supported by the STI2030-Major Projects(2021ZD0203700/2021ZD0203703);the National Natural Science Foundation of China(31771151 and 32171030 to H.Y.,32100829 to D.L.);the Lingang Lab(Grant LG202104-01-03);Shanghai Municipal Science and Technology Major Project(grant No.2018SHZDZX05);the Strategic Priority Research Program of the Chinese Academy of Sciences(grant No.XDB32010200).
The orbitofrontal cortex(ORB),a region crucial for stimulus-reward association,decision-making,and flexible behaviors,extensively connects with other brain areas.However,brain-wide inputs to projection-defined ORB neu...
supported by the National Natural Science Foundation of China(32192413,32030050,and 32192412);the Special Fund for Science and Technology Innovation Strategy of Guangdong Province(2021B0909050004);the Key-Area Research and Development Program of Guangdong Province(2023B0303010002);the CAMS Innovation Fund for Medical Sciences,2019-I2M-5-082.
Dear Editor,Understanding the complex structure of the somatosensory neural network is crucial for deciphering how the brain processes sensory information.Recent advances in viral tracers,such as Herpes simplex virus(...
National Key Research and Development Program of China(2022YFC2402703);Scientific and Technological Innovation 2030 Program of China,major projects(2021ZD0200408);National Natural Science Foundation of China(32171007 and 31800880);Non-profit Central Research Institute Fund of the Chinese Academy of Medical Sciences(2018PT31041);Science and Technology Planning Project of Guangdong Province(2018B030331001);Fundamental Research Funds for the Central Universities(K20210089).
Behavioral studies play a crucial role in unraveling the mechanisms underlying brain function.Recent advances in optogenetics,neuronal typing and labeling,and circuit tracing have facilitated the dissection of the neu...
This review was supported by the National Science and Technology Innovation 2030(2021ZD0201003);the Strategic Priority Research Program of the Chinese Academy of Sciences(XDB32030200);the National Natural Science Foundation of China(31830035);the Shenzhen Key Laboratory of Viral Vectors for Biomedicine(ZDSYS20200811142401005).
Neural circuits provide an anatomical basis for functional networks.Therefore,dissecting the structure of neural circuits is essential to understanding how the brain works.Recombinant neurotropic viruses are important...
the National Key Research and Development Program of China(2021ZD0202700 and 2021ZD0202703);the National Natural Science Foundation of China(32070974).
Neurons are highly interwoven to form intricate neural circuits that underlie the diverse functions of the brain.Dissecting the anatomical organization of neural circuits is key to deciphering how the brain processes ...
Grants from the Natural Science Foundation of China(31730035,82071219,91632305,and 91949205);the Ministry of Science and Technology of China(2016YFC1305800);the Guangdong Provincial Key S&T Program(2018B030336001).
Alzheimer’s disease(AD)is the most common neurodegenerative disorder and there is currently no cure.Neural circuit dysfunction is the fundamental mechanism underlying the learning and memory deficits in patients with...
supported by the National Key Basic Research Program of China (2015CB755601);the National Natural Science Foundation of China (81427801, 81571355, and 81601206);the National Institutes of Health RF1 Funding of China (RF1MH120020-01)。
Anterograde viral tracers are powerful and essential tools for dissecting the output targets of a brain region of interest. They have been developed from herpes simplex virus 1(HSV-1) strain H129(H129), and have been ...
the Youth Innovation Promotion Association of the Chinese Academy of Sciences(Y6Y0021004).
The brain is a marvel of biological evolution,a highly complex organ including hundreds of different types of about 100 billion neurons.Understanding the structure and function of the brain is one of the most challeng...
the National Basic Research Program(973 Program)of China(2015CB755601);the Strategic Priority Research Program of the Chinese Academy of Sciences(XDB32030200);the National Natural Science Foundation of China(31771156,81661148053,91632303,31800885,31500868,31671120 and 91732304);the China Postdoctoral Science Foundation(2019M653118 and 2018M632946).
Efficient viral vectors for mapping and manipulating long-projection neuronal circuits are crucial in structural and functional studies of the brain. The SAD strain rabies virus with the glycoprotein gene deleted pseu...
supported by the National Natural Science Foundation of China (31671119 and 31871090);the Shenzhen Science and Technology Innovation Commission (JCYJ20160428164440255, JCYJ20170413162938668, JCYJ20170818155056369, and JCYJ20170307170742519);the Shenzhen Discipline Construction Project for Neurobiology (DRCSM [2016]1379);the Japan Society for the Promotion of Science KAKENHI (JP18K08494); the Japan Science and Technology Agency PRESTO (JPMJPR1784);the Ono Medical Research Foundation, and the Novartis Foundation (Japan) for the Promotion of Science
A central objective in deciphering the nervous system in health and disease is to define the connections of neurons. The propensity of neurotropic viruses to spread among synaptically-linked neurons makes them ideal f...