PROHIBITIN

作品数:83被引量:160H指数:6
导出分析报告
相关作者:李祺福石松林崔毓桂冒韵东刘嘉茵更多>>
相关机构:复旦大学厦门大学江苏省人民医院广西医科大学第一附属医院更多>>
相关期刊:更多>>
相关基金:国家自然科学基金广东省医学科学技术研究基金广东省科技计划工业攻关项目福建省自然科学基金更多>>
-

检索结果分析

结果分析中...
条 记 录,以下是1-10
视图:
排序:
Interleukin-1 receptor associated kinase 2 is a functional downstream regulator of complement factor D that controls mitochondrial fitness in diabetic cardiomyopathy
《Military Medical Research》2024年第5期794-796,共3页Stanislovas S.Jankauskas Fahimeh Varzideh Pasquale Mone Urna Kansakar Francesco Di Lorenzo Angela Lombardi Gaetano Santulli 
National Institutes of Health(NIH):National Heart,Lung,and Blood Institute(NHLBI:R01-HL164772,R01-HL159062,R01-HL146691,T32-HL144456);National Institute of Diabetes and Digestive and Kidney Diseases(NIDDK:R01-DK123259,R01-DK033823);National Center for Advancing Translational Sciences(NCATS:UL1-TR002556-06,UM1-TR004400)(to Gaetano Santulli);Diabetes Action Research and Education Foundation(to Gaetano Santulli);Monique Weill-Caulier and Irma T.Hirschl Trusts(to Gaetano Santulli).
Diabetic cardiomyopathy is a disorder of the cardiac muscle that affects patients with diabetes.The exact mechanisms underlying diabetic cardiomyopathy are mostly unknown,but several factors have been implicated in th...
关键词:Adipsin Complement factor D INTERLEUKIN-1 Interleukin-1 receptor-associated kinase like 2(Irak2) Opa1 Prohibitin(PHB) 
A novel mechanism of PHB2-mediated mitophagy participating in the development of Parkinson's disease被引量:4
《Neural Regeneration Research》2024年第8期1828-1834,共7页Yongjiang Zhang Shiyi Yin Run Song Xiaoyi Lai Mengmeng Shen Jiannan Wu Junqiang Yan 
supported by the Key Science and Technology Research of Henan Province,No.222102310351(to JW);Luoyang 2022 Medical and Health Guiding Science and Technology Plan Project,No.2022057Y(to JY);Henan Medical Science and Technology Research Program Province-Ministry Co-sponsorship,No.SBGJ202002099(to JY)。
Endoplasmic reticulum stress and mitochondrial dysfunction play important roles in Parkinson s disease,but the regulato ry mechanism remains elusive.Prohibitin-2(PHB2)is a newly discove red autophagy receptor in the m...
关键词:endoplasmic reticulum dopaminergic neuron microtubule-associated protein 1 light chain 3 MITOPHAGY oxidative stress PARKIN Parkinson’s disease PKR-like endoplasmic reticulum kinase reactive oxygen species prohibitin-2 
Prohibitin 1 inhibits cell proliferation and induces apoptosis via the p53-mediated mitochondrial pathway in vitro被引量:1
《World Journal of Gastrointestinal Oncology》2024年第2期398-413,共16页Juan-Juan Shi Yi-Kai Wang Mu-Qi Wang Jiang Deng Ning Gao Mei Li Ya-Ping Li Xin Zhang Xiao-Li Jia Xiong-Tao Liu Shuang-Suo Dang Wen-Jun Wang 
the Key Research and Development Program of Shaanxi,No.2021SF-227 and No.2020SF-297;the Natural Science Basic Research Program of Shaanxi,No.2023-JC-YB-770。
BACKGROUND Prohibitin 1(PHB1)has been identified as an antiproliferative protein that is highly conserved and ubiquitously expressed,and it participates in a variety of essential cellular functions,including apoptosis...
关键词:Prohibitin 1 Hepatocellular carcinoma cells APOPTOSIS Cell cycle Mitochondrial pathway 
Subcellular distribution of prohibitin 1 in rat liver during liver regeneration and its cellular implication
