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作品数:31被引量:108H指数:5
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相关作者:王小桐饶秋刘阳夏秋媛杨文星更多>>
相关机构:浙江大学南京军区南京总医院教育部四川大学更多>>
相关期刊:《Cellular & Molecular Immunology》《Frontiers in Biology》《Signal Transduction and Targeted Therapy》《Molecular Plant》更多>>
相关基金:国家自然科学基金广东省自然科学基金国家重点基础研究发展计划国家高技术研究发展计划更多>>
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When Design Defines a City
《China Today》2024年第7期38-40,共3页MARIA JOSÉMASNOU 
Both Spain and China’s practices in urban design show how urban governance,local social development,and people’s needs shape a city’s landscape.IN the 20th century,China and Spain faced the common challenge of urba...
关键词:transition. URBAN FINES 
Single-cell analysis defines LGALS1+fibroblasts that promote proliferation and migration of intrahepatic cholangiocarcinoma
《Journal of Molecular Cell Biology》2024年第6期14-27,共14页Qiqi Cao Jinxian Yang Lixuan Jiang Zhao Yang Zhecai Fan Shuzhen Chen Sibo Zhu Lei Yin Hongyang Wang Wen Wen 
National Natural Science Foundation of China(82072600,82173146,81830054,81988101,and 91859205);Plan of the Shanghai Municipal Health Commission(2022XD036).
The incidence rate of intrahepatic cholangiocarcinoma(ICC),which has a poor prognosis,is rapidly increasing.To investigate the intratumor heterogeneity in ICC,we analyzed single-cell RNA sequencing data from the prima...
关键词:single-cell RNA sequencing(scRNA-seq) intrahepatic cholangiocarcinoma(ICC) LGALS1 FIBROBLAST 
The intrinsic developmental age signal defines an age-dependent climbing behavior in cucumber
《Horticultural Plant Journal》2024年第3期797-808,共12页Zezhou Hong Xinrui Wang Zipei Fan Jiahao Wang Aiyi Yang Guochao Yan Yong He Huasen Wang Zhujun Zhu Yunmin Xu 
supported by the Natural Science Foundation of Zhejiang province(Grant Nos.LZ20C150001,LY21C150002);National Natural Science Foundation of China(Grant No.32202583).
The tendril is a climbing organ in cucurbits and functions in physical support and to avoid shading by neighboring vegetation.However,how cucurbits produce tendrils to obtain climbing ability is largely unknown.In thi...
关键词:CUCUMBER TENDRIL Age CsmiR156 CsSPL Climbing ability 
Co-alteration of Myc and RTK-RAS pathways defines a liver-metastatic propensity and immune-cold subgroup of pancreatic adenocarcinoma
《Genes & Diseases》2024年第3期47-50,共4页Yuyuan Zhang Ziyang Zu Hui Xu Siyuan Weng Yuqing Ren Quan Cheng Peng Luo Jian Zhang Zaoqu Liu Xinwei Han 
supported by the Major Science and Technologyprojects of Henan Province,China(No.221100310100).
Co-altered pathways refer to the phenomenon where multiple biological pathways exhibit aberrant changes simultaneously within the same tumor sample.This phenomenon can facilitate a better understanding of the mechanis...
关键词:adenocarcinoma elevated alteration 
Anoctamin 4 defines glucose-inhibited neurons in the ventromedial hypothalamus
《Neural Regeneration Research》2024年第6期1177-1178,共2页Longlong Tu Yanlin He Yong Xu 
supported by grants from the NIH(P01DK113954,R01DK115761,R01DK117281,R01DK125480 and R01DK120858 to YX;R01DK129548 to YH);USDA/CRIS(51000-064-01S to YX);Postdoctoral Fellowship(2020AHA000POST000204188)to LT。
Glucose is the primary fuel source of the brain,and therefore glucose levels need to be tightly regulated and maintained within a small physiological range.Certainly,the body necessitates a stable supply of energy mai...
