GUANIDINES

作品数：11被引量：27H指数：2
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相关领域：理学更多>>
相关作者：陈晓玲黄善生李文斌周爱民王新良更多>>
相关机构：河北医科大学上海大学更多>>
相关期刊：《Organic Chemistry Frontiers》《Acta Pharmacologica Sinica》《World Journal of Gastroenterology》《Chinese Medical Journal》更多>>
相关基金：国家自然科学基金河南省自然科学基金更多>>
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N<sup>ω</sup>-Nitro-N<sup>ω’</sup>-Substituted Guanidines: A Simple Class of Nitric Oxide Synthase Inhibitors
《Modern Research in Inflammation》2014年第2期48-58,共11页Christophe D. Guillon David D. Wisnoski Jaya Saxena Ned D. Heindel Diane E. Heck Donald J. Wolff Jeffrey D. Laskin 
A series of Nω-nitro-Nω’-substituted guanidines has been prepared as potential inhibitors of the human Nitric Oxide Synthase (NOS) isoforms. The reported utility of amino-guanidine and nitroarginine in iNOS inhibit...
关键词：Nitro-Guanidines Nitric Oxide SYNTHASE (NOS) ISOFORMS Selective Inhibitors 
Effects of aminoguanidine on nitric oxide production induced by inflammatory cytokines and endotoxin in cultured rat hepatocytes被引量：20
《World Journal of Gastroenterology》2001年第3期331-334,共4页Guo Liang Zhang Ye Hong Wang Hui Ling Teng Zhi Bin Lin Department of Pharmacology,School of Basic Medical Sciences,Beijing University,Beijiog 100083,ChinaDr.Guo Liang Zhang graduated from Xinxiang Medical College in 1982,got Ph.D.at Nagoya City University Medical School,Japan in 1994,finished postdoctoral research at Beijing Medical Univcrsity in 1996,now an associate professor of pharmacology,specialized in hepatic pharmacology,having 15 papers published. 
Project supported by the National Natural Science Foundation of China,No.39770861.and JANSSEN Science Research Foundation.
AIM: To study the effects of aminoguanidine (AG) and two L-arginine analogues N(omega)-nitro-L-arginine methyl ester (L-NAME) and N(omega)-nitro-L-arginine (L-NNA) on nitric oxide (NO) production induced by cytokines ...
关键词：Animals Antineoplastic Agents Cells  Cultured Comparative Study Cyclic GMP Cytokines DACTINOMYCIN Dexamethasone Enzyme Inhibitors Glucocorticoids GUANIDINES Hepatocytes Interferon Type II INTERLEUKIN-1 LIPOPOLYSACCHARIDES Male NG-Nitroarginine Methyl Ester Nitric Oxide Nitric Oxide Synthase inhibitors Nitroarginine Protein Synthesis Inhibitors RATS Rats  Wistar Research Support  Non-U.S. Gov't Tumor Necrosis Factor-alpha 
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