云南高校图书馆联盟文献共享服务平台- EXON

EXON: 作品数：161被引量：414H指数：11; 导出分析报告; 相关领域：医药卫生生物学更多>>; 相关作者：贾天军赵铁军张庶民李萍金鑫燕更多>>; 相关机构：河北北方学院中国药品生物制品检定所青海大学南京军区福州总医院更多>>; 相关期刊：更多>>; 相关基金：国家自然科学基金国家高技术研究发展计划河北省自然科学基金国家科技支撑计划更多>>

Targeted editing of intronic-splicing silencer enhancement of SMN2 Exon 7 inclusion by CRISPR/Case 9: 《BIOCELL》2021年第6期1501-1507,共7页LIUCHENG WU YI WANG LILI DU GUIQING JI RUI ZHOU ZEYI ZHAO JUN CHEN SHUNXING ZHU; Nantong Science and Technology Program,grant number(JC2018090);the Practice Innovation Training Program Projects for the Jiangsu College Students,grant number(201810304028z);the Scientific Innovation Research of College Graduates in Jiangsu Province,grant number(KYCX18-2415)。; Spinal muscular atrophy(SMA)is an autosomal recessive hereditary neuromuscular disease.Exon 7 and 8 of survival of motor neuron 1(SMN1)gene or only exon 7 homology deletion leads to the failure to produce a full-lengt...; 关键词：Spinal muscular atrophy ISS sequence sgRNA HSMN2 CRISPR/Case 9 Inclusion of Exon 7 SMN2 full length

Novel alternative splicing of GABA receptor RDL exon 9 from Laodelphax striatellus modulates agonist potency: 《Insect Science》2021年第3期757-768,共12页Jie Jiang Li-Xin Huang Feng Chen Cheng-Wang Sheng Qiu-Tang Huang Zhao-Jun Han Chun-Qing Zhao; the National Key R&D Program of China(grant No.2017YFD0200900);the Fundamental Research Funds for the Central Universities(grant No.KYZ201710);the National Natural Science Foundation of China(grant No.31871995).; The resistance to dieldrin gene(RDL)encodes the primary subunit of the insect ionotropic y-aminobutyric acid(GABA)receptor(GABAR),which is the target of phenylpyrazole and isoxazoline insecticides.The splice variants ...; 关键词：alternative splicing exon 9 GABA receptor Laodelphax striatellus^RDL

Genome Editing Enables Next-Generation Hybrid Seed Production Technology被引量：25: 《Molecular Plant》2020年第9期1262-1269,共8页Xiantao Qi Congsheng Zhang Jinjie Zhu Changlin Liu Changling Huang Xinhai Li Chuanxiao Xie; supported by grants from Beijing Municipal Science and Technology(Major Program D171100007717001);the National Major Project of Developing New GM Crops(2019ZX08010-003);the Agricultural Science and Technology Innovation Program of Chinese Academy of Agricultural Sciences,the National Science Foundation of China(no.31771808&31361140364);the China National Modern Corn Industry Tech no logy System.; The next-generation hybrid seed technology enables the successful production of sortable hybrid seeds from genic male sterile(GMS)lines and maintainers;however,it requires multiple laborious and complicated steps.Here...; 关键词：CRISPR/Cas9 genic male sterility manipulated maintainer ZmMS26 exon deletion

Structures of the human spliceosomes before and after release of the ligated exon被引量：1: 《Cell Research》2019年第4期274-285,共12页Xiaofeng Zhang Xiechao Zhan Chuangye Yan Wenyu Zhang Dongliang Liu Jianlin Lei Yigong Shi; the National Natural Science Foundation of China(31430020 and 31621092).; Pre-mRNA splicing is executed by the spliceosome,which has eight major functional states each with distinct composition.Five of these eight human spliceosomal complexes,all preceding exon ligation,have been structural...; 关键词：STRUCTURES HUMAN spliceosomes the ligated EXON

