N-ACETYL-L-CYSTEINE

作品数：14被引量：35H指数：3
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相关领域：医药卫生更多>>
相关机构：首都医科大学更多>>
相关期刊：《Journal of Animal Science and Biotechnology》《Science China(Life Sciences)》《Acta Pharmacologica Sinica》《World Journal of Gastroenterology》更多>>
相关基金：国家自然科学基金上海市教育委员会重点学科基金国家重点基础研究发展计划更多>>
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Dietary supplementation with N‑acetyl‑L‑cysteine ameliorates hyperactivated ERK signaling in the endometrium that is linked to poor pregnancy outcomes following ovarian stimulation in pigs
《Journal of Animal Science and Biotechnology》2025年第1期167-181,共15页Linghua Cheng Zhicheng Shi Yuan Yue Yue Wang Yusheng Qin Wei Zhao Yupei Hu Qin Li Min Guo Lei An Shumin Wang Jianhui Tian 
National Natural Science Foundation of China(31930103);National Center of Technology Innovation for Pigs(NCTIP-XD/B03);Ningbo Major Science and Technology Project(2021Z112);National Key R&D Program(2022YFD1300303);Beijing Innovation Consortium of Livestock Research System BAIC05-2024.
Background Exogenous gonadotropin-controlled ovarian stimulation is the critical step in animal reproductive management,such as pig,sheep,bovine and other species.It helps synchronize ovulation or stimulate multiple o...
关键词：ESTRADIOL GONADOTROPIN Implantation N-ACETYL-L-CYSTEINE Ovarian stimulation Uterine receptivity 
Repair of dysfunctional bone marrow endothelial cells alleviates aplastic anemia被引量：4
《Science China(Life Sciences)》2023年第11期2553-2570,共18页Shu-Qian Tang Tong Xing Zhong-Shi Lyu Li-Ping Guo Mi Liang Chen-Yuan Li Yuan-Yuan Zhang Yu Wang Lan-Ping Xu Xiao-Hui Zhang Xiao-Jun Huang Yuan Kong 
supported by the National Key Research and Development Program of China(2021YFA1100900,2022YFA1103300);the National Natural Science Foundation of China(82070188,82270229,81930004);Beijing Natural Science Foundation(7232181);Peking University People's Hospital Scientific Research Development Funds(RDGS2022-04).
Aplastic anemia(AA)is a life-threatening disease characterized by bone marrow(BM)failure and pancytopenia.As an important component of the BM microenvironment,endothelial cells(ECs)play a crucial role in supporting he...
关键词：aplastic anemia endothelial cell N-ACETYL-L-CYSTEINE hematopoietic stem cell T cell 
New N-acetyl-L-cysteine derivatives synthesized by the degradation of proanthocyanidins as high biological activity antioxidants
《Journal of Polyphenols》2021年第1期14-31,共18页Yuxuan Wang Ruifang Bai Siqi Luo Meng Huang Yan Cui 
This work was supported by Guidance Plan of Natural Science Foundation of Liaoning in China(2019-ZD-0463).
A novel degradation method was investigated to synthesize highly biologically active flavan-3-ol derivatives in the presence of N-acetyl-L-cysteine(NAC)as a nucleophile under acidic conditions for polymerized proantho...
关键词：N-ACETYL-L-CYSTEINE PROANTHOCYANIDINS HSCCC antioxidant activity 
Osthole prevents tamoxifen-induced liver injury in mice被引量：7
《Acta Pharmacologica Sinica》2019年第5期608-619,共12页Wen-bo Zhou Xin-xin Zhang Yun Cai Wu Sun Hao Li 
the National Natural Science Foundation of China (No.81270944 and No.81070678).
Tamoxifen (TMX) is an antiestrogen drug that is used in the treatment and prevention of all stages of estrogen-dependent breast cancer. Adverse effects of TMX include hepatotoxicity. In this study, we investigated the...
关键词：hepatotoxicity TAMOXIFEN oxidative stress OSTHOLE MAPK SB203580 L-buthionine SULFOXIMINE N-ACETYL-L-CYSTEINE 
S-Nitroso-N-acetyl-L-cysteine ethyl ester(SNACET) and N-acetyl-L-cysteine ethyl ester(NACET)–Cysteine-based drug candidates with unique pharmacological profiles for oral use as NO, H_2S and GSH suppliers and as antioxidants: Results and overview被引量：3
《Journal of Pharmaceutical Analysis》2018年第1期1-9,共9页Dimitrios Tsikas Kathrin S.Schwedhelm Andrzej Surdacki Daniela Giustarini Ranieri Rossi Lea Kukoc-Modun George Kedia Stefan ückert 
S-Nitrosothiols or thionitrites with the general formula RSNO are formally composed of the nitrosyl cation(NOt) and a thiolate(RSà), the base of the corresponding acids RSH. The smallest S-nitrosothiol is HSNO and de...
