EPITOPES

作品数:96被引量:141H指数:7
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相关领域:医药卫生更多>>
相关作者:郭礼和费俭夏国宏邢力叶欣更多>>
相关机构:中国科学院上海生命科学研究院郑州大学南昌大学广州血液中心更多>>
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相关基金:国家自然科学基金World Health Organization国家重点基础研究发展计划中国博士后科学基金更多>>
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  • 期刊=World Journal of Gastroenterologyx
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Quasispecies dynamics in main core epitopes of hepatitis B virus by ultra-deep-pyrosequencing被引量:5
《World Journal of Gastroenterology》2012年第42期6096-6105,共10页Maria Homs Maria Buti David Tabernero Josep Quer Alex Sanchez Noelia Corral Rafael Esteban Francisco Rodriguez-Frias 
Supported by A Grant from the Spanish Ministry of Health and Consumer Affairs,No. FIS PS09/00899 and SAF 2009-10403;CIBERehd Funded by Instituto CarlosⅢ,Ministry of Health and Consumer Affairs
AIM:To investigate the variability of the main immunodominant motifs of hepatitis B virus(HBV) core gene by ultra-deep-pyrosequencing(UDPS).METHODS:Four samples(2 genotype A and 2 genotype D) from 4 treatment-na ve pa...
关键词:Hepatitis B virus Ultra-deep-pyrosequencing EPITOPES Quasispecies Linkage analysis 
Natural epitope variants of the hepatitis C virus impair cytotoxic T lymphocyte activity被引量:1
《World Journal of Gastroenterology》2010年第16期1953-1969,共17页Shuping Wang Rico Buchli Jennifer Schiller Jianen Gao Rodney S VanGundy William H Hildebrand David D Eckels 
Supported by The National Institutes of Health, No. NIH-DK-57732
AIM:To understand how interactions between hepatitis C virus(HCV) and the host's immune system might lead to viral persistence or effective elimination of HCV.METHODS:Nucleotides 3519-3935 of the non-structural 3(NS3)...
关键词:EPITOPES Human T Cells CYTOTOXIC ANERGY VIRAL 
Catalytic domain of PDC-E2 contains epitopes recognized by antimitochondrial antibodies in primary biliary cirrhosis被引量:13
《World Journal of Gastroenterology》2010年第8期973-981,共9页Sandra Braun Christoph Berg Sandra Buck Michael Gregor Reinhild Klein 
AIM:To search for further immunodominant peptides of the pyruvate dehydrogenase complex E2-component (PDC-E2) recognized by antimitochondrial antibodies (AMA) in primary biliary cirrhosis (PBC). METHODS:Sera from 95 p...
关键词:Anti-M2 Epitope mapping E2-subunit Pyruvate dehydrogenase complex Inner lipoyl domain Active site Catalytic domain Primary biliary cirrhosis 
Expression and immunoreactivity of HCV/HBV epitopes被引量:1
《World Journal of Gastroenterology》2005年第41期6440-6444,共5页Xin-Yu Xiong Xiao Liu Yuan-Ding Chen 
Supported by the Yunnan Province Natural Science Foundation,No. 2003C0076M
AIM: To develop the epitope-based vaccines to prevent Hepatitis C virus (HCV)/Hepatitis B virus (HBV) infections. METHODS: The HCV core epitopes C1 STNPKPQRKTKRNTNRRPQD (residuals aa2-21) and C2 VKFPGGGQIVGGVY...
关键词:HCV HBV Epitope-based vaccine RECOMBINANT Xmmunoreactivity 
Phage displaying peptides mimic schistosoma antigenic epitopes selected by rat natural antibodies and protective immunity induced by their immunization in mice
《World Journal of Gastroenterology》2005年第19期2960-2966,共7页MinWang Xin-YuanYi Xian-PingLi Dong-MingZhou McReynoldsLarry Xian-FangZeng 
Supported by the WHO/TDR, No. 980255 and the Science Commission of Hunan Province, No. 00jzy2115
AIM: To obtain the short peptides mimic antigenic epitopes selected by rat natural antibodies to schistosomes, and to explore their immunoprotection against schistosomiasis in mice.METHODS: Adults worm antigens (AWA) ...
关键词:SCHISTOSOME Phage peptide library EPITOPE Mimic peptide Protective immunity Vaccine 
Construction of exogenous multiple epitopes of helper T lymphocytes and DNA immunization of its chimeric plasmid with HBV pre-S2/S gene被引量:2
《World Journal of Gastroenterology》2004年第20期2979-2983,共5页Wen-JunGao Xiao-MouPeng Dong-YingXie Qi-FengXie Zhi-LiangGao Ji-LuYao Wen-JunGao 
Supported by the National Natural Science Foundation of China,NO.39970677 and the Science Foundation of Guangdong Province,NO.99M04801G
AIM: To design and construct an exogenous multiple epitope of helper T lymphocytes (HTL), and to evaluate its effect on anti-HBs response through DNA immunization. METHODS: Artificial HTL epitope, PADRE and four other...
关键词:外生性 多发性 抗原 辅助机车T 淋巴细胞 DNA 免疫学 质粒 HBV pre-S2/S基因 HTL 基因表达 
Construction and characterization of an experimental ISCOMS-based hepatitis B polypeptide vaccine被引量:11
《World Journal of Gastroenterology》2002年第2期294-297,共4页Xiao-Ju Guan Shanghai Institute of Materia Medica,Chinese Academy of Sciences,Shanghai 200031,China,previously worked as a postdoc in Institute of Immunology,Third Military Medical University,Chongqing 400038,China Xiao-Jun Guan,Department of Science & Research,Second Military Medical University,Shanghai 200433,China Yu-Zhang Wu Zheng-Cai Jia Tong-Dong Shi Yan Tan,Institute of Immunology,Third Military Medical University,Chongqing 400038,China 
the National Natural Science Foundation of China,No.39789010
AIM: To characterize the biochemical and immunological properties of an experimental ISCOMS vaccine prepared from a novel therapeutic polypeptide based on T cell epitopes of HBsAg, and a heptatis B-ISCOMS was prepared...
关键词:Hepatitis B Vaccines ISCOMS Animals Enzyme-Linked Immunosorbent Assay EPITOPES Female Hepatitis B Surface Antigens Humans Interferon Type II MICE Mice  Inbred BALB C Peptides Research Support  Non-U.S. Gov't T-Lymphocytes  Cytotoxic 
Identification of the epitopes on HCV core protein recognized by HLA-A2 restricted cytotoxic T lymphocytes被引量:11
《World Journal of Gastroenterology》2001年第4期583-586,共4页Hong-Chao Zhou De-Zhong Xu Xue-Ping Wang Jing-Xia Zhang Ying-Huang Yong-Ping Yan Yong Zhu Bo-Quan Jin Department of Epidemiology,the Fourth Military Medical University,Xi’an 710033,Shaanxi Province,ChinaDepartment of Immunology,the Fourth Military Medical University,Xi’an 710033,Shaanxi Province,China 
the National Nature Science Foundation of China,No.39800121
AIM: To identify hepatitis C virus(HCV) core protein epitopes recognized by HLA-A2 restricted cytotoxic T lymphocyte (CTL). METHODS: Utilizing the method of computer prediction followed by a 4h(51)Cr release assay con...
关键词:Amino Acid Sequence Antibodies  Viral B-LYMPHOCYTES Cell Line Epitope Mapping HLA-A2 Antigen HEPACIVIRUS Hepatitis C Humans Peptide Fragments Predictive Value of Tests Research Support  Non-U.S. Gov't T-Lymphocytes  Cytotoxic Viral Core Proteins 
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