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作品数：131被引量：355H指数：10
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Identification and analysis of immunological activity of two isoforms of tropomyosin in Alectryonella plicatula
《Food Science and Human Wellness》2024年第6期3697-3707,共11页Shiqiang Yang Yexin Chen Fei Huan Xinrong He Xiao Yun Hong Liu Guixia Chen Guangming Liu 
supported by the National Natural Scientific Foundation of China(32072336,32472449).
Oyster,as a common aquatic food,play an important role in shellfish allergy.In this study,2 tropomyosin(TM)isoforms TM-αand TM-β(TM-α/-β)in Alectryonella plicatula were identified.The sequences of 852 bp encoding ...
关键词：Alectryonella plicatula ALLERGEN Immunological activity ISOFORMS TROPOMYOSIN 
Direct RNA sequencing in plants:Practical applications and future perspectives被引量：1
《Plant Communications》2024年第11期54-71,共18页Xi-Tong Zhu Pablo Sanz-Jimenez Xiao-Tong Ning Muhammad Tahir ul Qamar Ling-Ling Chen 
Guangxi Natural Science Foundation(2024GXNSFGA010003);National Natural Science Foundation of China(32270712 and 31871269);Guangxi Science and Technology Major Program(AA23062085).
The transcriptome serves as a bridge that links genomic variation to phenotypic diversity.A vast number of studies using next-generation RNA sequencing(RNA-seq)over the last 2 decades have emphasized the essential rol...
关键词：direct RNA sequencing novel isoforms fusion transcripts poly(A)tail RNA modifications 
Suppression of mature TAU isoforms prevents Alzheimer's disease-like amyloid-beta oligomer-induced spine loss in rodent neurons被引量：1
《Neural Regeneration Research》2024年第8期1655-1657,共3页Sarah Buchholz Hans Zempel 
supported by the Deutsche Forschungsgemeinschaft and the Else-Kroner-Fresenius-Stiftung(to HZ)。
Introduction:TAU isoforms as disease mediators:The microtubule-associated protein TAU is predominantly present in the axons of neurons under physiological conditions.In Alzheimer’s disease(AD)and related tauopathies,...
关键词：Alzheimer Zimmer TAU 
RNAirport:a deep neural network-based database characterizing representative gene models inplants被引量：1
《Journal of Genetics and Genomics》2024年第6期652-664,共13页Sitao Zhu Shu Yuan Ruixia Niu Yulu Zhou Zhao Wang Guoyong Xu 
supported by grants from the National Key R&D Program of China(2023ZD04073);the Major Project of Hubei Hongshan Laboratory(2022hszd016);the Key Research and Development Program of Hubei Province(2022BFE003);the National Natural Science Foundation of China(32070284)to G.Xu.
A 5'-leader,known initially as the 5'-untranslated region,contains multiple isoforms due to alternative splicing(aS)and alternative transcription start site(aTSS).Therefore,a representative 5'-leader is demanded to ex...
关键词：5'-leader Transcript isoforms RNA regulatory elements UORF Deep learning Synthetic biology Translational control 
Poly(A)-specific RNase(PARN)generates and regulates miR-125a-5p 3’-isoforms,displaying an altered expression in breast cancer被引量：2
《Signal Transduction and Targeted Therapy》2024年第5期1805-1807,共3页Luisa Tomasello Shoshanah M.Holub Giovanni Nigita Rosario Distefano Carlo M.Croce 
The authors thank the Genomics Shared Resource at The Ohio State University Comprehensive Cancer Center(OSU CCC),Columbus,OH.This work was supported by the NCI(NIH)grant R35CA197706 to C.M.Croce.
Dear Editor,MicroRNAs(miRNAs)are small non-coding RNAs crucial for post-transcriptional gene regulation,processed from primary miRNA transcripts by Drosha and Dicer.1 Latest advancements in Next Generation Sequencing ...
