INTRANASAL

作品数：71被引量：223H指数：7
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相关作者：卜国铉韩德民张罗杨蓓蓓赵宇更多>>
相关机构：暨南大学吉林大学中日联谊医院首都医科大学浙江大学医学院附属第二医院更多>>
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Prophylactic Intranasal Treatment with Iota-Carrageenan for Acute Upper Respiratory Tract Viral Infections
《Open Journal of Respiratory Diseases》2025年第1期35-47,共13页Ronald Eccles 
The common cold is caused by a large range of respiratory viruses and is the most common disease of mankind. There is a great need for a prophylactic treatment for colds. Specific antiviral treatments are only effecti...
关键词：Iota-Carrageenan Common Cold CHILDREN TOXICOLOGY Safety 
Intranasal iron administration induces iron deposition,immunoactivation,and cell-specific vulnerability in the olfactory bulb of C57BL/6 mice
《Zoological Research》2025年第1期209-224,共16页Xiao-Qing Mi Bao-Chen Liu Le Qu Yu Yuan Hui Li Ao-Yang Xu Yu-Lin Zhang Jun-Xia Xie Ning Song 
supported by the National Natural Science Foundation of China (32471188,32170984,82301787)。
Iron is the most abundant transition metal in the brain and is essential for brain development and neuronal function;however,its abnormal accumulation is also implicated in various neurological disorders.The olfactory...
关键词：Intranasal administration Olfactory bulb IRON Ferroptosis Immune response 
Hypothalamic circuits and aging:keeping the circadian clock updated被引量：1
《Neural Regeneration Research》2024年第9期1919-1928,共10页Rosa Vázquez-Lizarraga Lucia Mendoza-Viveros Carolina Cid-Castro Sareni Ruiz-Montoya Erick Carreño-Vázquez Ricardo Orozco-Solis 
supported by National Council of Science and Technology(CONACYT)(grants FC 2016/2672 and FOSISS 272757),INMEGEN(09/2017/I);the Ministry of Education,Science,Technology and Innovation of Mexico City(SECTEI)(grant 228/2021).
Over the past century,age-related diseases,such as cancer,type-2 diabetes,obesity,and mental illness,have shown a significant increase,negatively impacting overall quality of life.Studies on aged animal models have un...
关键词：AGING ASTROCYTES cellular stress responses circadian clock HYPOTHALAMUS intranasal drug administration metabolic control nutrient sensor SIRT1 sleep homeostasis 
Intranasal adenovirus-vectored Omicron vaccine induced nasal immunoglobulin A has superior neutralizing potency than serum antibodies
《Signal Transduction and Targeted Therapy》2024年第8期3507-3518,共12页Si Chen Zhengyuan Zhang Qian Wang Qi Yang Li Yin Lishan Ning Zhilong Chen Jielin Tang Weiqi Deng Ping He Hengchun Li Linjing Shi yjun Deng Zijian Liu Hemeng Bu Yaohui Zhu Wenming Liu Linbing Qu Ligiang Feng Xiaoli Xiong Baoqing Sun Nanshan Zhong Feng Li ingchao Li Xinwen Chen Ling Chen 
The study was supported by the National Natural Science Foundation(92269201);Youth Innovation Promotion Association of CAS(2022361);Grants from Guangzhou National Laboratory(GZNL2024A01012,GZNL2023A01009);State Key Laboratory of Respiratory Disease(SKLRD-Z-202106,SKLRD-Z-202328);Science and Technology Projects in Guangzhou(SL2022A04J00604).
The upper respiratory tract is the initial site of SARS-CoV-2 infection.Nasal spike-specific secretory immunoglobulin A(slgA)correlates with protection against Omicron breakthrough infection.We report that intranasal ...
关键词：NASAL ANTIBODIES neutral 
Intranasal boosting with RBD-HR protein vaccine elicits robust mucosal and systemic immune responses
《Genes & Diseases》2024年第4期327-339,共13页Li Chen Wenyan Ren Hong Lei Jiayu Wang Haiying Que Dandan Wan Aqu Alu Dandan Peng Minyang Fu Weiqi Hong Yuhe Huang Xiangrong Song Guangwen Lu Xiawei Wei 
funded by the National Science Foundation for Excellent Young Scholars of China(No.32122052);the National Natural Science Foundation Regional Innovation and Development of China(No.U19A2003).
