POLYPHYLLIN

作品数：8被引量：35H指数：3
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相关领域：医药卫生更多>>
相关作者：刘莹郭阳吴宁波李斌更多>>
相关机构：湖北医药学院广州中医药大学东北林业大学北京中医药大学更多>>
相关期刊：《中国中药杂志》《Chinese Journal of Natural Medicines》《天然产物研究与开发》《消化肿瘤杂志（电子版）》更多>>
相关基金：国家自然科学基金重庆市自然科学基金更多>>
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PolyphyllinⅥ诱导铁死亡抑制结肠癌细胞株HT-29和SW480增殖机制研究
《消化肿瘤杂志(电子版)》2025年第1期56-64,共9页李斌 易小江 
广东省中医药管理局科研项目(20231148)。
目的 探讨重楼皂苷polyphyllin Ⅵ通过诱导铁死亡抑制结肠癌细胞株HT-29和SW480增殖的相关机制。方法 常规培养细胞株HT-29和SW480,实验分为阴性对照组、二甲基亚砜组、polyphyllin Ⅵ组(用浓度为5μmol/L polyphyllin Ⅵ处理的细胞)和p...
关键词：PolyphyllinⅥ 结肠癌 细胞株HT-29和SW480 铁死亡 
Polyphyllin Ⅰ enhances tumor necrosis factor-related apoptosis-inducing ligand-induced inhibition of human osteosarcoma cell growth via downregulating the Wnt/β-catenin pathway被引量：1
《Journal of Traditional Chinese Medicine》2024年第2期251-259,共9页CHANG Junli ZHAO Fulai SUN Xingyuan MA Xiaoping ZHAO Peng ZHOU Chujie SHI Binhao GU Wenchao WANG Yongjun YANG Yanping 
National Key R&D Program of China:Cooperating Studies on Measurement Technologies of Human Phenome and Crossscale Correlation of Phenotypic Data(No.2020YFE0201600);National Nature Science Foundation:Study on LncRNA-CCDC18-AS1 Mediated Osteosarcoma Occurrence by Activating YAP/TAZ and Tumor Microenvironment M2 TAM-dependent Lung Metastasis,and Efficacy/mechanism of Removing Blood Stasis/clearing heat/eliminating Toxic Material Principle(No.81973877);Mechanism Study on m6A Methyltransferase RBM15 Mediated YAP Epigenetic Modification to Promote Osteosarcoma Lung Metastasis through Lymphatic System and Management with Qichong Powder(No.82174408);Shanghai Collaborative Innovation Center of Industrial Transformation of Hospital TCM Preparation:Preclinical Study on the Treatment of Osteosarcoma with Qingre Jiedu Granules;Research Projects within Budget of Shanghai University of Traditional Chinese Medicine:the Research on the Mechanism of the HIPK3 Activation of Wnt/β-catenin Induction the Osteosarcoma and the Intervention of Banmao Decoction(No.2021LK047)。
OBJECTIVE:To investigate the synergistic effects of polyphyllin Ⅰ(PPⅠ)combined with tumor necrosis factorrelated apoptosis-inducing ligand(TRAIL)on the growth of osteosarcoma cells through downregulating the Wnt/β-...
关键词：OSTEOSARCOMA tumor necrosis factor-related apoptosis-inducing ligand Wnt signaling pathway BETA-CATENIN polyphyllinⅠ 
Polyphyllin D induces G2/M Cell Cycle Arrest via Dysfunction of Cholesterol Biosynthesis in Liver Cancer Cells被引量：1
《Biomedical and Environmental Sciences》2023年第1期94-98,共5页CHEN Yan Yan REN Cai Fang WEN Shi Yuan 
supported by Shanxi Province Science Foundation for Youths[No.20210302124668];the Science Research Start-up Fund for Doctor of Shanxi Province[No.SD2115]。
Liver cancer is a frequently occurring malignancy with a poor prognosis and a high mortality rate and is the second leading cause of cancer-related deaths[1]. Many chemotherapeutic drugs are extensively used to treat ...
