This work was supported by grants from the Beijing Natural Science Foundation Project(No.7172179);the Public Welfare Industry Scientific Research Fund(No.201502012).
To the Editor:Horseshoes crab is an ancient ocean creature,belonging to Arthropoda.There are three genera,Limulus,Tachypleus,and Carcinoscorpius.[1]Amoebocyte lysate is a lyophilized product extracted from amoebocyte ...
Background:Adiponectin is the most abundant adipokines that plays critical roles in the maintenance of energy homeostasis as well as inflammation regulation. The half-life of adiponectin is very short and the small-mo...
This study was partly supported by grants from the National Natural Science Foundation of China,Shanghai Health System Advanced Suitable Technology Popularization Project,Natural Science Foundation of Shandong Province
Background: Both procalcitonin (PCT) and plasma endotoxin levels cannot be solely used for a definite diagnosis ofbacteremia or sepsis, and there has been few study comparing the values of the two biomarkers for th...
Background A proinflammatory milieu emerging in the lung due to neutrophil accumulation and activation is a key in the pathogenesis of acute lung injury (ALI).15-deoxy-△12,14-prostaglandin J2 (15d-PGJ2),one of th...
This study was supported by a grant from the National Natural Science Foundation of China (No. 30472270).
Background Broad-spectrum antibiotic administration promotes intestinal colonization of exogenous fungal pathogens in healthy animals and has been recognized as one of the risk factors of invasive fungal infection in ...
Background The extracellular release of the danger signal high mobility group box-1 (HMGB1) has been implicated in the pathogenesis and outcomes of sepsis. Understanding the mechanisms responsible for HMGB1 release ...
Background Acute lung injury (ALl) is a serious and common condition for which there are currently no specific strategies for treatment. Recent studies have suggested that bone marrow-derived multipotent mesenchymal...
Background Alpha 2A adrenergic receptor (AR) is a subtype of (]2 AR belonging to G protein-coupled receptors, and exerts a variety of biological effects. Recent studies have demonstrated that the a2A AR activation ...
Background Antithrombin-Ⅲ (AT-Ⅲ), the major inhibitor of thrombin in plasma, also has anti-inflammation property and might have positive effect on sepsis. The present study aimed to investigate the effects of AT-...
This project was supported by the Beijing Natural Science Foundation, China (No. 7032019).
Background Sepsis induced acute lung injury (ALI) as a common syndrome in clinical practice has a high mortality. Recombinant human activated protein C (APC) can significantly reduce the mortality of patients with...