatment.However,the underlying mechanism of SPP in colitis animal models remains unclear.The...; 关键词：Silkworm pupa peptide Ulcerative colitis Intestinal barrier Gut flora Short-chain fatty acids

Modifying metabolic and immune hallmarks of cancer by a copper complex: 《Science China Chemistry》2025年第3期1051-1066,共16页Chengyan Chu Yunhua Zhang Chengyuan Qian Xiu-Zhi Yang Yicun Shang Zijian Guo Xiaoyong Wang; the National Natural Science Foundation of China (22377053,92153303,22293051);the Natural Science Foundation of Jiangsu Province (BK20202004)。; Metabolic adaptation of cancer cells is a key tactic for maintaining their tumorigenicity and viability in the tumor immune microenvironment(TIME).Concurrent modulation on the metabolic pathway and immune system could...; 关键词：cancer hallmark copper complex cuproptosis lactate metabolism IMMUNOMODULATION

Dawn of disease modifying interventions for dementia-Alzheimer syndrome:an assessment of safety and efficacy of promising candidates: 《Science Bulletin》2025年第4期444-447,共4页Liyang Liu Chaofan Geng Stefan J.Teipel Zaven Khachaturian Yi Tang; supported by National Key Research and Development Program of China(2022YFC3602600);National Natural Science Foundation of China(82220108009);Beijing Outstanding Young Scientist Program(JWZQ20240101023);STI2030-Major Projects(2021ZD0201801).; The field of therapy development for complex chronic brain disorders,which encompasses various forms of dementia including Alzheimer’s disease(AD),began to change dramatically during the last decade due to advances i...; 关键词：ALZHEIMER expanded cluster

Current perspectives and the future of disease-modifying therapies in type 1 diabetes: 《World Journal of Diabetes》2025年第1期12-21,共10页Sunetra Mondal Joseph M Pappachan; Use of immunomodulating agents to prevent the progression of autoimmuneβ-cell damage leading to type 1 diabetes mellitus(T1DM)is an interesting area for research.These include non-specific anti-inflammatory agents,im...; 关键词：Teplizumab Type 1 diabetes mellitus Disease modifying therapy β-cell function C-PEPTIDE IMMUNOTHERAPY

Gestational PFAS exposure and newborn size:The modifying effect of cord blood fatty acids: 《Environmental Science and Ecotechnology》2024年第6期294-303,共10页Chang Gao Lin Luo Yijun Fan Liyan Guo Lijuan Guo Lin Tao Fangbiao Tao De-Xiang Xu Robert A.Gibson Maria Makrides Hua Wang Yichao Huang; National Natural Science Foundation of China(82373586 and 82173484);Anhui Provincial Natural Science Foundation(2308085Y50);Education Department of Anhui Province for Excellent Young Scientist(2022AH030076);Center for Big Data and Population Health of IHM(JKS2022020).; Per-and polyfluoroalkyl substances(PFASs)can disrupt lipid metabolism,and changes in cord blood fatty acid composition have been observed in small newborns.Emerging evidence suggests that exposure to PFASs during preg...; 关键词：Per-and polyfluoroalkyl substance Gestational exposure Fetal nutrition Fatty acid status Newborn size

Associating prenatal phthalate exposure with childhood autistic traits:Investigating potential adverse outcome pathways and the modifying effects of maternal vitamin D: 《Eco-Environment & Health》2024年第4期425-435,共11页Hui Gao Cheng Zhang Beibei Zhu Menglong Geng Juan Tong Zixiang Zhan Yi Zhang De Wu Kun Huang Fangbiao Tao; supported by the Joint Funds of the National Natural Science Foundation of China (No.U22A20361);the Research Project for Outstanding Young People in Universities of Anhui Province (No.2023AH030118);the National Natural Science Foundation of China (No.82103856);funds from the MOE Key Laboratory of Population Health Across Life Cycle (No.JK20204).; The association between prenatal phthalate mixture exposure and the risk of autism spectrum disorder(ASD)in children,as well as the potential mechanism and impact of maternal vitamin D,remains unclear.We analyzed data...; 关键词：Autism spectrum disorder PHTHALATE Adverse outcome pathway Vitamin D Prospective birth cohort

Elucidating the role of precipitated phase particles in modifying creep properties of as-cast Mg-Bi/Sn-based alloys: 《Journal of Magnesium and Alloys》2024年第11期4682-4693,共12页Gang Xu Wei-li Cheng Yi-hao Luo Hui Yu Li-fei Wang Hang Li Hong-xia Wang Jin-hui Wang; National Natural Science Foundation of China(Grant Nos.51901153);Shanxi Scholarship Council of China(Grant No.2019032);Natural Science Foundation of Shanxi(Grant No.202103021224049)。; The study developed the three alloy systems with different precipitates and examined the role of precipitated phase particles in modifying the creep properties of as-cast Mg^(-1)0Bi-0.5Mn-0.5Ag(BMQ1000),Mg-5Bi-5Sn-0.5...; 关键词：Magnesium alloy Microstructural characteristics Creep properties PRECIPITATES Creep mechanism

Modifying effects and mechanisms of superfine stainless wires on microstructures and mechanical properties of ultra-high performance seawater sea-sand concrete: 《Science China(Technological Sciences)》2024年第10期3205-3220,共16页YU Feng DONG SuFen ASHOUR Ashraf DING SiQi HAN BaoGuo; supported by the National Natural Science Foundation of China(Grant Nos.52178188 and 52308236);the Natural Science Joint Foundation of Liaoning Province(Grant No.2023-BSBA-077);the Provincial-Municipal Joint Fund(Youth Fund)of Guangdong Basic and Applied Basic Research Foundation(Grant No.2023A1515110437);the Major Science and Technology Research Project of the China Building Materials Federation(Grant No.2023JBGS10-02).; Ultra-high-performance seawater sea-sand concrete(UHPSSC)presents a prospective solution to address the natural resource shortage in marine infrastructure construction.To eliminate the corrosion risk of steel fibers a...; 关键词：ultra-high performance seawater sea-sand concrete superfine stainless wire mechanical properties chloride ion content microstructure

Androgen Receptor Promotes Lung Cancer Metastasis by Modifying the miR23a-3p/EPHB2 Pathway: 《Current Medical Science》2024年第5期954-963,共10页Yan YANG Jing-wen HUANG Wei-wei YU; supported by the Zhongnanshan Medical Foundation of Guangdong Province(No.ZNSXS-20220072).; Objective This study aimed to investigate the reasons behind the lower survival rates in male lung cancer patients than in female lung cancer patients.Methods Through various techniques,such as Argonaute immunoprecipi...; 关键词：androgen receptor lung cancer metastasis miRNA-23a-3p EPHB2

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