THIOSEMICARBAZONES

作品数：16被引量：15H指数：2
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New Copper (II), Palladium (II), and Platinum (II) 2-Acetylpyrazine Tert-Butylthiosemicarbazone Complexes: Inhibition of Human Topoisomerase IIα and Activity against Breast Cancer Cells
《Open Journal of Medicinal Chemistry》2022年第1期1-13,共13页Edward C. Lisic Sarah N. Grossarth Sarah B. Bowman Jessica L. Hill Michael W. Beck Joseph E. Deweese Xiaohua Jiang 
The new ligand, 2-acetylpyrazine-tertbutylthiosemicarbazone (APZ-tBTSC), and its Cu(II), Pd(II) and Pt(II) complexes have been synthesized. This ligand coordinates to the metal ions in a tridentate monoanionic fashion...
关键词：TOPOISOMERASE Breast Cancer α-(N)-Heterocyclic Thiosemicarbazones 
Synthesis and Anticancer Activity of a New Di-nuclear Ruthenium Arene Compound with Thiosemicarbazones
《Chinese Journal of Structural Chemistry》2020年第6期1112-1118,共7页SU Wei ZHANG Bao-Qu PENG Bing-Hua TANG Zhao-Feng LI Pei-Yuan 
supported by the National Natural Science Foundation of China (51961009,21761006);Natural Science Foundation of Guangxi Province (2017GXNSFAA198335,2018GXNSFAA281345);Guangxi Scientific and Technological Development Projects (AD17195081);“BAGUI Scholar” Program of Guangxi Province;Natural Science Foundation of Guangxi University of Chinese Medicine (2017JQ001);Guangxi First-class Discipline Chinese Materia Medica (Scientific Research of Guangxi Education Department 2018 No. 12);Research Project of Guangxi First-class Discipline (2019XK135);Project of Guangxi Key Laboratory of Zhuang and Yao Ethnic Medicine (GXZYZZ2019-4)。
A new di-nuclear ruthenium arene compound containing thiosemicarbazone ligands, [Ru(η6-cymene)(TSC)Cl]2(PF6)2(2), was synthesized and characterized by 1H NMR, HR-ESI-MS, and elemental analysis. Furthermore, the compl...
关键词：RUTHENIUM COMPOUND DFT ANTICANCER 
Synthesis and Cytotoxicity of the First Arene Ruthenium Compound Containing Two Thiosemicarbazone Ligands被引量：1
《Chinese Journal of Structural Chemistry》2019年第9期1543-1548,共6页SU Wei LUO Zhi-Jin CUI Hao TANG Zhao-Feng LI Pei-Yuan PENG Bing-Hua 
Supported by the National Natural Science Foundation of China(21761006);Guangxi Natural Science Foundation(2016GXNSFCA380013,2017GXNSFAA198335,2018GXNSFAA281345);Guangxi Scientific and Technological Development Projects(AD17195081),“BAGUI Scholar” Program of Guangxi Province of China,Guangxi Key Laboratory of Natural Polymer Chemistry and Physics and Nanning Normal University,Natural Science Foundation of Guangxi University of Chinese Medicine(2017JQ001);Natural Science Foundation of Team of Professor Shilin Yang(YSL17004);the specific subject of the dominant discipline construction of Chinese pharmacy from Guangxi University of Chinese Medicine(ZYX2017003);Guangxi Key Laboratory of Zhuang and Yao Ethnic Medicine,Collaborative Innovation Center of Zhuang and Yao Ethnic Medicine,Guangxi Key Discipline(Zhuang Pharmacology)
A Ru-arene compound containing two thiosemicarbazone ligands [(η6-p-cymene)Ru(TSC)2 Cl]Cl(1, TSC = benzophenone 4-methylthiosemicarbazone) has been synthesized and characterized by 1 H NMR, elemental analysis and HR-...
关键词：RUTHENIUM ARENE THIOSEMICARBAZONES X-ray crystal diffraction CYTOTOXICITY running head ARENE RUTHENIUM compound containing TSC 
Thiosemicarbazones Synthesized from Acetophenones: Tautomerism, Spectrometric Data, Reactivity and Theoretical Calculations
《International Journal of Analytical Mass Spectrometry and Chromatography》2019年第2期19-34,共16页Belén Gastaca Hernán Rubén Sánchez Fiorella Menestrina Maricel Caputo María de las Mercedes Schiavoni Jorge Javier Pedro Furlong 
Tautomeric forms of Thiosemicarbazones have been investigated by spectrometric methods, their chemical reactivity and theoretical calculations of the relative tautomers stabilities. The mass spectral fragmentation of ...
