Both Spain and China’s practices in urban design show how urban governance,local social development,and people’s needs shape a city’s landscape.IN the 20th century,China and Spain faced the common challenge of urba...
National Natural Science Foundation of China(82072600,82173146,81830054,81988101,and 91859205);Plan of the Shanghai Municipal Health Commission(2022XD036).
The incidence rate of intrahepatic cholangiocarcinoma(ICC),which has a poor prognosis,is rapidly increasing.To investigate the intratumor heterogeneity in ICC,we analyzed single-cell RNA sequencing data from the prima...
supported by the Natural Science Foundation of Zhejiang province(Grant Nos.LZ20C150001,LY21C150002);National Natural Science Foundation of China(Grant No.32202583).
The tendril is a climbing organ in cucurbits and functions in physical support and to avoid shading by neighboring vegetation.However,how cucurbits produce tendrils to obtain climbing ability is largely unknown.In thi...
supported by the Major Science and Technologyprojects of Henan Province,China(No.221100310100).
Co-altered pathways refer to the phenomenon where multiple biological pathways exhibit aberrant changes simultaneously within the same tumor sample.This phenomenon can facilitate a better understanding of the mechanis...
supported by grants from the NIH(P01DK113954,R01DK115761,R01DK117281,R01DK125480 and R01DK120858 to YX;R01DK129548 to YH);USDA/CRIS(51000-064-01S to YX);Postdoctoral Fellowship(2020AHA000POST000204188)to LT。
Glucose is the primary fuel source of the brain,and therefore glucose levels need to be tightly regulated and maintained within a small physiological range.Certainly,the body necessitates a stable supply of energy mai...
Transcriptomes comprise gene co-expression clustersor modules,showcasing distinct patterns of coordinated expression among groups of genes across independent biological samples(Serin et al.,2016).The"guilt-by-associat...
supported by grants from Deutsche Forschungsgemeinschaft(DFG)(SFB1089,SCHO 820/4-1,SCHO 820/6-1,SCHO 820/7-1,SCHO 820/5-2,and SPP1757 to S.S.,SFB1089,SPP1757,INST117215,DI853/3-5&7,and INST 217/785-1 to D.D.),the BONFOR program of the University of Bonn Medical Center(S.S.and D.D.),and UCB Pharma.
Synaptic vesicles can undergo several modes of exocytosis,endocytosis,and trafficking within individual synapses,and their fates may be linked to different vesicular protein compositions.Here,we mapped the intrasynapt...
funded by the research funding program“Ricerca Corrente 2019e2021,2021-2023”to Cristiano Simone,“Ricerca Corrente 2022-2024”to Vittoria Disciglio,“Ricerca Corrente 2022-2024”to Candida Fasano,AIRC fellowship for Italy“ID.26678-2021”to Martina Lepore Signorile,“Starting Grant”SG-2019-12371540 to Paola Sanese from the Italian Ministry of Health and the 2017 PRIN(Research Projects of National Relevance)n.2017WNKSLr-LS4 from the Italian MIUR to Cristiano Simone.
Familial adenomatous polyposis(FAP)and MUTYH-associ-ated polyposis(MAP)are colon cancer predisposition syn-dromes.FAP is an autosomal dominant inherited condition caused by germline mutations in the adenomatous polypo...
We thank Adrian Kontor for technical help with the manipulation of AML primary samples,Sarah Mueller for managing the supply of AML primary samples,Janet Matthews for assisting with the processing of patient clinical data,Ruth Osuntola for technical assistance with the mass spectrometry experiments and the FIMM High Throughput Biomedicine Unit for their expert technical support.This work was mainly funded by Cancer Research UK(C15966/A24375)with additional contribution from Blood Cancer UK(20008).All authors have read and approved the article.
Acute myeloid leukaemia(AML)patients harbouring certain chromosome abnormalities have particularly adverse prognosis.For these patients,targeted therapies have not yet made a significant clinical impact.To understand ...