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EPITOPES: 作品数：96被引量：141H指数：7; 导出分析报告; 相关领域：医药卫生更多>>; 相关作者：郭礼和费俭夏国宏邢力叶欣更多>>; 相关机构：中国科学院上海生命科学研究院郑州大学南昌大学广州血液中心更多>>; 相关期刊：更多>>; 相关基金：国家自然科学基金World Health Organization国家重点基础研究发展计划中国博士后科学基金更多>>

Structural insights into the distinct protective mechanisms of human antibodies targeting ZIKV NS1: 《hLife》2024年第10期527-541,共15页Qi Pan Xiaomin Xing Jianhai Yu Qiang Chen Haizhan Jiao Wanqin Zhang Yingfen Wen Ming Gao Wei Zhao Lei Yu Hongli Hu; supported by grants from the National Natural Science Foundation of China(81971924 to L.Y.and 32370146 to W.Z.);Guangzhou Municipal Science and Technology Bureau(2023A03J0791 to L.Y.);Guangdong Science and Technology Program(2021B1212030014 to W.Z.);Guangdong Basic and Applied Basic Research Fund Enterprise Joint Fund(2021A1515220017 to W.Z.);Medical Scientific Research Foundation of Guangdong Province(B2022112 to J.Y.),Shenzhen Science and Technology Innovation Committee(JCYJ20210324131802008 to H.H.);Ganghong Young Scholar Development Fund(to H.H.);the Shenzhen-Hong Kong Cooperation Zone for Technology and Innovation(HZQB-KCZYB-2020056 to H.H.);the Kobilka Institute of Innovative Drug Discovery and Presidential Fellowship and University Development Fund at the Chinese University of Hong Kong,Shenzhen(to H.H.,H.J.,and Q.C.);Presidential Fellowship at the Chinese University of Hong Kong,Shenzhen(to Q.P.and W.Z.)。; Antibodies targeting non-structural protein 1(NS1)confer protection against Zika virus(ZIKV).Although monoclonal an-tibodies(MAbs)3G2 and 4B8 are more potent than MAb 4F10 in suppressing ZIKV infection in neonatal mic...; 关键词：Zika virus(ZIKV) non-structural protein 1(NS1) monoclonal antibodies(MAbs) EPITOPES

Neutralization of SARS-CoV-2 infection by antibodies targeting diverse epitopes: 《Genes & Diseases》2024年第4期134-137,共4页Shusheng Wang Yunji Liao Kaiyong Yang Hang Ma Zhangyi Song Haiqiu Huang Li Zhang Ailing Wang Lei Han Jiawei Zhang Hui Chen Haiyang Yin Yantin Bian Hua Jiang Xiaodong Xiao Yueqing Xie Yunsheng Yuan Jianwei Zhu; the National Natural Science Foundation of China(No.81773621,82073751 to JZ);the National Science and Technology Major Project"Key New Drug Creation and Manufacturing Program"of China(No.2019ZX09732001-019 to JZ);the Key R&D Supporting Program(Special support for developing medicine for infectious diseases)from the Administration of Chinese and Singapore Tianjin Eco-city to Jecho Biopharmaceuticals Ltd.Co.,Zhejiang University special CoVID-19 grant 2020XGZX099;Shanghai Jiao Tong University"Crossing Medical and Engineering"grant 20X190020003 to JZ.; The CoVID-19 pandemic that started in late 2019 is sweeping through the world,posing historic challenges to global health,and disrupting social and economic lives.Previous and recent studies indicate that monoclonal a...; 关键词：ANTIBODIES inhibited MONOCLONAL

Nonconserved epitopes dominate reverse preexisting T cell immunity in COVID-19 convalescents: 《Signal Transduction and Targeted Therapy》2024年第7期2984-2998,共15页Xin Wang Jie Zhang Maoshun Liu Yuanyuan Guo Peipei Guo Xiaonan Yang Bingli Shang Min Li Jinmin Tian Ting Zhang Xi Wang Ronghua Jin Jikun Zhou George F.Gao Jun Liu; supported by the National Key Research and Development Program of China(2022YFC2604100 to J.L.,and 2023YFC2306003 to X.W.);the National Natural Science Foundation of China(grants 92269203).; The herd immunity against SARS-CoV-2 is continuously consolidated across the world during the ongoing pandemic.However,the potential function of the nonconserved epitopes in the reverse preexisting cross-reactivity in...; 关键词：IMMUNITY CONSERVED assessed

A novel method for identifying SARS-CoV-2 infection mutants via an epitope-specific CD8^(+)T cell test: 《Biosafety and Health》2024年第3期143-152,共10页Congling Qiu Bo Peng Chanchan Xiao Pengfei Chen Lipeng Mao Xiaolu Shi Zhen Zhang Ziquan Lv Qiuying Lv Xiaomin Zhang Jiaxin Li Yanhao Huang Qinghua Hu Guobing Chen Xuan Zou Xiaofeng Liang; the Key Project of Shenzhen Science and Technology Innovation Commission(JCYJ20210324115411030);Natural Science Foundation of China(92169102);R&D Program of Guangzhou Laboratory(SRPG22-006);Sanming Project of Medicine in Shenzhen(SZSM202211023);GuangDong Basic and Applied Basic Research Foundation(2022B1515120043);the Open Project Fund of Guangdong Provincial People’s Hospital(YKY-KF202208);National Natural Science Foundation of China(81902097);Funding by Science and Technology Projects in Guangzhou(SL2023A04J01160);the Guangdong Basic and;Applied Basic Research Foundation(2023A1515140117);the fellowship of China Postdoctoral Science Foundation(2023TQ0136,2023M741379);supported by grants from the National Key Research and Development Plan(2023YFE0118700,2021YFC2301604);the Fundamental Research Funds for the Central Q4 Universities(21623406).; Since the outbreak of the coronavirus disease 2019(COVID-19)epidemic in 2019,the public health system has faced enormous challenges.Tracking the individuals who test positive for severe acute respiratory syndrome coro...; 关键词：Asymptomatic coronavirus disease 2019 (COVID-19) EPITOPES Specific CD8^(+)T cell ELISPOT

