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作品数:417被引量:698H指数:12
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  • 期刊=Neuroscience Bulletinx
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Whole-brain Mapping of Inputs and Outputs of Specific Orbitofrontal Cortical Neurons in Mice
《Neuroscience Bulletin》2024年第11期1681-1698,共18页Yijie Zhang Wen Zhang Lizhao Wang Dechen Liu Taorong Xie Ziwei Le Xiangning Li Hui Gong Xiao-Hong Xu Min Xu Haishan Yao 
supported by the STI2030-Major Projects(2021ZD0203700/2021ZD0203703);the National Natural Science Foundation of China(31771151 and 32171030 to H.Y.,32100829 to D.L.);the Lingang Lab(Grant LG202104-01-03);Shanghai Municipal Science and Technology Major Project(grant No.2018SHZDZX05);the Strategic Priority Research Program of the Chinese Academy of Sciences(grant No.XDB32010200).
The orbitofrontal cortex(ORB),a region crucial for stimulus-reward association,decision-making,and flexible behaviors,extensively connects with other brain areas.However,brain-wide inputs to projection-defined ORB neu...
关键词:Orbitofrontal cortex Projection specific Rabies virus retrograde tracing Anterograde transsynaptic virus tracing Inhibitory neurons 
Tracing from Periphery to Cortex:Application of Herpes Simplex Virus to Somatosensory Neural Networks
《Neuroscience Bulletin》2024年第11期1739-1744,共6页Yan Chen Qin Chen Yuran Song Huadong Wang Xinyu Hu Kaikai Wang Xuanyuan Wu Fuqiang Xu Lan Bao Xu Zhang 
supported by the National Natural Science Foundation of China(32192413,32030050,and 32192412);the Special Fund for Science and Technology Innovation Strategy of Guangdong Province(2021B0909050004);the Key-Area Research and Development Program of Guangdong Province(2023B0303010002);the CAMS Innovation Fund for Medical Sciences,2019-I2M-5-082.
Dear Editor,Understanding the complex structure of the somatosensory neural network is crucial for deciphering how the brain processes sensory information.Recent advances in viral tracers,such as Herpes simplex virus(...
关键词:NEURAL networks CORTEX 
Morphological Tracing and Functional Identification of Monosynaptic Connections in the Brain:A Comprehensive Guide
《Neuroscience Bulletin》2024年第9期1364-1378,共15页Yuanyuan Li Yuanyuan Fang Kaiyuan Li Hongbin Yang Shumin Duan Li Sun 
National Key Research and Development Program of China(2022YFC2402703);Scientific and Technological Innovation 2030 Program of China,major projects(2021ZD0200408);National Natural Science Foundation of China(32171007 and 31800880);Non-profit Central Research Institute Fund of the Chinese Academy of Medical Sciences(2018PT31041);Science and Technology Planning Project of Guangdong Province(2018B030331001);Fundamental Research Funds for the Central Universities(K20210089).
Behavioral studies play a crucial role in unraveling the mechanisms underlying brain function.Recent advances in optogenetics,neuronal typing and labeling,and circuit tracing have facilitated the dissection of the neu...
关键词:Trans-monosynaptic RETROGRADE ANTEROGRADE Viral tool Neural circuit OPTOGENETICS ELECTROPHYSIOLOGY 
Viral Tools for Neural Circuit Tracing被引量:11
《Neuroscience Bulletin》2022年第12期1508-1518,共11页Qing Liu Yang Wu Huadong Wang Fan Jia Fuqiang Xu 
This review was supported by the National Science and Technology Innovation 2030(2021ZD0201003);the Strategic Priority Research Program of the Chinese Academy of Sciences(XDB32030200);the National Natural Science Foundation of China(31830035);the Shenzhen Key Laboratory of Viral Vectors for Biomedicine(ZDSYS20200811142401005).
Neural circuits provide an anatomical basis for functional networks.Therefore,dissecting the structure of neural circuits is essential to understanding how the brain works.Recombinant neurotropic viruses are important...
关键词:Neural circuit Viral tool ANTEROGRADE RETROGRADE Trans-synaptic 
Lighting Up Neural Circuits by Viral Tracing被引量:6
《Neuroscience Bulletin》2022年第11期1383-1396,共14页Liyao Qiu Bin Zhang Zhihua Gao 
the National Key Research and Development Program of China(2021ZD0202700 and 2021ZD0202703);the National Natural Science Foundation of China(32070974).
Neurons are highly interwoven to form intricate neural circuits that underlie the diverse functions of the brain.Dissecting the anatomical organization of neural circuits is key to deciphering how the brain processes ...
