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MODIFYING: 作品数：199被引量：396H指数：9; 导出分析报告; 相关领域：医药卫生更多>>; 相关作者：李蕊刘磊班冬梅田文颖赵琦更多>>; 相关机构：北京大学中山大学附属第三医院中国农业大学国防科学技术大学更多>>; 相关期刊：更多>>; 相关基金：国家自然科学基金国家重点基础研究发展计划中国博士后科学基金国家重点实验室开放基金更多>>

Role of PFKM lactylation in glycolysis regulation in endometrial cancer cells: 《Genes & Diseases》2025年第3期27-30,共4页Bin Wang Jian Ma Di Yang; supported by the National Natural Science Foundation of China(No.82203469);the Liaoning Province Joint Fund General Project(China)(No.2023-MSLH-166).; The incidence of endometrial cancer(EC)is increasing,particularly in high-risk cases with poor prognosis.1 Reprogramming glucose metabolism is the main feature of energy metabolism in EC cells,resulting in substantial...; 关键词：lactic acid PFKM lactylation endometrial cancer ec reprogramming glucose metabolism glycolysis regulation metabolic process tumor cells modifying key proteins

Myopia control efficacy of peripheral defocus modifying spectacle lenses in children and adolescents:a Metaanalysis: 《International Journal of Ophthalmology(English edition)》2025年第4期723-734,共12页Hao-Bo Fan Zhi-Lin Li Xue-Min Zhang Ai-Rui Xie Qiu-Mei Wei Ting-Ting Song Jun-Guo Duan; Supported by Sichuan Province Science and Technology Plan(No.2023YFS0506);Medical Research Project of Jinniu District,Chengdu,Sichuan Province(No.JNKY2024-94);Xinglin Scholar Program at Chengdu University of Traditional Chinese Medicine(No.ZYTS2023028).; AIM:To evaluate the effects of microlens design of peripheral defocus modifying spectacle lenses(PDMSLs)and non-microlens design of PDMSLs on controlling myopia progression in children and adolescents.METHODS:A system...; 关键词：peripheral defocus spectacle lenses MYOPIA axial length META-ANALYSIS

Silkworm pupa peptide ameliorates dextran sulfate sodium-induced colitis by enhancing gut barriers and modifying gut flora: 《Food Science and Human Wellness》2025年第2期758-768,共11页Yaxi Zhou Diandian Wang Hao Duan Shiqi Zhou Jinhong Guo Yu Guo Jian Zhao Wenjie Yan; supported by the National Key Research and Development Program of China(2023YFF1103802)。; The anti-inflammatory properties of silkworm pupa peptide(SPP)have been recognized for their potential benefits in colitis treatment.However,the underlying mechanism of SPP in colitis animal models remains unclear.The...; 关键词：Silkworm pupa peptide Ulcerative colitis Intestinal barrier Gut flora Short-chain fatty acids

Modifying metabolic and immune hallmarks of cancer by a copper complex: 《Science China Chemistry》2025年第3期1051-1066,共16页Chengyan Chu Yunhua Zhang Chengyuan Qian Xiu-Zhi Yang Yicun Shang Zijian Guo Xiaoyong Wang; the National Natural Science Foundation of China (22377053,92153303,22293051);the Natural Science Foundation of Jiangsu Province (BK20202004)。; Metabolic adaptation of cancer cells is a key tactic for maintaining their tumorigenicity and viability in the tumor immune microenvironment(TIME).Concurrent modulation on the metabolic pathway and immune system could...; 关键词：cancer hallmark copper complex cuproptosis lactate metabolism IMMUNOMODULATION

Improvement of strength and ductility of TC4_(p)/AZ91D magnesium matrix composites by modifying the extrusion ratio: 《Journal of Magnesium and Alloys》2025年第2期746-759,共14页Zuying Yu Kaihong Zheng Xintao Li Jun Xu Jianxin Sun Nan Zhou Fusheng Pan; the Guangdong Major Project of Basic and Applied Basic Research(2020B0301030006);the Guangdong Provincial Academy of Sciences Fund(2020GDASYL-20200101001);the Natural Science Foundation of Hubei Province,China(2023AFB1033).; In this study,AZ91D(Mg-9Al-Zn)alloys reinforced with 2 vol%TC4(Ti-6Al-4V)particles fabricated by semi-solid stir casting were extruded at different ratios,resulting in observed grain refinement effects.The research fi...; 关键词：Magnesium matrix composites Mechanical properties TC4 titanium alloy Extrusion process