关键词：CGMP NITRIC oxide S-NITROSOTHIOLS Oxidative stress Pharmaceuticals 
Effect of Alteration of Glutathione Content on Cell Viability in α-Synuclein-Transfected SH-SY5Y Cells
《Advances in Parkinson's Disease》2017年第3期93-100,共8页Ken-Ichi Tanaka Kanako Sonoda Masato Asanuma 
It is well known that α-synuclein (αS) plays an important role in the pathogenesis of Parkinson’s disease (PD). Moreover, oxidative stress is also thought to be an important factor in PD due to induction of dopamin...
关键词：Α-SYNUCLEIN L-Buthionine-SR-Sulfoximine N-ACETYL-L-CYSTEINE GLUTATHIONE SH-SY5Y Cells Parkinson’s Disease 
Preventive and therapeutic effect of N-Acetyl-L-cysteine on infection-associated preterm labor in mice被引量：2
《Asian Pacific Journal of Tropical Medicine》2016年第2期195-198,共4页Ling Jiang Qian Yan Rong-Hui Liu Lu Zhang 
supported by the special plan of maternal and child health molecular genetic medicine of Maternal and Child Health Care Center in Chinese Center for Discase Control and Prevention(Grant No.FY-ZX-ZD-0059)
Objective: To study the preventive and therapeutic effect of N-Acetyl-L-cysteine on infection-associated preterm labor in mice. Methods: A total of 66 C57BL/6 inbred strain pregnant mice were selected and randomly div...
关键词：N-ACETYL-L-CYSTEINE Infection-associated preterm labor AP-1 MCP-1 NF-kappa Bp65 TNF-ALPHA 
Piperlongumine induces apoptotic and autophagic death of the primary myeloid leukemia cells from patients via activation of ROS-p38/JNK pathways被引量：14
《Acta Pharmacologica Sinica》2015年第3期362-374,共13页Xin-xin XIONG Ju-mei LIU Xin-yao QIU Feng PAN Shang-bin YU Xiao-qian CHEN 
Aim： To investigate the effects of piperlongumine （PL）, an anticancer alkaloid from long pepper plants, on the primary myeloid leukemia cells from patients and the mechanisms of action. Methods： Human BM samples w...
关键词：piperlongumine ayurvedic medicine myeloid leukemia myelodysplastic syndrome apoptosis autophagy ROS P38 JNK N-ACETYL-L-CYSTEINE SB203580 SP600125 
Fabrication of N-acetyl-L-cysteine-capped CdSe-polyelectrolytes @ Hydroxyapatite Composite Microspheres for Fluorescence Detection of Cu^(2+) Ions
《Journal of Materials Science & Technology》2013年第11期1104-1110,共7页Pengfei Li Aihua Yao Tian Zhou Deping Wang 
supported by Key Project on Basic Research of Shanghai(No.08JC1419200);the Fundamental Research Funds for the Central Universities
N-Acetyl-L-cysteine-capped CdSe-polyelectrolytes @ hydroxyapatite （NAC-CdSe-PEs@HA） composite microspheres were fabricated through a stepwise layer-by-layer method and used for fluorescence detection of Cu2＋ ions. ...
关键词：CdSe quantum dots HYDROXYAPATITE Fluorescence quenching Copper ions 
Role of oxygen free radicals in the proliferation of myofibroblasts induced by AngII
《Acta Pharmaceutica Sinica B》2013年第1期32-37,共6页Liying Wang Hong Li Shijie Yang 
This study was supported by the National Basic Research Program(also called 973 Program No.2007CB512006);the National Natural Science Foundation of China(No.30873066/C180102).
Previous studies have demonstrated the important role of angiotension II(AngII)in promoting proliferation of myofibroblasts(myoFbs)and myocardial fibrosis.However,the underlying mechanisms and the role of oxygen free ...
关键词：N-ACETYL-L-CYSTEINE ANGII Oxygen free radical MYOFIBROBLASTS Protein kinase Ca 
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