《World Journal of Hepatology》2024年第1期65-74,共10页Qing-Ju Sun Tao Liu 
BACKGROUND The function of prohibitin 1(Phb1)during liver regeneration(LR)remains relatively unexplored.Our previous research identified downregulation of Phb1 in rat liver mitochondria 24 h after 70%partial hepatecto...
关键词:Prohibitin 1 Liver regeneration Subcellular proteomic analysis Mitochondrial stability Cell proliferation 
日本血吸虫PROHIBITIN 2克隆和表达及免疫保护效果评估
《中国动物传染病学报》2022年第6期83-90,共8页杨珊珊 杨静云 张旻 张倩 何静 黄明月 窦记晨 洪炀 林矫矫 傅志强 
国家自然基金(31872256);国家重点研发计划2017专项(2017YFD0501306);河南科技大学博士科研启动基金(13480069)。
为研究日本血吸虫PROHIBITIN的生物特性,利用PCR和3’RACE扩增到日本血吸虫抗增殖蛋白2(Schistosoma japonicum Prohibitin 2,Sj PHB2)基因,构建重组表达质粒pGEX-4T-1-SjPHB2,并在大肠杆菌(E.coli)中诱导表达,用Western blot检测其免...
关键词:日本血吸虫 抗增殖蛋白2 克隆 表达 
Prohibitin Protein Expression During Spermatogenesis in the Large Yellow Croaker, Larimichthys crocea
《Journal of Ocean University of China》2022年第5期1251-1264,共14页LIN Chenwen GAO Xinming NI Jie ZHANG Shengshuo LIU Cheng LUO Shengyu DU Chen ZHENG Xuebin HOU Congcong TANG Daojun ZHANG Chundan ZHU Junquan 
funded by the Natural Science Foun dation of Zhejiang Province(No.LY18C190007);the Na tural Science Foundation of China-Zhejiang Joint Fund for the Integration of Industrialization and Informatization(No.U1809212);the Natural Science Foundation of Ningbo City(No.2018A610228);the Scientific and Technical Project of Zhejiang Province(No.2021C02069-1);the Scientific and Technical Project of Ningbo City(No.2021Z002),the Scientific Research Foundation of Ningbo University(No.XYL19023);the Collaborative Innovation Center for Zhejiang Marine High-efficiency and Healthy Aquaculture,the K.C.Wong Magna Fund in Ningbo University.
Mitochondria are important for animals’fertility,and their morphologies and functions during spermatogenesis are un-der investigation.However,the molecular mechanism that regulates the mitochondrial dynamic during sp...
关键词:SPERMATOGENESIS ULTRASTRUCTURE PROHIBITIN expression pattern subcellular localization 
基于生物信息学分析prohibitin在肾透明细胞癌中的表达及意义被引量:1
《癌症进展》2022年第7期700-704,共5页杨文军 朱炜玮 
目的通过癌症基因组图谱(TCGA)数据库分析prohibitin(PHB)在肾透明细胞癌中的表达及与患者临床特征和预后的关系,为研究肾透明细胞癌的发病机制及治疗方法提供新思路。方法通过TCGA、人类蛋白质图谱(HPA)数据库检索PHB基因在人体正常组...
关键词:PROHIBITIN 肾透明细胞癌 数据库分析 生物信息学 
FOXM1通过靶向上调PHB2的转录改善线粒体功能障碍保护脂多糖诱导的肾小管上皮细胞损伤被引量:2
《河北医学》2022年第3期368-374,共7页陈娟 陈拉斯 陈丽 唐文庄 张琼果 王善志 
国家自然科学基金项目,(编号:81560124);海南省卫生健康行业科研项目,(编号:20A200165)。
目的:探究FOXM1在脂多糖(LPS)诱导的肾小管上皮细胞损伤中的作用及其可能的作用机制。方法:体外培养人肾小管上皮细胞HK-2,qRT-PCR和Western blot检测细胞FOXM1和PHB2表达;CCK-8检测细胞活力;流式细胞术检测细胞凋亡;JC-1染色检测线粒...
关键词:肾小管上皮细胞 脂多糖 Forkhead box M1 prohibitin 2 线粒体 
二氢杨梅素通过Prohibitin 2增强血管内皮细胞线粒体自噬被引量:1
《陆军军医大学学报》2022年第4期356-362,共7页胡琴 申卉 张婷 李亚斐 
国家自然科学基金青年科学基金(81803229);重庆市自然科学基金面上项目(cstc2020jcyj-msxmX0105)。
目的观察二氢杨梅素对血管内皮细胞线粒体自噬的影响,并探讨Prohibitin 2在其中的作用。方法用不同浓度(0、0.1、1、10、100μmol/L)二氢杨梅素处理人脐静脉血管内皮细胞(human umbilical vein endothelial cells, HUVECs)12 h后,流式...
关键词:血管内皮细胞 二氢杨梅素 Prohibitin 2 线粒体自噬 
多功能蛋白Prohibitin功能特性及其与心血管疾病关系的研究进展
《山东医药》2021年第23期87-90,共4页孙鑫鑫 杨迪成 袁忠祥 
国家自然科学基金资助项目(81770411);上海市卫计委面上项目(201640294)。
心血管疾病是当前威胁人类健康的常见疾病之一,其发病没有特定人群,针对心血管疾病的早期诊疗对患者预后极其重要。Prohibitin(PHB)是一种高度保守的多功能蛋白,主要表达于线粒体,参与维持线粒体的形态及功能。PHB参与调节血管平滑肌细...
关键词:心血管疾病 PHB 氧化应激 糖尿病性心肌病 心肌损伤 
检索报告 对象比较 聚类工具 使用帮助 返回顶部