ANERGY

作品数：9被引量：17H指数：2
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mIgM-mediated splenic marginal zone B cells targeting of folic acid for immunological evasion被引量：2
《Acta Pharmaceutica Sinica B》2024年第2期808-820,共13页Huan Wang Zhuxuan Jiang Zhiwei Guo Gan Luo Tianhao Ding Changyou Zhan 
supported by the National Natural Science Foundation of China(82125035,81973245 and 82373817,China);Shanghai Education Commission Major Project(2021-01-07-00-07-E00081,China)。
Folic acid is a fully oxidized synthetic folate with high bioavailability and stability which has been extensively prescribed to prevent congenital disabilities.Here we revealed the immunosuppressive effect of folic a...
关键词：Membrane-bound IgM Anti-drugantibodies Bcell anergy Folic acid Marginal zoneBcells Bcell receptor BIOLOGICS TARGETING 
Dysregulation of Circular Antigen-Specific T Cells Anergy in Autoimmune Vitiligo
《Journal of Cosmetics, Dermatological Sciences and Applications》2018年第3期133-139,共7页Atsushi Tanemura Lingli Yang Ichiro Katayama 
Background: Vitiligo is an autoimmune disorder related to melanocyte loss;however, the exact interplay between antigen-specific autoimmunity and local oxidative stress remains unclear. Recently, the migration ability ...
关键词：AUTOIMMUNE VITILIGO T CELL ANERGY Functional REGULATORY T CELL 
Novel exosome-targeted T-cell-based vaccine counteracts T-cell anergy and converts CTL exhaustion in chronic infection via CD40L signaling through the mTORC1 pathway被引量：5
《Cellular & Molecular Immunology》2017年第6期529-545,共17页Rong Wang Aizhang Xu Xueying Zhang Jie Wu Andrew Freywald Jianqing Xu Jim Xiang 
CD8＋ cytotoxic T lymphocyte （CTL） exhaustion is a chief issue for ineffective virus elimination in chronic infectious diseases. We generated novel ovalbumin （OVA）-specific OVA-Texo and HIV-specific Gag-Texo vacci...
关键词：anti-CD40 Ab CD40L signaling chronic infection CTL exhaustion HIV Gag mTORC1 pathway T-cellanergy therapeutic T-cell vaccine 
Adaptive immune response during hepatitis C virus infection被引量：7
《World Journal of Gastroenterology》2014年第13期3418-3430,共13页Juan Ramon Larrubia Elia Moreno-Cubero Megha Uttam Lokhande Silvia Garcia-Garzon Alicia Lazaro Joaquin Miquel Cristian Perna Eduardo Sanz-de-Villalobos 
Grants from"Instituto de Salud Carlos Ⅲ",Spain and"European Regional Development Fund(ERDF),a way of making Europe",E.U.,No.PI12/00130;"Fundacion de In-vestigacion Medica Mutua Madrilena",Spain,No.8922/2011;Lokhande MU was funded by a research grant from"Asoci-acion de Hepatologia Translacional"No.AHT-2010/01,Spain
Hepatitis C virus(HCV)infection affects about 170 million people worldwide and it is a major cause of liver cirrhosis and hepatocellular carcinoma.HCV is a hepatotropic non-cytopathic virus able to persist in a great ...
关键词：Hepatitis C  Adaptive immune response  Hepatitis C virus-specific cytotoxic T cells  Hepatitis C virus-specific T helper cells  T regs  Hepatitis C virus escape mutations  Anergy  Apoptosis  Chemotaxis 
Clopidogrel Anergy and Monitored被引量：1
《血栓与止血学》2014年第1期1-1,共1页刘泽霖 
Clopidogrel Anergy2003 Germany Müller et at 105 patients with stable coronary artery disease using clopidogrel for PCI,about5%of patients showed no response to the drug,which is defined as platelets in the 20μmol/L ...
关键词：CLOPIDOGREL ANERGY Monitored 
New era in cancer immunotherapy: Twenty years to the discovery of monoclonal antibodies harnessing the immune system to eradicate tumors
《Advances in Bioscience and Biotechnology》2013年第4期34-37,共4页Britta Hardy Annat Raiter 
The better understanding of the mechanism in which the immune system responds to the developing cancer provided the outcome in a new era in cancer immunotherapy. The tumor suppressive effect on the immune system is ca...
关键词：Cancer IMMUNOTHERAPY MONOCLONAL ANTIBODIES ANERGY T Cell RECEPTORS 
Immune reaction characteristics and the mechanism of anergy induced by recombinant enterotoxin a of Staphylococcus aureus
《Journal of Biomedical Science and Engineering》2010年第6期543-549,共7页Shang Wu Renli Zhang Dana Huang Yijie Geng Shitong Gao Xiaoheng Li Zhangli Hu 
To study immune reactions and the mechanism of anergy induced by recombinant enterotoxin A (rSEA) of Staphylococcus aureus. The gene encoding SEA was cloned from standard strain of S. aureus and high efficiently expre...
关键词：STAPHYLOCOCCUS AUREUS ENTEROTOXIN A Im- MUNE Respose 
Natural epitope variants of the hepatitis C virus impair cytotoxic T lymphocyte activity被引量：1
《World Journal of Gastroenterology》2010年第16期1953-1969,共17页Shuping Wang Rico Buchli Jennifer Schiller Jianen Gao Rodney S VanGundy William H Hildebrand David D Eckels 
Supported by The National Institutes of Health, No. NIH-DK-57732
AIM:To understand how interactions between hepatitis C virus(HCV) and the host's immune system might lead to viral persistence or effective elimination of HCV.METHODS:Nucleotides 3519-3935 of the non-structural 3(NS3)...
关键词：EPITOPES Human T Cells CYTOTOXIC ANERGY VIRAL 
Frequency and Absolute Number of FoxP3^+ Regulatory T Cells Correlate with Disease Progression of Chronic HIV-1 Infection被引量：1
《Virologica Sinica》2007年第6期501-508,共8页Jun-liang FU Fu-biao KANG Yan-mei JIAO Shao-jun XING Bao-yun FU Chun-bao ZHOU Xi-cheng WANG Hao WU Fu-Sheng WANG 
The National Outstanding Youth Foundation of China (30525042);National 973 project of China (2006CB504201,2006CB504205)
CD4^＋CD25^＋ Regulatory T cells （Treg） have been found to down-regulate immune activation in HIV-1 infection. However, whether the depletion of Treg benefits to the disease status of HIV infection remains undefined...
关键词：T-LYMPHOCYTES HIV Infections Tolerance/Suppression/Anergy Proliferation 
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