FIBROGENESIS

作品数：46被引量：605H指数：15
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相关领域：医药卫生更多>>
相关作者：陈志南边惠洁李浩吴佼更多>>
相关机构：第四军医大学同济大学上海中医药大学更多>>
相关期刊：《Journal of Bio-X Research》《World Journal of Gastroenterology》《肝脏》《Current Medical Science》更多>>
相关基金：国家自然科学基金河北省自然科学基金上海市教育委员会重点学科基金广西壮族自治区自然科学基金更多>>
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Rosmarinic acid attenuates hepatic fibrogenesis via suppression of hepatic stellate cell activation/proliferation and induction of apoptosis被引量：2
《Asian Pacific Journal of Tropical Medicine》2017年第5期423-432,共10页Naglaa M.El-Lakkany Walaa H.El-Maadawy Sayed H.Seif el-Din Olfat A.Hammam Salwa H.Mohamed Shahira M.Ezzat Marwa M.Safar Samira Saleh 
supported by Theodore Bilharz Research Institute(grant number:ID-MS-99/A,2012,PI:Naglaa El-Lakkany)
Objective:To investigate the antifibrotic role of rosmarinic acid(RA),a natural polyphenolic compound,on HSCs activation/proliferation and apoptosis in vitro and in vivo. Methods:The impact of RA on stellate cell line...
关键词：Hepatic fibrosis Hepatic stellate cells Rosmarinic acid APOPTOSIS PROLIFERATION Profibrogenic markers 
An HNF 1α-regulated feedback circuit modulates hepatic fibrogenesis via the crosstalk between hepatocytes and hepatic stellate cells被引量：16
《Cell Research》2015年第8期930-945,共16页Hui Qian Xing Deng Zhao-Wei Huang Ji Wei Chen-Hong Ding Ren-Xin Feng Xin Zeng Yue-Xiang Chen Jin Ding Lei Qiu Zhen-Lin Hu Xin Zhang Hong-Yang Wang Jun-Ping Zhang Wei-Fen Xie 
Acknowledgment We thank Dr Zhao-Hui Wei （TigerMed Co., Ltd., Shanghai, China） for assistance on statistical analysis. This work was supported by the National Natural Science Foundation of China （81470871 ; Key Program, 81230011; Creative Research Groups, 30921006） and Shanghai Science and Technology Committee for the Key Projects （13JC1407400）.
Hepatocytes are critical for the maintenance of liver homeostasis, but its involvement in hepatic fibrogenesis remains elusive. Hepatocyte nuclear factor 1α（HNF1α） is a liver-enriched transcription factor that pla...
关键词：Hepatocyte nuclear factor 1α liver fibrosis SH2 domain-containing phosphatase-1 microRNA feedback CROSSTALK 
Paediatric cholestatic liver disease:Diagnosis,assessment of disease progression and mechanisms of fibrogenesis被引量：7
《World Journal of Gastrointestinal Pathophysiology》2010年第2期69-84,共16页Tamara N Pereira Meagan J Walsh Peter J Lewindon Grant A Ramm 
Supported by a Project Grant from the National Health and Medical Research Council of Australia(NHMRC#496602 to GAR and PJL);Dr.Tamara Pereira is Supported by the Phillip Bushell Foundation Post-Doctoral Research Fellowship from the Gastroenterological Society of Australia;Associate Professor Grant A Ramm is Supported by a NHMRC Senior Research Fellowship(NHMRC#552409)
Cholestatic liver disease causes significant morbidity and mortality in children.The diagnosis and management of these diseases can be complicated by an inability to detect early stages of fibrosis and a lack of adequ...
关键词：CYSTIC FIBROSIS Biliary ATRESIA Liver biopsy Ultrasound HEPATIC FIBROSIS Cirrhosis HEPATIC stellatecell Bile acid CHEMOTAXIS Monocyte CHEMOTAXIS protein-1 
Dynamic expression of extracellular signal-regulated kinase in rat liver tissue during hepatic fibrogenesis被引量：16
《World Journal of Gastroenterology》2006年第39期6376-6381,共6页Xiao-Lan Zhang Jin-Ming Liu Chang-Chun Yang Yi-Lin Zheng Li Liu Zhan-Kui Wang Hui-Qing Jiang 
AIM： To investigate whether extracellular signal-regulated kinase 1 （ERK1） is activated and associated with hepatic stellate cell （HSC） proliferation in fibrotic rat liver tissue.METHODS： Rat hepatic fibrosis wa...