关键词：DRUGS LIVER CANCER 
重楼皂苷A直接靶向ETS-1抑制胃癌细胞增殖并诱导凋亡的作用机制被引量：8
《中国中药杂志》2022年第6期1650-1657,共8页张亮 熊艺琏 任宇亮 刘雪文 司渊 刘莹 
国家自然科学基金项目(82072928);十堰市科技局引导性项目(21Y08,21Y09);大学生创新创业训练项目(S202110929002,202110929004);湖北省科技厅创新群体项目(2021CFA009)。
该文旨在探讨重楼皂苷A(polyphyllin A,PPA)抑制胃癌(gastric cancer,GC)的分子机制。选用SGC7901和MGC803细胞株作为细胞模型。用不同浓度的PPA处理细胞后,通过MTT法、实时无标记细胞分析技术(real time cellular analysis,RTCA)和克...
关键词：polyphyllin A 胃癌 ETS-1 增殖 凋亡 
Mycorrhizas Affect Polyphyllin Accumulation of Paris polyphylla var.yunnanensis through Promoting PpSE Expression被引量：3
《Phyton-International Journal of Experimental Botany》2021年第5期1535-1547,共13页Hailing Li Lingfeng Xu Zhuowei Li Shunxin Zhao Dongqin Guo Lu Rui Nong Zhou 
supported by the National Natural Science Foundation of China(No.81260622);Chongqing Natural Science Foundation Project(cstc2018jcyjAX0267).
Paris polyphylla var.yunnanensis is a traditional Chinese medicinal plant,in which polyphyllin as the main medicinal component is an important secondary metabolite with bioactivity.Arbuscular mycorrhizal fungi(AMF)hav...
关键词：Paris polyphylla var.yunnanensis Arbuscular mycorrhizal fungi POLYPHYLLIN 3-hydroxy-3-methylglutaryl CoA reductase(HMGR) squalene epoxidase(SE) 
重楼皂苷G通过CIP2A/PP2A信号通路抑制淋巴瘤细胞生长并促进凋亡及自噬的机制研究被引量：5
《天然产物研究与开发》2020年第10期1767-1772,共6页刘雪文 向雨晨 刘洋洋 司渊 刘莹 郭阳 
国家自然科学基金青年项目(81702930);湖北医药学院研究生启动金(2019QDJZR16);武当特色中药研究湖北省重点实验室开放课题(WDCM2019008);胚胎干细胞湖北省重点实验室开放课题(2020ESOF007)。
为探究一种从延龄草(Trillium tschonoskii Maxim)中提取的活性化合物polyphyllin G(PPG)在人淋巴瘤细胞中的抑制作用及机制,采用CCK-8和细胞计数测定法检测增殖抑制作用,通过流式细胞术和蛋白印迹检测细胞凋亡、自噬及上游机制。结果显...
关键词：淋巴瘤 polyphyllin G CIP2A 凋亡 自噬 
Inhibitory effects of polyphyllins I and VII on human cisplatin-resistant NSCLC via p53 upregulation and CIP2A/AKT/mTOR signaling axis inhibition被引量：17
《Chinese Journal of Natural Medicines》2019年第10期768-777,共10页FENG Fei-Fei CHENG Peng SUN Chao WANG Hui WANG Wei 
supported by the National Natural Science Foundation of China(No.81473485);the Natural Science Foundation of Shandong Province(No.2014ZRE27321)
Cancerous inhibitor of protein phosphatase 2A(CIP2A) is a human oncoprotein that is overexpressed in multiple kinds of cancers including non-small cell lung cancer(NSCLC). CIP2A plays an ’oncogenic nexus’ to partici...
关键词：POLYPHYLLIN I POLYPHYLLIN VII Cisplatin-resistance Non-small cell lung cancer P53 Cancerous inhibitor of protein phosphatase 2A 
Depletion of PINK1 sensitizes breast cancer cells to polyphyllin Ⅰ via mitophagy suppression and DRP1-mediated mitochondrial fission
《中国药理学与毒理学杂志》2016年第10期1074-1074,共1页LI Guo-bing FU Ruo-qiu SHEN Han-ming ZHOU Jing HU Xiao-ye LIU Yan-xia LI Yu-nong ZHANG Hong-wei LIU Xin ZHANG Yan-hao HUANG Cheng ZHANG Rong GAO Ning 
The project supported by National Natural Science Foundation of China(81402970,81402202,81402013,81202869)
OBJECTIVE To elucidate the molecular mechanism and the anti-breast cancer effect of polyphyllinⅠ,which is a natural compound extracted from Rhizoma of Paris polyphyllin.METHODS Human breast cancer cells were treated ...
关键词：polyphyllin Ⅰ PINK1 MITOPHAGY DRP1 mitochondrial fission apoptosis 
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