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ACETYL: 作品数：190被引量：325H指数：9; 导出分析报告; 相关领域：理学医药卫生更多>>; 相关作者：孙久荣宋新峰王淘淘王敏汪汉卿更多>>; 相关机构：中国科学院沈阳药科大学台湾大学华中科技大学更多>>; 相关期刊：更多>>; 相关基金：国家自然科学基金中国博士后科学基金国家重点基础研究发展计划北京市自然科学基金更多>>

Comparative proteomic analysis of plasma exosomes reveals the functional contribution of N-acetyl-alpha-glucosaminidase to Parkinson’s disease: 《Neural Regeneration Research》2025年第10期2998-3012,共15页Yuan Zhao Yidan Zhang Xin Liu Jian Zhang Ya Gao Shuyue Li Cui Chang Xiang Liu Guofeng Yang; supported by the Science and Technology(S&T)Program of Hebei Province,No.22377798D(to YZ).; Parkinson’s disease is the second most common progressive neurodegenerative disorder,and few reliable biomarkers are available to track disease progression.The proteins,DNA,mRNA,and lipids carried by exosomes reflect...; 关键词：biomarker diagnosis EXOSOMES N-acetyl-alpha-glucosaminidase Parkinson’s disease proteomic α-synuclein

Aging-induced memory loss due to decreased N1-acetyl-5-methoxykynuramine,a melatonin metabolite,in the hippocampus:a potential prophylactic agent for dementia被引量：1: 《Neural Regeneration Research》2025年第6期1705-1706,共2页Kazuki Watanabe Atsuhiko Hattori; supported by JSPS KAKENHI Grant Number JP22K11823 to AH and JP22J01508 to KW。; Melatonin(N-acetyl-5-methoxytryptamine)is known as the hormone of darkness because it is synthesized at night and involved in regulating the circadian clock.The hormone is primarily synthesized by the vertebrate pinea...; 关键词：metabolism primarily AGENT

Dietary supplementation with N‑acetyl‑L‑cysteine ameliorates hyperactivated ERK signaling in the endometrium that is linked to poor pregnancy outcomes following ovarian stimulation in pigs: 《Journal of Animal Science and Biotechnology》2025年第1期167-181,共15页Linghua Cheng Zhicheng Shi Yuan Yue Yue Wang Yusheng Qin Wei Zhao Yupei Hu Qin Li Min Guo Lei An Shumin Wang Jianhui Tian; National Natural Science Foundation of China(31930103);National Center of Technology Innovation for Pigs(NCTIP-XD/B03);Ningbo Major Science and Technology Project(2021Z112);National Key R&D Program(2022YFD1300303);Beijing Innovation Consortium of Livestock Research System BAIC05-2024.; Background Exogenous gonadotropin-controlled ovarian stimulation is the critical step in animal reproductive management,such as pig,sheep,bovine and other species.It helps synchronize ovulation or stimulate multiple o...; 关键词：ESTRADIOL GONADOTROPIN Implantation N-ACETYL-L-CYSTEINE Ovarian stimulation Uterine receptivity

Effect of acetyl L-carnitine on human retinal pigment epithelium-19 cells in hypoxic conditions: 《国际眼科杂志》2024年第10期1515-1521,共7页Ali Dal Onur Catak Murat Erdag Mehmet Canleblebici Ebru Onalan Ilay Buran; Firat大学科研中心项目(No.TF:19.41)。; AIM:To investigate the effect of acetyl-L-carnitine(ALCAR)on cell viability,morphological integrity,and vascular endothelial growth factor(VEGF)expression in human retinal pigment epithelium(ARPE-19)cells using a hypo...; 关键词：acetyl-L-carnitine(ALCAR) human retinal pigment epithelium(ARPE-19) vascular endothelial growth factor(VEGF) hypoxia-inducible factor 1(HIF-1α)

Author correction to‘3-O-Acetyl-11-keto-bboswellic acid ameliorated aberrant metabolic landscape and inhibited autophagy in glioblastoma’[Acta Pharm Sin B 10(2020)301-312]: 《Acta Pharmaceutica Sinica B》2024年第8期3783-3784,共2页Wan Li Liwen Ren Xiangjin Zheng Jinyi Liu Jinhua Wang Tengfei Ji Guanhua Du; The authors apologize for two inadvertent mistakes in Fig.5:the image of immunofluorescence of LC3B in the Vehicle group(Fig.5c)and the image of transmission electron microscope in the AKBA 10 mmol/L group(Fig.5f)were...; 关键词：CORRECTION Office image