SP-C基因exonⅡ结构基因突变与新生儿呼吸窘迫综合征的关系被引量：1: 《实验与检验医学》2018年第5期679-682,共4页牛银萍郭淼付朝阳王喆; 目的探讨表面活性物质蛋白C(SP-C)基因exonⅡ结构基因突变与新生儿呼吸窘迫综合征(NRDS)的关系。方法选取2014年2月至2017年12月在我院治疗的NRDS患儿110例(NRDS组),同时选取新生儿病房非NRDS患儿110例作为对照组,采用PCR及基因分析技...; 关键词：表面活性物质蛋白C exonⅡ结构基因突变新生儿呼吸窘迫综合征

牦牛和普通牛DRB1*Intron1-exon2序列变异分析被引量：3: 《华北农学报》2016年第3期72-79,共8页田知利陈杰胡江罗玉柱刘秀李少斌郭淑珍牟永娟; 甘肃省杰出青年科学基金项目(1210RJDA008);甘肃省农业生物技术研究与应用开发项目(GNSW-2013-9); 为揭示牦牛抗逆性及抗病育种积累更多的分子遗传学资料,通过检测DRB1基因在牦牛和普通牛群体中的变异,分析该基因检测区域遗传参数。以甘南牦牛、青海牦牛、天祝白牦牛、大通牦牛和普通牛为研究对象。应用PCR-SSCP方法检测BoLA-DRB1基因...; 关键词：牦牛普通牛 DRB1基因 Intron l EXON 2 多态性

Molecular characterization of DnaJ 5 homologs in silkworm Bombyx mori and its expression during egg diapause被引量：3: 《Insect Science》2014年第6期677-686,共10页Sasibhushan Sirigineedi Esvaran Vijayagowri Geetha N. Murthy Guruprasada Rao Kangayam M. Ponnuvel; A comparison of the cDNA sequences （1 056 bp） of Bombyx mori DnaJ 5 homolog with B. mori genome revealed that unlike in other Hsps, it has an intron of 234 bp. The DnaJ 5 homolog contains 351 amino acids, of which 7...; 关键词：Bombyx mori DIAPAUSE DNAJ EXON Hsp40 INTRON

MHC Class I Exon 4 in the Multiocellated Racerunners(Eremias multiocellata): Polymorphism, Duplication and Selection: 《Asian Herpetological Research》2014年第2期91-103,共13页Xiuyun YUAN Xiaomao ZENG Xianguang GUO; supported by the Science and Technology Project for Outstanding Youths in Life Science (KSCX2-EW-Q-6) from the Chinese Academy of Sciences;National Natural Science Foundation of China (31272281); The major histocompatibility complex （MHC） is a dynamic genetic region with an essential role in the adaptive immunity of jawed vertebrates. The MHC polymorphism is affected by many processes such as birth-and- deat...; 关键词：MHC class I Eremias multiocellata trans-species polymorphism balancing selection purifying selection birth-and-death evolution

Correlation between serum CEA levels and EGFR mutations in Chinese nonsmokers with lung adenocarcinoma被引量：11: 《Acta Pharmacologica Sinica》2014年第3期373-380,共8页Bo JIN Yu DONG Hui-min WANG Jin-su HUANG Bao-hui HAN; Aim： To evaluate the relationship between epidermal growth factor receptor （EGFR） mutations and serum carcinoembryonic antigen （CEA） levels in Chinese nonsmokers with pulmonary adenocarcinoma. Methods： We sequen...; 关键词：lung cancer ADENOCARCINOMA BIOMARKER carcinoembryonic antigen EGFR mutation exon 19 deletion nonsmoker

Intragenic DNA methylation modulates alternative splicing by recruiting MeCP2 to promote exon recognition被引量：19: 《Cell Research》2013年第11期1256-1269,共14页Alika K Maunake Iouri Chepelev Kairong Cui Keji Zhao; Although the function of DNA methylation in gene promoter regions is well established in transcriptional repression, the function of the evolutionarily conserved widespread distribution of DNA methylation in gene body...; 关键词：MECP2 splicing chromatin intragenic DNA methylation EPIGENOMICS histone acetylation

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