Yunnan Fundamental Research Project(202305AH340006);National Natural Science Foundation of China(32201018);Basic Research Program and Key Project of Yunnan Province(202301AW070013 and 202003AD150009);Youth Innovation Promotion Association(2023403).
Hyperactivation of the NLRP3 inflammasome has been implicated in the pathogenesis of numerous diseases.However,the precise molecular mechanisms that modulate the transcriptional regulation of NLRP3 remain largely unkn...
supported by a European Regional Development Fund cofinanced grant from the Spanish Ministry of Science and Innovation(PID2019-103924GB-100);the Plan Andaluz de Investigacion,Desarrollo e Innovacion(PAIDI 2020)(P18-FR-1359);Junta de Andalucla(Group BIO192),Spain.
Nitric oxide(NO)and hydrogen sulfide(HS)are two molecules that share signaling properties in plant and animal cells NO and H2S originate two farmilies of de rived mol ecules designated reactive nitrogen and sulfur spe...
supported by the National Natural Science Foundations of China(nos.22077112,21778048,81673489,31871414,and 81125023);Natural Science Foundation of Zhejiang Province,China(no.LR18H300001);National Science and Technology Major Project“Key New Drug Creation and Manufacturing Program”(nos.2018ZX09711002-010-004,2018ZX09711002-007-002,2019ZX09201001-003-009,2019ZX09201001-003-010,and 2019ZX09201001-004-010),K.C.Wong Education Foundation,and Singapore University of Technology and Design(SUTD)[SUTD-ZJU IDEA grant nos.T1SRCI17126 and SUTD-ZJU(VP)201905].
Nitric oxide(NO)participates in various pathways and revealing its dynamics is critical for resolving its pathophysiology.While there are methods available for detecting biological NO,few are capable of tracking NO dy...
With the support by the National Natural Science Foundation of China,a study by the research groups led by Prof.Chen Chang(陈畅)from the Institute of Biophysics,Chinese Academy of Sciences demonstrates that increased ...
supported by the National Basic Research Program of China(973 Program)(Nos.2011CB910900,2012CB911000,2011CB503900);the National Natural Sciences Foundation of China(Grant No.31030023);the Knowledge Innovation Program of the Chinese Academy of Sciences.
S-Nitros(yl)ation is a ubiquitous redox-based post-translational modification of protein cysteine thiols by nitric oxide or its derivatives,which transduces the bioactivity of nitric oxide(NO)by regulation of protein ...
supported by the National Basic Research Program(973 program)of China(Grant Nos.2006CB911001,2005CB522804);the National Natural Science Foundation of China(Grant Nos.90606020 and 30770512);the Knowledge Innovation Program of the Chinese Academy of Sciences.
In this study we developed a quantitative proteomic method named ICATswitch by introducing isotope-coded affinity tag(ICAT)reagents into the biotin-switch method,and used it to investigate S-nitrosation in the liver o...