关键词：BREAST cancer advancement 
Thirteen years to get from b to a:one of the neglected isoforms of IL-37 enters the stage
《Cellular & Molecular Immunology》2024年第2期201-202,共2页Steven X.Cho Ina Rudloff Andrew M.Ellisdon Claudia A.Nold-Petry Marcel F.Nold 
Interleukin(IL)-37 is one of the few anti-inflammatory members of the predominantly pro-inflammatory IL-1 cytokine family.IL-37 possesses alarmin-like properties[1]and exerts its activities via intracellular[2]as well...
关键词：INTERLEUKIN NEGLECTED CYTOKINE 
Tocotrienol isoforms:The molecular mechanisms underlying their effects in cancer therapy and their implementation in clinical trials
《Journal of Integrative Medicine》2024年第1期1-11,共11页Maria Younes Ghady Loubnane Christopher Sleiman Sandra Rizk 
Tocotrienols are found in a variety of natural sources,like rice bran,annatto seeds and palm oil,and have been shown to have several health-promoting properties,particularly against chronic diseases such as cancer.The...
关键词：Vitamin E Tocotrienols Cancer Molecular mechanism Clinical trials 
Impact of apolipoprotein E isoforms on sporadic Alzheimer's disease:beyond the role of amyloid beta被引量：4
《Neural Regeneration Research》2024年第1期80-83,共4页Madia Lozupone Francesco Panza 
The impact of apolipoprotein E(ApoE)isoforms on sporadic Alzheimer's disease has long been studied;however,the influences of apolipoprotein E gene(APOE)on healthy and pathological human brains are not fully understood...
关键词：Alzheimer's disease AMYLOID-BETA apolipoprotein E DEMENTIA glymphatic transport LIPIDS neuropsychiatric symptoms neurovascular unit tau protein 
The nuclear cytokine IL-37a controls lethal cytokine storms primarily via IL-1R8-independent transcriptional upregulation of PPARγ被引量：2
《Cellular & Molecular Immunology》2023年第12期1428-1444,共17页Rongfei Wei Xiao Han Mengyuan Li Yuan Ji Lianfeng Zhang Maria-Ioanna Christodoulou Najwa Jameel Hameed Aga Caiyan Zhang Ran Gao Jiangning Liu Jinrong Fu Guoping Lu Xiaojun Xiao Xiaoyu Liu Ping-Chang Yang Iain B.McInnes Ying Sun Peisong Gao Chuan Qin Shau-Ku Huang Yufeng Zhou Damo Xu 
support from Versus Arthritis UK(21327 to D.X.);the National Key R&D Program of China(2021YFC2701800 and 2021YFC2701802 to Y.Z.),the National Natural Science Foundation of China(82241038,81974248 to Y.Z.and 81900751 to X.H.);the International Joint Laboratory Program of National Children’s Medical Center(EK1125180109 to Y.Z.);the Program for Outstanding Medical Academic Leader(2019LJ19 to Y.Z.);the Shanghai Rising-Star Program(22QA1401500 to X.H.);the Shanghai Committee of Science and Technology(21140902400 to Y.Z.,23ZR1407600,21ZR1410000 to F.J.and 20ZR1408300 to X.H.);the Shenzhen Science and Technology Peacock Team Project(KQTD20170331145453160);the National Health Research Institutes,Taiwan,China(EM-109-PP-10).
Cytokine storms are crucial in the development of various inflammatory diseases,including sepsis and autoimmune disorders.The immunosuppressive cytokine INTERLEUKIN(IL)-37 consists of five isoforms(IL-37a-e).We identi...
关键词：IL-37 isoforms IL-37a Nuclear cytokine receptor-independent 
Prognostic value of AKT isoforms in non-small cell lung adenocarcinoma
《The Journal of Biomedical Research》2023年第3期225-228,共4页Sahil Khurana Ajay Pal Singh Ashok Kumar Rajeev Nema 
Dear Editor,Lung cancer is one of the most prevalent cancers in the world and has a high mortality rate.Lung cancer patients often have a poor prognosis,with a five-year survival rate of only about 16%.The Internation...
关键词：LUNG LUNG CANCER 
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