The emergence of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)variants has decreased the efficacy of SARs-CoV-2 vaccines in containing coronavirus disease 2019(CoVID-19)over time,and booster vaccination ...
关键词：Heterologous immunization Intranasal immunization mRNA vaccine SARS-CoV-2 Subunitprotein vaccine 
Ionic liquid-based in situ dynamically self-assembled cationic lipid nanocomplexes(CLNs)for enhanced intranasal siRNA delivery
《Chinese Chemical Letters》2024年第7期367-371,共5页Luyu Zhang Zirong Dong Shuai Yu Guangyue Li Weiwen Kong Wenjuan Liu Haisheng He Yi Lu Wei Wu Jianping Qi 
supported by National Natural Science Foundation of China(No.82073801)。
This research aims to develop a non-invasive strategy for small interfering RNA(siRNA)nasal delivery based on ionic liquids(ILs)and cationic lipid(2,3-dioleoyloxy-propyl)-trimethylammonium-chloride(DOTAP).Other than t...
关键词：Ionic liquids Cationic lipids Lipid nanoparticles siRNA Allergic rhinitis 
Research progress on intranasal treatment forParkinson'sdisease
《Neuroprotection》2024年第2期79-99,共21页Puyuan Wen Chao Ren 
National Natural Science Foundation of China,Grant/AwardNumber:82371119。
Parkinson's disease(PD)is the second most prevalent neurodegenerative disorder globally,significantly affecting the quality of life of affected individuals.Systemic drug delivery to the brain is inefficient because of...
关键词：delivery system INTRANASAL nose-to-brain Parkinson's disease TREATMENT 
Agomirs upregulating carboxypeptidase E expression rescue hippocampal neurogenesis and memory deficits in Alzheimer’s disease
《Translational Neurodegeneration》2024年第1期759-779,共21页Dongfang Jiang Hongmei Liu Tingting Li Song Zhao Keyan Yang Fuwen Yao Bo Zhou Haiping Feng Sijia Wang Jiaqi Shen Jinglan Tang Yu-Xin Zhang Yun Wang Caixia Guo Tie-Shan Tang 
supported by National Natural Science Foundation of China 82030033(T.-S.T.),81921006(T.-S.T.),92254301(T.-S.T.),82341006(C.G.),82330090(G.G.),32070780(H.L.),Beijing Natural Science Foundation IS23071(C.G.),and the State Key Laboratory of Membrane Biology。
Background Adult neurogenesis occurs in the subventricular zone(SVZ)and the subgranular zone of the dentate gyrus in the hippocampus.The neuronal stem cells in these two neurogenic niches respond differently to variou...
关键词：Carboxypeptidase E Adult hippocampal neurogenesis Agomir BDNF Alzheimer’s disease Memory deficit Intranasal instillation 
Novel Intranasal Mask Provides Potent Protection against Viral Aerosols
《Bulletin of the Chinese Academy of Sciences》2023年第4期245-246,共2页LI Xiangyu 
Researchers from the Institute of Process Engineering(IPE)of the Chinese Academy of Sciences have developed a novel intranasal mask to protect the respiratory tract from viral aerosols.It showed satisfactory protectio...
关键词：NASAL RESPIRATORY satisfactory 
Immunogenicity of mucosal COVID-19 vaccine candidates based on the highly attenuated vesicular stomatitis virus vector(VSV_(MT))in golden syrian hamster
《Acta Pharmaceutica Sinica B》2023年第12期4856-4874,共19页Yong Ke En Zhang Jianming Guo Xiaoxiao Zhang Lei Wang Duo Chen Xinkui Fang Jianwei Zhu Feng Li Tao Sun Baohong Zhang 
supported by Biomedicine and Technology Supporting Project of Shanghai Science and Technology Innovation Plan(Grant Nos.22S11902200 and 20S11904900,China);Open grant of Engineering Research Center of Cell&Therapeutic Antibody,Ministry of Education,Shanghai Jiao Tong University(Grant No.19X110020009-003,China).
COVID-19 is caused by coronavirus SARS-CoV-2.Current systemic vaccines generally pro-vide limited protection against viral replication and shedding within the airway.Recombinant VSV(rVSV)is an effective vector which i...
关键词：COVID-19 Vesicular stomatitisvirus Matrix protein mutant Mucosal Vaccine Spike protein Variants of concerns Intranasal inoculation Cellular immunity 
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