艾绒的化学成分研究被引量：1: 《中草药》2024年第12期3949-3955,共7页雷青会靳景惠李东阳魏文君陈随清郭涛; 河南省高层次人才国际化培养项目(豫科[2021]72);河南省重大科技专项(221100310400)。; 目的对艾绒的化学成分进行研究。方法采用硅胶、ODS、MCI、Sephadex LH-20和prep HPLC等现代色谱技术对其化学成分进行分离纯化,利用MS、NMR等现代波谱技术鉴定单体化合物结构;采用脂多糖(lipopolysaccharide,LPS)诱导的小鼠巨噬细胞RAW...; 关键词：艾艾绒倍半萜类黄酮类抗炎 1R-长叶艾菊内酯 3-acetyl-iso-seco-tanapartholide 圣草酚泽兰黄素柚皮素高圣草酚

Mucopolysaccharidosis typeⅢB:a current review and exploration of the AAV therapy landscape被引量：1: 《Neural Regeneration Research》2024年第2期355-359,共5页Courtney J.Rouse Victoria N.Jensen Coy D.Heldermon; supported by Sanfilippo Children’s Foundation;Sanfilippo Fundacja;Sanfilippo Initiative;Cure Sanfilippo;Lacerta Therapeutics;NIH/NINDS R01NS102624(to CDH)。; Mucopolysaccharidoses typeⅢB is a rare genetic disorder caused by mutations in the gene that encodes for N-acetyl-alpha-glucosaminidase.This results in the aggregation of heparan sulfate polysaccharides within cell l...; 关键词：adeno-associated virus central nervous system gene therapy heparan sulfate immune response mucopolysaccharidoses type IIIB N-acetyl-alpha-glucosaminidase newborn screening

天然产物3-O-(4′-O-acetyl)-α-L-arabinopyranosyloleanolic acid的合成: 《中国药物化学杂志》2024年第1期55-60,共6页丁绍越焉玉超张连哲刘洋; 目的研究具有天然抗肿瘤活性的齐墩果酸皂苷类化合物3-O-(4′-O-acetyl)-α-L-arabinopyranosylolea-nolic acid的化学合成方法。方法先合成齐墩果酸苄酯和全苯甲酰化保护的阿拉伯糖三氯乙酰亚胺酯,将上述两个片段经糖苷化反应并脱去苯...; 关键词：齐墩果酸抗肿瘤阿拉伯糖天然皂苷乙酰化

A Computational Study of Microhydrated N-Acetyl-Phenylalaninylamide (NAPA): Kinetics and Thermodynamics: 《Computational Molecular Bioscience》2023年第4期63-74,共12页Mohammad Alauddin Mohammad Masud Parvez Mohammad Abdul Matin; The formations of [NAPA-A(H₂O)_n (n = 1, 2, 3, 4)] complexes have been studied employing DFT/wB97XD/cc-pVTZ computational level to understand the kinetics and thermodynamics for the hydration reac...; 关键词：Microhydration DFT Transition States KINETICS THERMODYNAMICS

Therapeutic Effect of Prolyl Endopeptidase Inhibitor in High-fat Diet-induced Metabolic Dysfunction-associated Fatty Liver Disease: 《Journal of Clinical and Translational Hepatology》2023年第5期1035-1049,共15页Jian-Bin Zhang Meng-Ting Li Shuang-Zhe Lin Yu-Qing Cheng Jian-Gao Fan Yuan-Wen Chen; supported by grants from the National Natural Science Foundation of China(81970511,82270620).; Background and Aims:Prolyl endopeptidase(PREP)is a serine endopeptidase that participates in many pathological processes including inflammation,oxidative stress,and autophagy.Our previous studies found that PREP knock...; 关键词：Metabolic dysfunction-associated fatty liver disease Prolyl endopeptidase KYP-2047 Proline-glycine-proline N-acetyl-seryl-aspartyl-lysylproline

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