关键词:Viral tracing Neural circuit ANTEROGRADE RETROGRADE Transsynaptic 
Illuminating Neural Circuits in Alzheimer’s Disease被引量:7
《Neuroscience Bulletin》2021年第8期1203-1217,共15页Yang Ying Jian-Zhi Wang 
Grants from the Natural Science Foundation of China(31730035,82071219,91632305,and 91949205);the Ministry of Science and Technology of China(2016YFC1305800);the Guangdong Provincial Key S&T Program(2018B030336001).
Alzheimer’s disease(AD)is the most common neurodegenerative disorder and there is currently no cure.Neural circuit dysfunction is the fundamental mechanism underlying the learning and memory deficits in patients with...
关键词:Neural circuit Alzheimer’s disease Single cell RNA sequencing Neural circuit tracing OPTOGENETICS Chemogenetics 
HSV-1 H129-Derived Anterograde Neural Circuit Tracers:Improvements, Production, and Applications被引量:6
《Neuroscience Bulletin》2021年第5期701-719,共19页Hong Yang Feng Xiong Yi-Ge Song Hai-Fei Jiang Hai-Bin Qin Jing Zhou Sha Lu Steven FGrieco Xiangmin Xu Wen-Bo Zeng Fei Zhao Min-Hua Luo 
supported by the National Key Basic Research Program of China (2015CB755601);the National Natural Science Foundation of China (81427801, 81571355, and 81601206);the National Institutes of Health RF1 Funding of China (RF1MH120020-01)。
Anterograde viral tracers are powerful and essential tools for dissecting the output targets of a brain region of interest. They have been developed from herpes simplex virus 1(HSV-1) strain H129(H129), and have been ...
关键词:HSV-1 strain H129(H129) Anterograde transneuronal tracer Polysynaptic tracer Monosynaptic tracer PRODUCTION Application Neural circuit Neural circuit tracing 
Neuronal Network Dissection with Neurotropic Virus Tracing被引量:4
《Neuroscience Bulletin》2020年第3期199-201,共3页Xiaoping Rao Jie Wang 
the Youth Innovation Promotion Association of the Chinese Academy of Sciences(Y6Y0021004).
The brain is a marvel of biological evolution,a highly complex organ including hundreds of different types of about 100 billion neurons.Understanding the structure and function of the brain is one of the most challeng...
关键词:NEURAL hundreds FUNCTION 
Rabies Virus Pseudotyped with CVS-N2C Glycoprotein as a Powerful Tool for Retrograde Neuronal Network Tracing被引量:5
《Neuroscience Bulletin》2020年第3期202-216,共15页Xutao Zhu Kunzhang Lin Qing Liu Xinpei Yue Huijie Mi Xiaoping Huang Xiaobin He Ruiqi Wu Danhao Zheng Dong Wei Liangliang Jia Weilin Wang Anne Manyande Jie Wang Zhijian Zhang Fuqiang Xu 
the National Basic Research Program(973 Program)of China(2015CB755601);the Strategic Priority Research Program of the Chinese Academy of Sciences(XDB32030200);the National Natural Science Foundation of China(31771156,81661148053,91632303,31800885,31500868,31671120 and 91732304);the China Postdoctoral Science Foundation(2019M653118 and 2018M632946).
Efficient viral vectors for mapping and manipulating long-projection neuronal circuits are crucial in structural and functional studies of the brain. The SAD strain rabies virus with the glycoprotein gene deleted pseu...
关键词:VIRAL vector N2C GLYCOPROTEIN NEURONAL circuits RETROGRADE TRACING 
Trans-synaptic Neural Circuit-Tracing with Neurotropic Viruses被引量:12
《Neuroscience Bulletin》2019年第5期909-920,共12页Jiamin Li Taian Liu Yun Dong Kunio Kondoh Zhonghua Lu 
supported by the National Natural Science Foundation of China (31671119 and 31871090);the Shenzhen Science and Technology Innovation Commission (JCYJ20160428164440255, JCYJ20170413162938668, JCYJ20170818155056369, and JCYJ20170307170742519);the Shenzhen Discipline Construction Project for Neurobiology (DRCSM [2016]1379);the Japan Society for the Promotion of Science KAKENHI (JP18K08494); the Japan Science and Technology Agency PRESTO (JPMJPR1784);the Ono Medical Research Foundation, and the Novartis Foundation (Japan) for the Promotion of Science
A central objective in deciphering the nervous system in health and disease is to define the connections of neurons. The propensity of neurotropic viruses to spread among synaptically-linked neurons makes them ideal f...
关键词:Neurotropic virus Central nervous system Neural circuit Trans-synaptic TRACER RETROGRADE TRACING ANTEROGRADE TRACING 
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