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Exosomal miR-137-3p targets UBE3C to activate STAT3,promoting migration and differentiation into endometrial epithelial cell of human umbilical cord mesenchymal stem cells under hypoxia: 《World Journal of Stem Cells》2025年第4期48-63,共16页Wan-Yu Zhang Si-Miao Liu Han-Bi Wang Cheng-Yan Deng; Supported by the National High Level Hospital Clinical Research Funding,No.2022-PUMCH-B-080 and No.2022-PUMCH-C-064.; BACKGROUND Thin endometrium,leading cause of recurrent implantation failure and infertility,has been found to respond to exosomes.AIM To investigate the efficacy of exosomes in addressing the issue of thin endometrium...; 关键词：Endometrial epithelial cells EXOSOMES miR-137-3p Ubiquitin protein ligase E3C Signal transducer and activator of transcription 3 Human umbilical cord mesenchymal stem cells

To activate a G protein-coupled receptor permanently with cell surface photodynamic action in the gastrointestinal tract: 《World Journal of Gastroenterology》2025年第12期1-13,共13页Zong-Jie Cui; Supported by the National Natural Science Foundation of China,No.32271278 and No.31971170.; Different from reversible agonist-stimulated receptor activation,singlet oxygen oxidation activates permanently G protein-coupled receptor(GPCR)cholecystokinin 1(CCK1R)in type II photodynamic action,with soluble photo...; 关键词：Cholecystokinin 1 receptor Singlet oxygen G protein-coupled receptor activated by singlet oxygen Genetically encoded protein photosensitizers Calcium oscillations Pancreatic acinar cells

Utilizing bivalent aptamers as first DNA agonist to activate RTKs heterodimer of different families: 《Chinese Chemical Letters》2025年第1期474-477,共4页Kun Liu Yulin Cong Xiongfeng Luo Meicun Yao Zhiyong Xie Hao Li; the National Natural Science Foundation of China(Nos.22104158,82174104,U1903211);the Natural Science Foundation of Hunan Province(No.2021JJ40041);Guangdong Basic and Applied Basic Research Foundation(No.2023A1515011346);Shenzhen Science and Technology Program(No.SZBH202130)。; Heterodimerization in RTKs is of vital importance in the RTK signaling and cell functions.Heterodimerization between RTKs can result in diversity of downstream signals,increasing the ability of cells to respond to ext...; 关键词：DNA Agonist Bivalent aptamers RTKs heterodimer

Gravitational and elastic energies stored in crustal volumes activate normal versus strike-slip and thrust seismogenic faults: 《Geoscience Frontiers》2024年第6期194-206,共13页Carlo Doglioni; Shallow crustal faults are passive features mobilized by the dissipation of the potential energy and the shear stress accumulated in the brittle volume surrounding them.However,the stored energy in the volume differs ...; 关键词：Pro-gravity tectonics Iso-gravity tectonics Counter-gravity tectonics Graviquake Elastoquake

H_(2)O_(2) sulfenylates CHE to activate systemic salicylic acid synthesis and ignite systemic acquired resistance: 《Molecular Plant》2024年第12期1794-1796,共3页Kaihuai Li Cheng Li Daowen Wang Fengquan Liu Zheng Qing Fu; National Science Foundation(IOS-2207677 to Z.Q.F.);National Natural Science Foundation of China(32472527 to F.L.).; Reactive oxygen species(ROS),generated within plant cells during metabolic processes or in the plant apoplast when triggered by external microorganisms,comprise a group of unstable molecules that include superoxide an...; 关键词：SYNTHESIS SINGLET UNSTABLE

Osteopontin deficiency promotes cartilaginous endplate degeneration by enhancing the NF-κB signaling to recruit macrophages and activate the NLRP3 inflammasome: 《Bone Research》2024年第4期846-862,共17页Yanqiu Wang Wanqian Zhang Yi Yang Jinghao Qin Ruoyu Wang Shuai Wang Wenjuan Fu Qin Niu Yanxia Wang Changqing Li Hongli Li Yue Zhou Minghan Liu; supported by Chongqing Municipal Natural Science Foundation (CSTB2022NSCQ-MSX1366);National Natural Science Foundation of China (81702182,81874087);Chongqing Outstanding Young Talent Supporting Program (cstc2024ycjhbgzxm0031);the Special Project for Talent Development of Xinqiao Hospital (2022XKRC006)。; Intervertebral disc degeneration(IDD)is a major cause of discogenic pain,and is attributed to the dysfunction of nucleus pulposus,annulus fibrosus,and cartilaginous endplate(CEP).Osteopontin(OPN),a glycoprotein,is hig...; 关键词：NLRP3 DEGENERATION homeostasis