关键词：THIOSEMICARBAZONES TAUTOMERISM MS NMR THEORETICAL CALCULATIONS 
First identification of isatin-β-thiosemicarbazones as novel inhibitors of New Delhi metallo-β-lactamase-1： Chemical synthesis, biological evaluation and molecular simulation被引量：2
《Chinese Chemical Letters》2018年第6期899-902,共4页Guo-Qing Song Wei-Min Wang Zai-Shun Li Ying Wang Jian-Guo Wang 
supported by the “111” Project of Ministry of Education of China (No. B06005);the National Natural Science Foundation of China (No. 21672114);the National Basic Research Program of China (No. 2013CB734004)
New Delhi metallo-b-lactmase-1（NDM-1） catalyzes the hydrolysis of b-lactam antibiotics and cleaves the b-lactam ring of the molecule, conferring bacterial resistance against these medicines. In an effort to discover...
关键词：New Delhi metallo-β-lactmase-1 Isatin-β-thiosemicarbazones In vitro enzyme inhibition Molecular docking 
Cu(II) Propionyl-Thiazole Thiosemicarbazone Complexes: Crystal Structure, Inhibition of Human Topoisomerase IIα, and Activity against Breast Cancer Cells被引量：1
《Open Journal of Medicinal Chemistry》2018年第2期30-46,共17页Edward C. Lisic Victoria G. Rand Lana Ngo Patrick Kent Jeffrey Rice Deidra Gerlach Elizabeth T. Papish Xiaohua Jiang 
Two new thiosemicarbazone ligands, 2-propionylthiazole ethylthiosemicarbazone (PTZ-ETSC), and 2-propionylthiazole tert-butylthiosemicarbazone (PTZ-tBTSC), along with their two copper(II) complexes, [Cu(PTZ-ETSC)Cl] an...
关键词：TOPOISOMERASE BREAST Cancer THIOSEMICARBAZONES 
Cu(II) Benzoylpyridine Thiosemicarbazone Complexes: Inhibition of Human Topoisomerase IIα and Activity against Breast Cancer Cells被引量：1
《Open Journal of Inorganic Chemistry》2016年第2期146-154,共9页Jennifer D. Conner Wathsala Medawala Madison T. Stephens William H. Morris Joseph E. Deweese Patrick L. Kent Jeffery J. Rice Xiaohua Jiang Edward C. Lisic 
The focus of this research is on the study of a series of copper (II) benzoylpyridine thiosemicarbazone complexes. Of the six benzoylpyridine thiosemicarbazone ligands used in this study, two are reported for the firs...
关键词：Topoisomerase IIα Alpha-(N)-Heterocyclic Thiosemicarbazones Breast Cancer Cells 
SYNTHESIS AND TOXICITY ASSESSMENT OF DRUGGABLE THIOSEMICARBAZONES
《World Journal of Traditional Chinese Medicine》2015年第4期103-103,共1页Hope T.Sounouvou Urbain C.Kassehin Fernand A.Gbaguidi Jacques H.Poupaert 
Introduction:There is a renewed interest for thiosemicarbazones in terms of antimicrobial,antiviral,and antitumor activity.With notable exceptions(e.g.thiopental)thiocarbonyl-containing chemical entities are commonly ...
关键词：SYNTHESIS AND TOXICITY ASSESSMENT OF DRUGGABLE THIOSEMICARBAZONES 
GC/MS Analyses of Thiosemicarbazones Synthesized from Acetophenones: Thermal Decay and Mass Spectra Features
《International Journal of Analytical Mass Spectrometry and Chromatography》2015年第1期1-13,共13页Belén Gastaca Gastón Galletti Hernán Rubén Sánchez Reinaldo Pis Diez María de las Mercedes Schiavoni Jorge Javier Pedro Furlong 
The mass spectral fragmentation of thiosemicarbazones synthesized from acetophenones has been studied by CG/MS. These carbonyl compounds exhibit chromatographic peaks which are not observed in aliphatic analogues or t...
关键词：THIOSEMICARBAZONES Mass SPECTROMETRY ANALYSES DIMERIZATION of THIOSEMICARBAZONES 
In vivo anticancer activity of vanillin,benzophenone and acetophenone thiosemicarbazones on Swiss albino mice
《Journal of Coastal Life Medicine》2014年第10期811-816,共6页Sha Md.Shahan Shahriar Shaikh M Mohsin Ali Mele Jesmin Md.Khairul Islam Sarozit Mondal 
Supported by the Ministry of National Science,Information and Communication Technology(NSICT)of People’s Republic of Bangladesh(Grant No.:39.012.002.01.03.015.2011-271(64)dated-04-10-2011).
Objective:To study the anticancer activities of three schiff bases viz.vanillin thiosemicarbazone,benzophenone thiosemicarbazone and acetophenone thiosemicarbazone against Ehrlich ascites carcinoma(EAC)cells in Swiss ...
关键词：Anticancer activity Ehrlich ascites carcinoma cells THIOSEMICARBAZONES 
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