关键词:inhibited MEDIAL ORGANS 
Corrigendum to ‘Coinheritance of germline mutations in APC and MUTYH genes defines the clinical outcome of adenomatous polyposis syndromes’ [Gene Dis (10) (2023),1187–1189]
《Genes & Diseases》2024年第2期1084-1084,共1页
Plant gene co-expression defines the biosynthetic pathway of neuroactive alkaloids
《Molecular Plant》2024年第3期372-374,共3页Fang Liu' Alisdair R.Fernie Youjun Zhang 
Transcriptomes comprise gene co-expression clustersor modules,showcasing distinct patterns of coordinated expression among groups of genes across independent biological samples(Serin et al.,2016).The"guilt-by-associat...
关键词:METABOLISM ALKALOIDS 
SV2B defines a subpopulation of synaptic vesicles
《Journal of Molecular Cell Biology》2023年第9期1-13,共13页Isabelle Paulussen Hannes Beckert Timothy FMusial Lena J.Gschossmann Julia Wolf Mathieu Schmitt Jérôme Clasadonte Georges Mairet-Coello Christian Wolff Susanne Schoch Dirk Dietrich 
supported by grants from Deutsche Forschungsgemeinschaft(DFG)(SFB1089,SCHO 820/4-1,SCHO 820/6-1,SCHO 820/7-1,SCHO 820/5-2,and SPP1757 to S.S.,SFB1089,SPP1757,INST117215,DI853/3-5&7,and INST 217/785-1 to D.D.),the BONFOR program of the University of Bonn Medical Center(S.S.and D.D.),and UCB Pharma.
Synaptic vesicles can undergo several modes of exocytosis,endocytosis,and trafficking within individual synapses,and their fates may be linked to different vesicular protein compositions.Here,we mapped the intrasynapt...
关键词:3D electron microscopy synaptic vesicles synaptic vesicle proteins ENDOCYTOSIS TRAFFICKING spatial organization 
Coinheritance of germline mutations in APC and MUTYH genes defines the clinical outcome of adenomatous polyposis syndromes
《Genes & Diseases》2023年第4期1187-1189,共3页Giovanna Forte Filomena Cariola Antonia Lucia Buonadonna Anna Filomena Guglielmi Andrea Manghisi Katia De Marco Valentina Grossi Candida Fasano Martina Lepore Signorile Paola Sanese Rosanna Bagnulo Nicoletta Resta b Vittoria Disciglio Cristiano Simone 
funded by the research funding program“Ricerca Corrente 2019e2021,2021-2023”to Cristiano Simone,“Ricerca Corrente 2022-2024”to Vittoria Disciglio,“Ricerca Corrente 2022-2024”to Candida Fasano,AIRC fellowship for Italy“ID.26678-2021”to Martina Lepore Signorile,“Starting Grant”SG-2019-12371540 to Paola Sanese from the Italian Ministry of Health and the 2017 PRIN(Research Projects of National Relevance)n.2017WNKSLr-LS4 from the Italian MIUR to Cristiano Simone.
Familial adenomatous polyposis(FAP)and MUTYH-associ-ated polyposis(MAP)are colon cancer predisposition syn-dromes.FAP is an autosomal dominant inherited condition caused by germline mutations in the adenomatous polypo...
关键词:POLYPOSIS adenomatous COLON 
Integrative phosphoproteomics defines two biologically distinct groups of KMT2A rearranged acute myeloid leukaemia with different drug response phenotypes被引量:1
《Signal Transduction and Targeted Therapy》2023年第3期1318-1331,共14页Pedro Casado Ana Rio-Machin Juho JMiettinen Findlay Bewicke-Copley Kevin Rouault-Pierre Szilvia Krizsan Alun Parsons Vinothini Rajeeve Farideh Miraki-Moud David CTaussig Csaba Bödör John Gribben Caroline Heckman Jude Fitzgibbon Pedro R.Cutillas 
We thank Adrian Kontor for technical help with the manipulation of AML primary samples,Sarah Mueller for managing the supply of AML primary samples,Janet Matthews for assisting with the processing of patient clinical data,Ruth Osuntola for technical assistance with the mass spectrometry experiments and the FIMM High Throughput Biomedicine Unit for their expert technical support.This work was mainly funded by Cancer Research UK(C15966/A24375)with additional contribution from Blood Cancer UK(20008).All authors have read and approved the article.
Acute myeloid leukaemia(AML)patients harbouring certain chromosome abnormalities have particularly adverse prognosis.For these patients,targeted therapies have not yet made a significant clinical impact.To understand ...
关键词:metabolism signature biologically 
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