the National Key Research and Development Program of China(2016YFA0101203 to XW Bian and 2017YFC1309004 to Y Wang);the National Natural Science Foundation of China(31991172,81821003 to X.-W.Bian,81402080 to Y.-X.Wang);Chongqing Basic and Frontier Research Project(cstc2018jcyjAX0406 to Y.-X.Wang and cstc2018jcyjAX0168 to S.-Q.Lv).
Medulloblastoma(MB)is one of the most common childhood malignant brain tumors(WHO grade IV),traditionally divided into WNT,SHH,Group 3,and Group 4 subgroups based on the transcription profiles,somatic DNA alterations,...
Microvesicles (MVs) or shedding membrane vesicles have recently been described as a novel model of intercellular communication. Previously, MVs were considered as unnecessary or secreted cellular debris, but MVs have ...
supported by the National Natural Science Foundation of China,No.31000574;the Fundamental Research Fund for the Central Universities,No.78210042;the Development Program of China during the 10~(th) Five-Year Plan Period,No.2001BA70113
Signaling pathways known to have components with mutations in human medulloblastoma include sonic hedgehog, Wnt/beta-catenin and insulin-like growth factor. Microarray analysis was applied to examine the gene expressi...
Constitutive hedgehog (Hh) signaling is associated with the genesis of medulloblastomas (MB). The objective of this study is to identify special microRNAs (miRNAs) regulated by the Hh pathway, and to clarify the...
Background MicroRNAs (miRNAs) are small noncoding regulatory RNAs whose aberrant expression may be observed in many malignancies. However, few data are yet available on human primary medulloblastomas. This work aime...