关键词：Extracellular signal-regulated kinase Hepatic fibrosis Hepatic stellate cells PROLIFERATION 
T cell immune response is correlated with fibrosis and inflammatory activity in hepatitis B cirrhotics被引量：14
《World Journal of Gastroenterology》2006年第19期3015-3019,共5页Jie-Ting Tang Jing-Yuan Fang Wei-Qi Gu En-Lin Li 
Supported by Shanghai Leading Academic Discipline Project,No. Y0205
AIM： TO explore the relationship among interferon-γ （IFN-γ） activity, fibrogenesis, T cell immune responses and hepatic inflammatory activity. METHODS： Peripheral blood samples from a total of 43 hepatitis B cir...
关键词：T cell immune responses Interferon-γ activity FIBROGENESIS Hepatic inflammatory activity 
Relationship between focal adhesion kinase and hepatic stellate cell proliferation during rat hepatic fibrogenesis被引量：19
《World Journal of Gastroenterology》2004年第20期3001-3005,共5页Hui-QingJiang Xiao-LanZhang LiLiu Chang-ChunYang 
Supported by the Natural Science Foundation of Hebei Province,No.301361
AIM: To investigate the dynamic expression of focal adhesion kinase (FAK) protein and FAK mRNA in fibrotic rat liver tissue, and the relationship between FAK and hepatic stellate cell (HSC) proliferation.METHODS: Rat ...
关键词：支持激酶 肝星形细胞 分芽增殖期间 老鼠 肝纤维化 
Effects of cytokines on carbon tetrachloride-induced hepatic fibrogenesis in rats被引量：67
《World Journal of Gastroenterology》2004年第1期77-81,共5页Li-JuanZhang Jie-PingYu DanLi Yue-HongHuang Zhi-XinChen Xiao-ZhongWang 
Supported by Science and Technology fund of Fujian Province,No.2003D05
AIM: To observe the possible effects of transforming growth factor (TGF) β1, interleukin (IL)-6, tumor-necrosis factor (TNF) α and IL-10 on experimental rat hepatic fibrosis. METHODS: One hundred SD rats were divide...
关键词：肝纤维化 动物模型 细胞迁移 四氯化碳 慢性肝损伤 细胞因子 
Gene-CYP11B2 expression in rat liver in hepatic fibrogenesis induced by CCl_4被引量：5
《Chinese Medical Journal》2001年第1期64-68,共5页李旭 杨希山 吴平生 孟莹 李淑梅 赖文岩 
theNationalNaturalScienceFoundationofChina (No 39870 331)
identify aldosterone synthase gene CYP11B2 mRNA expression in normal and fibrotic liver in rats and evaluate the curative effect of antisterone Methods 160 Wistar rats weighing about 250?g were divided into 4 grou...
关键词：CYP11B2 gene hepatic fibrogenesis hepatic stellate cells antisterone in situ hybridization reverse transcriptase polymerase chain reaction 
CYP11B2 expression in HSCs and its effect on hepatic fibrogenesis被引量：11
《World Journal of Gastroenterology》2000年第6期885-887,共3页Xu Li Ying Meng Xi Shan Yang Ping Sheng Wu Shu Mei Li Wen Yan Lai 
the National Natural Science Foundation of China,No.39870331.
INTRODUCTIONIt has been reported that renin-angiotensin systemexists in tissue and aldosterone can be synthesizedin extra-adrenal tissue including heart,bloodvessels and brain.Recent studies have broughtrich evidences...
关键词：HEPATIC FIBROGENESIS HEPATIC stellate cells in situ hybridization reninangiotensin system ALDOSTERONE POLYMERASE chain reaction liver cirrosis/prevention and control 
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