IMMUNODOMINANCE

作品数：7被引量：11H指数：2
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表位结构指导免疫优势转移的HPV交叉疫苗的理性设计
《Science Bulletin》2024年第4期512-525,共14页王致萍 王大宁 陈洁 高飞 江雅楠 杨澄宇 钱兹英 池鑫 张姝玥 许钰洁 卢一涵 沈璟佳 张承宗 李瑾瑾 周立志 李婷婷 郑清炳 俞海 李少伟 夏宁邵 顾颖 
supported by the National Key Research and Development Program of China(2021YFC2301404);the National Natural Science Foundation of China(82271873);the CAMS Innovation Fund for Medical Sciences(2019RU022);the Xiamen Industry-University-Research Project(2022CXY0107);the Natural Science Foundation of Xiamen City(3502Z20227165);the Fundamental Research Funds for the Central Universities(20720220006 and 20720220004).
In vaccine development,broadly or cross-type neutralizing antibodies(bnAbs or cnAbs)are frequently targeted to enhance protection.Utilizing immunodominant antibodies could help fine-tune vaccine immunogenicity and aug...
关键词：Human papillomavirus Cross-neutralization antibody Immunodominance shift Vaccine design 
Correction:Correlative CD4 and CD8 T-cell immunodominance in humans and mice:implications for preclinical testing被引量：1
《Cellular & Molecular Immunology》2023年第12期1534-1534,共1页Tertuliano Alves Pereira Neto John Sidney Alba Grifoni Alessandro Sette 
The article"Correlative CD4 and CD8 T-cell immunodominance in humans and mice:Implications for preclinical testing",written by Tertuliano Alves Pereira Neto,John Sidney,Alba Grifoni&Alessandro Sette,was originally pub...
关键词：clinical testing DOMINANCE 
Correlative CD4 and CD8 T-cell immunodominance in humans and mice:Implications for preclinical testing
《Cellular & Molecular Immunology》2023年第11期1328-1338,共11页Tertuliano Alves Pereira Neto John Sidney Alba Grifoni Alessandro Sette 
This project has been funded in whole or in part with federal funds from the National Institute of Allergy and Infectious Diseases,National Institutes of Health,Department of Health and Human Services,under Contract No.AI168347 to A.G.and Contract No.75N93019C00065 and 75N93019C00001 to AS.
Antigen-specific T-cell recognition is restricted by Major Histocompatibility Complex(MHC)molecules,and differences between CD4 and CD8 immunogenicity in humans and animal species used in preclinical vaccine testing a...
关键词：T cells SARS-CoV-2 VACCINE Animal testing HLA 
Optimization of virtual machine placement based on constrained immune memory and immunodominance clone in IaaS cloud mode equipment training
《International Journal of Modeling, Simulation, and Scientific Computing》2017年第1期109-133,共25页Zhijia Chen Yuanchang Zhu Yanqiang Di Shaochong Feng 
Equipment Pre-research Fund of China under Grant No.9140A04030214JB34058.
In infrastructure as a service(IaaS)cloud mode equipment simulated training,to keep the resource utilization ratio in a rational high level,improve the training effect and reduce the system running cost,the problem of...
关键词：IaaS cloud mode training TVM placement constrained optimization immune memory immunodominance clone 
Carbohydrate-associated epitope-based anti-cancer drugs and vaccines被引量：1
《Advances in Bioscience and Biotechnology》2013年第9期18-23,共6页Gregory Lee Cheng-Yuan Huang Song-Nan Chow Chin-Hsiang Chien 
RP215 is one of the three thousand monoclonal antibodies (Mabs) which were generated against the OC-3-VGH ovarian cancer cell line. RP215 was shown to react with a carbohydrate-associated epitope located specifically ...
关键词：ANTI-CANCER DRUGS ANTI-CANCER Vaccines ANTI-IDIOTYPE CA215 Carbohydrate-Associated EPITOPE IMMUNODOMINANCE RP215 
Immunodominance and clonal selection inspired multiobjective clustering被引量：3
《Progress in Natural Science:Materials International》2009年第6期751-758,共8页Wenping Ma , Licheng Jiao, Maoguo Gong Key Laboratory of Intelligent Perception and Image Understanding of the Ministry of Education of China, Institute of Intelligent Information Processing, Xidian University, Xi’an 710071, China 
supported by the National Natural Science Foundation of China (Grant Nos.60703107,60703108);the National High Technology Research and Development Program (863 Program) of China (Grant Nos. 2006AA01Z107 and 2008AA12Z2475853);the National Basic Research Program (973 Program) of China(Grant No.2006CB705700);the Program for New Century Excellent Talents in University;the Program for Che-ung Kong Scholars and Innovative Research Team in University (Grant No.IRT0645)
The biological immune system is a highly parallel and distributed adaptive system. The information processing abilities of the immune system provide important insights into the field of computation. Based on immunodom...
关键词：Artificial immune systems Multiobjective optimization CLUSTERING Unsupervised learning 
Multiobjective optimization using an immunodominance and clonal selection inspired algorithm被引量：6
《Science in China(Series F)》2008年第8期1064-1082,共19页GONG MaoGuo JIAO LiCheng MA WenPing DU HaiFeng 
the National Natural Science Foundation of China(Grant Nos.60703107 and 60703108);the National High Technology Research and Development Program(863 Program) of China(Grant No.2006AA01Z107);the National Basic Research Program(973 Program) of China(Grant No.2006CB705700);the Program for Cheung Kong Scholars and Innovative Research Team in University(Grant No.IRT0645)
Based on the mechanisms of immunodominance and clonal selection theory, we propose a new multiobjective optimization algorithm, immune dominance clonal multiobjective algorithm （IDCMA）. IDCMA is unique in that its f...
关键词：multiobjective optimization IMMUNODOMINANCE clonal selection artificial immune systems evolutionaryalgorithms 
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