Graphene controlled solid-state growth of oxygen vacancies riched V_(2)O_(5)catalyst to highly activate Fenton-like reaction: 《Chinese Chemical Letters》2024年第12期356-359,共4页Mengxiang Zhu Tao Ding Yunzhang Li Yuanjie Peng Ruiping Liu Quan Zou Leilei Yang Shenglei Sun Pin Zhou Guosheng Shi Dongting Yue; supported by the National Key R&D Program of China(No.2019YFC1803900);the National Natural Science Foundation of China(Nos.U1932123,22073069,21773082,and 42107402);the National Science Fund for Outstanding Young Scholars(No.11722548);the University of Chinese Academy of Sciences(No.WIUCASOD2021014)。; Fenton-like process based on metal oxide presents one of the most hoping strategies to generate reactive oxygen species to treat refractory pollutants.The introduction of oxygen vacancies(OVs)can enhance the catalytic...; 关键词：Oxygen vacancies FENTON-LIKE CATALYSIS V_(2)O_(5) Solid-state synthesis

Engineering the Active Sites of MOF-derived Catalysts:From Oxygen Activation to Activate Metal-Air Batteries被引量：5: 《Chinese Journal of Chemistry》2024年第20期2520-2535,共16页Fanjiao Chen Xueqin Mu Jialing Zhou Shengchen Wang Zhengyang Liu Dingyang Zhou Suli Liu Dingsheng Wang Zhihui Dai; National Natural Science Foundation of China(22234005 and 21974070);the Natural Science Foundation of Jiangsu Province(BK20222015);Young Academic Leaders of the Qing Lan Project of Jiangsu Province(SUJIAOSHIHAN[2022]No.29).; The electrochemical processes of oxygen reduction reaction(ORR)and oxygen evolution reaction(OER)play a crucial role in various energy storage and conversion systems.However,the inherently slow kinetics of reversible ...; 关键词：Metal-organic framework derivatives Electronic structure Active sites Oxygen reduction reaction Oxygen evolution reaction

TaSRT2 recognizes a viral protein to activate host immunity byincreasing histone acetylation: 《Science Bulletin》2024年第20期3206-3211,共6页Kaili Zhong Yaoyao Jiang Haichao Hu Bowen Yuan Mila Wu Aizhu Tu Gecheng Xu Linna Cai Tingting Liu Shiqi Gao Linzhi Li Qiansheng Liao Lidan Guo Ye Xia Peng Liu Ye Cheng Lin Lin Chuanxi Zhang Jianping Chen Jian Yang; supported by the National Key Research and Development Program of China(2023YFD1400300);Zhejiang Provincial Natural Science Foundation of China(LY23C140006);National Natural Science Foundation of China(31901954);Ningbo Natural Science Foundation(2021J126,2023J382);China Agriculture Research System of MOF and MARA(CARS-03)。; Histone acetylation is involved in chromatin structural remodeling and the regulation of gene expression, and it is important for the activation of defense-related gene expression in eukaryotes[1]. The silent informat...; 关键词：IMMUNITY initially ACETYLATION

Deamidation enables pathogenic SMAD6 variants to activate the BMP signaling pathway: 《Science China(Life Sciences)》2024年第9期1915-1927,共13页Ling Li Lei Lu Ziqi Xiao Jingyi Lv Hefeng Huang Bo Wu Tongjin Zhao Chengtao Li Weimin Wang Hongyan Wang; supported by the National Key Research and Development Program of China(2021YFC2701101);the National Natural Science Foundation of China(82150008,81930036);Commission for Science and Technology of Shanghai Municipality(20JC1418500);Open Fund Project of Guangdong Academy of Medical Sciences(YKY-KF202202)。; The BMP signaling pathway plays a crucial role in regulating early embryonic development and tissue homeostasis.SMAD6 encodes a negative regulator of BMP,and rare variants of SMAD6 are recurrently found in individuals...; 关键词：SMAD6 DEAMIDATION BMP signaling pathway GFPT2

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