Dawn of disease modifying interventions for dementia-Alzheimer syndrome:an assessment of safety and efficacy of promising candidates: 《Science Bulletin》2025年第4期444-447,共4页Liyang Liu Chaofan Geng Stefan J.Teipel Zaven Khachaturian Yi Tang; supported by National Key Research and Development Program of China(2022YFC3602600);National Natural Science Foundation of China(82220108009);Beijing Outstanding Young Scientist Program(JWZQ20240101023);STI2030-Major Projects(2021ZD0201801).; The field of therapy development for complex chronic brain disorders,which encompasses various forms of dementia including Alzheimer’s disease(AD),began to change dramatically during the last decade due to advances i...; 关键词：ALZHEIMER expanded cluster

COVID-19 vaccination in patients on biologic or targeted-synthetic disease modifying anti-rheumatic drug therapy:A multi center real-world data: 《Asian Pacific Journal of Tropical Medicine》2025年第2期77-83,共7页Tuba Demirci Yildirim Cansu Akleylek Derya Yıldırım Haluk Cinakli Selda Hakbilen Belkıs NihanCoşkun Burak Okyar ÖzlemÖzdemir Işık Rabia Pişkin Sağır Hakan Apaydın Ali Karakaş Yeşim Erez Tuba Yüceİnel Semih Gülle Abdurrahman Tufan Servet Akar Sema Yılmaz Neslihan Yılmaz Yavuz Pehlivan Gözde YıldırımÇetin AyşeÇefle Süleyman Serdar Koca Şükran Erten Ediz Dalkılıç Ayten Yazıcı GerçekŞen İsmail Sarı Ahmet Merih Birlik FatoşOnen; Objective:To assess the effectiveness of COVID-19 vaccination in patients with rheumatic diseases undergoing biologic(bDMARDs)or targeted-synthetic disease-modifying anti-rheumatic drugs(tsDMARDs).Methods:This cross-s...; 关键词：bDMARDs Rheumatic diseases VACCINATION COVID-19 Adverse events FLARES

Current perspectives and the future of disease-modifying therapies in type 1 diabetes: 《World Journal of Diabetes》2025年第1期12-21,共10页Sunetra Mondal Joseph M Pappachan; Use of immunomodulating agents to prevent the progression of autoimmuneβ-cell damage leading to type 1 diabetes mellitus(T1DM)is an interesting area for research.These include non-specific anti-inflammatory agents,im...; 关键词：Teplizumab Type 1 diabetes mellitus Disease modifying therapy β-cell function C-PEPTIDE IMMUNOTHERAPY

Gestational PFAS exposure and newborn size:The modifying effect of cord blood fatty acids: 《Environmental Science and Ecotechnology》2024年第6期294-303,共10页Chang Gao Lin Luo Yijun Fan Liyan Guo Lijuan Guo Lin Tao Fangbiao Tao De-Xiang Xu Robert A.Gibson Maria Makrides Hua Wang Yichao Huang; National Natural Science Foundation of China(82373586 and 82173484);Anhui Provincial Natural Science Foundation(2308085Y50);Education Department of Anhui Province for Excellent Young Scientist(2022AH030076);Center for Big Data and Population Health of IHM(JKS2022020).; Per-and polyfluoroalkyl substances(PFASs)can disrupt lipid metabolism,and changes in cord blood fatty acid composition have been observed in small newborns.Emerging evidence suggests that exposure to PFASs during preg...; 关键词：Per-and polyfluoroalkyl substance Gestational exposure Fetal nutrition Fatty acid status Newborn size

Associating prenatal phthalate exposure with childhood autistic traits:Investigating potential adverse outcome pathways and the modifying effects of maternal vitamin D: 《Eco-Environment & Health》2024年第4期425-435,共11页Hui Gao Cheng Zhang Beibei Zhu Menglong Geng Juan Tong Zixiang Zhan Yi Zhang De Wu Kun Huang Fangbiao Tao; supported by the Joint Funds of the National Natural Science Foundation of China (No.U22A20361);the Research Project for Outstanding Young People in Universities of Anhui Province (No.2023AH030118);the National Natural Science Foundation of China (No.82103856);funds from the MOE Key Laboratory of Population Health Across Life Cycle (No.JK20204).; The association between prenatal phthalate mixture exposure and the risk of autism spectrum disorder(ASD)in children,as well as the potential mechanism and impact of maternal vitamin D,remains unclear.We analyzed data...; 关键词：Autism spectrum disorder PHTHALATE Adverse outcome pathway Vitamin D Prospective birth cohort

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