SARS-CoV-2 peptides/epitopes for specific and sensitive diagnosis: 《Cellular & Molecular Immunology》2023年第5期540-542,共3页He-Wei Jiang Yang Li Sheng-Ce Tao; the National Key Research and Development Program of China Grant(No.2020YFE0202200);the National Natural Science Foundation of China(Nos.31900112 and 31970130).; The COVID-19 pandemic,caused by SARS-CoV-2,has presented an unprecedented challenge to global public health.The rapid,reliable,and affordable diagnosis of COVID-19 is essential for controlling the spread of the acute ...; 关键词：DIAGNOSIS app false

An antibody cocktail with broadened mutational resistance and effective protection against SARS-CoV-2: 《Science China(Life Sciences)》2023年第1期165-179,共15页Chunyun Sun Hang Chi Fei Yuan Jing Li Ji Yang Aihua Zheng Fei Wang Lingling Sun Yanjing Zhang Ping Hu Lihua Jiao Yongqiang Deng Liangzhi Xie; supported by the National Key Research and Development Project of China(2021YEF0201700)。; Neutralizing antibodies have been proven to be highly effective in treating mild and moderate COVID-19 patients,but continuous emergence of SARS-CoV-2 variants poses significant challenges.Antibody cocktail treatments...; 关键词：SARS-CoV-2 COVID-19 EPITOPES antibody cocktail mutational escape

广州地区209例HLA-Ⅰ类抗体引起的血小板输注无效患者抗体特异性及epitopes分析被引量：4: 《热带医学杂志》2022年第7期941-944,共4页陈扬凯徐秀章叶欣邓晶丁浩强夏文杰邵媛刘静陈大伟许耀日; 广东省自然科学基金(2020A1515011348);广州市科技计划项目(201707010021);广州市医学重点学科建设项目(血液安全重点实验室); 目的了解广州地区人类白细胞抗原(HLA)⁃Ⅰ类抗体所致血小板输注无效(PTR)患者的HLA抗体特异性及高频抗原决定簇。方法采用ELISA方法对209例PTR患者的HLA⁃Ⅰ类抗体进行检测。运用Luminex检测平台,通过HLA特异性抗体检测试剂盒(LIFECODES ...; 关键词：血小板输注无效 HLA-Ⅰ类抗体抗原决定簇

SARS-CoV-2 Epitopes following Infection and Vaccination Overlap Known Neutralizing Antibody Sites被引量：1: 《Research》2022年第2期71-84,共14页Li Yang Te Liang Lane M.Pierson Hongye Wang Jesse K.Fletcher Shu Wang Duran Bao Lii Zhang Zhen Huang Wenshu Zheng Xiaomei Zhang Heewon Park Yuwen Li James E.Robinson Amy K.Fechan Christopher J.Lyon Jing Cao Lisa A.Morici Chenzhong Li Chad J.Roy Xiaobo Yu Tony Hu; supported by the Department of Defense(grant number W8IxwH19i0926);National Institute of Allergy and Infectious Diseases contract(grant number_HHSN2722017000331);National Institute of Child Health and Human Development grant(grant numbers R01HD090927 and R01HDi03511);National Center for Research Resources and the Ofice of Research Infrastructure Programs(grant numbers OD011104).; Identification of epitopes targeted following virus infection or vaccination can guide vaccine design and development of therapeutic interventions targeting functional sites,but can be laborious.Herein,we employed pep...; 关键词：vaccine ANTIBODY LIKELY

Publisher Correction:Epitopes for a 2019-nCoV vaccine: 《Cellular & Molecular Immunology》2021年第10期2460-2460,共1页Guglielmo Lucchese; The article Epitopes for a 2019-nCoV vaccine,written by Guglielmo Lucchese,was originally published Online First without Open Access.After publication in volume 17,pages 539–540,the author decided to opt for Open Cho...; 关键词：originally decided VACCINE

History,epidemiology,vaccine and transmission of coronavirus disease 2019 (COVID-19):a quick review: 《Life Research》2021年第3期9-19,共11页Rabia Altaf Asra Iftikhar Rabia Haq Bushra Zahoor Muhammad Zaini Asmawi Mohamed Khadeer Ahamed Basheer; Coronavirus belonging to family Coronaviridae is a large group of viruses causing respiratory and gastrointestinal diseases.The outbreak of 2019-novel coronavirus has created panic in the whole world after being trans...; 关键词：PANDEMIC Severe acute respiratory syndrome coronavirus-2 Social distance Respiratory illness EPITOPES S-glycoprotein

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