ARTESUNATE

作品数：73被引量：225H指数：8
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相关作者：姚丽谢红靳秋月陈立军王静更多>>
相关机构：武警医学院太原市第三人民医院山西医科大学山西省肿瘤医院更多>>
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NUMB endocytic adaptor protein(NUMB)mediates the anti-hepatic fibrosis effect of artesunate(ART)by inducing senescence in hepatic stellate cells(HSCs)
《Chinese Journal of Natural Medicines》2025年第3期322-333,共12页Yangling Qiu Yujia Li Mengran Li Yingqian Wang Min Shen Jiangjuan Shao Feng Zhang Xuefen Xu Feixia Wang Zili Zhang Shizhong Zheng 
supported by the National Natural Science Foundation of China(Nos.82474164,82374124,82073914,82173874,82274185,82305046 and 82304902);the Natural Science Foundation of Jiangsu Province(Nos.BK20230458 and BK20220467);the General Project of the Natural Science Research of Jiangsu Higher Education Institutions(No.23KJB310017);Young Elite Scientists Sponsorship Program by CACM(No.2022-QNRC2-B15).
Developing and identifying effective medications and targets for treating hepatic fibrosis is an urgent priority.Our previous research demonstrated the efficacy of artesunate(ART)in alleviating liver fibrosis by elimi...
关键词：Hepatic stellate cells NUMB endocytic adaptor protein SENESCENCE ARTESUNATE UBIQUITYLATION Liver fibrosis 
A self-assembled nanomicelle-based "one stone for two birds" strategy for precision therapy of hepatic ischemia-reperfusion injury
《Nano Research》2025年第2期627-640,共14页Mengyuan Yu Jiongjie Yu Yujie Zhou Zhi Liang Hong Tang Changbiao Li Qingyang Que Hangxiang Wang Haiyang Xie Xiao Xu 
This research gained support from the National Key Research and Development Program of China(No.2021YFA1100500);the Major Research Plan of the National Natural Science Foundation of China(No.92159202);the National Natural Science Foundation of China(Nos.32171368 and 81930016);State Key Laboratory for Diagnosis and Treatment of Infectious Diseases(No.zz202310);the Non profit Central Research Institute Fund of Chinese Academy of Medical Sciences(No.2023-PT320-02);the International Science and Technology Cooperation Project of Zhejiang province.
Hepatic ischemia-reperfusion injury(IRI)is an intricate and inevitable physiological event occurred in the liver transplantation(LT)and it is of paramount importance to devise novel and efficient methods to ameliorate...
关键词：carvacrol(CAR) artesunate(ART) nanoparticles ischemia-reperfusion injury(IRI) ferroptosis 
Artesunate Induces Ferroptosis in Hepatic Stellate Cells and Alleviates Liver Fibrosis via the ROCK1/ATF3 Axis
《Journal of Clinical and Translational Hepatology》2024年第1期36-51,共16页Yingqian Wang Yujia Li Yangling Qiu Min Shen Ling Wang Jiangjuan Shao Feng Zhang Xuefen Xu Zili Zhang Mei Guo Shizhong Zheng 
supported by the National Natural Science Foundation of China(No.82000572,82073914,82173874,82274185);the Natural Science Foundation of Jiangsu Province(No.BK20220467,BK20200840);the Major Project of the Natural Science Research of Jiangsu Higher Education Institutions(No.22KJB310013,19KJA310005);the Joint Project of Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica and Yangtze River Pharmaceutical(No.JKLPSE202005);the Natural Science Foundation of Nanjing University of Chinese Medicine(No.NZY82000572);Nanjing Pharmaceutical Association-Changzhou Fourth Pharmaceutical Hospital Pharmaceutical Research Fund(NO.2021YX030);Postgraduate Research&Practice Innovation Program of Jiangsu Province(No.SJCX22_0792).
Background and Aims:Development of fibrosis in chronic liver disease requires activation of hepatic stellate cells(HSCs)and leads to a poor outcome.Artesunate(Art)is an ester derivative of artemisinin that can induce ...
关键词：Ferroptosis Liver fibrosis Antioxidant system ATF3 ROCK1 
Artesunate对克罗恩病样结肠炎的保护性作用及机制
《齐齐哈尔医学院学报》2019年第8期925-928,共4页席进 朱玉可 吴华涛 周杰 王研 葛思堂 左芦根 
蚌埠医学院自然科学重点项目(BYKY1836ZD)
目的探讨青蒿琥酯(Artesunate)对TNBS结肠炎小鼠的治疗作用及机制。方法采用6～8周龄Balb/c小鼠,建立TNBS模型后将16只小鼠随机分为Artesunate组及Model组两组,每组8只。Artesunate组小鼠每日腹腔注射Artesunate(150 mg/kg/d),Model组...
关键词：青蒿琥酯 克罗恩病 黏膜免疫 肠屏障功能 肠炎 
Anti-inflammatory and antipyretic activities of artesunate in experimental animals
《Journal of Coastal Life Medicine》2016年第9期737-741,共5页Ette Ettebong Emmanuel Etuk Imaobong Sunday 
Supported by Education Trust Fund of the University of Uyo(Grant No.ETF 057).
Objective:To evaluate the anti-inflammatory and antipyretic potentials of artesunate in albino mice and Wistar rats respectively.Methods:For the anti-inflammatory activity,artesunate(5 mg/kg)was administered orally ag...
关键词：ARTESUNATE ANTI-INFLAMMATORY ANTIPYRETIC IBUPROFEN 
Antimalarial drug artesunate affords protection against carrageenan induced acute inflammation in rat
《BIOCELL》2014年第1期1-5,共5页Vijay L.KUMAR B.GURUPRASAD Priyanka CHAUDHARY 
research grant(A-059)from All India Institute of Medical Sciences,New Delhi.Artesunate and diclofenac were kind gifts from Arbro Pharmaceuticals Ltd.,New Delhi.
Artesunate, an antimalarial drug, has been shown to inhibit the release of inflammatory mediators in various disease conditions. The present study was carried out to evaluate the anti-edematogenic effect of arte- suna...
关键词：ARTESUNATE EDEMA MYELOPEROXIDASE TNF-α PGE_(2) 
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