CISPLATIN

作品数：604被引量：1584H指数：17
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PhaseⅡstudy of induction chemotherapy followed by concurrent chemoradiotherapy with raltitrexed and cisplatin in locally advanced nasopharyngeal carcinoma被引量：5
《Chinese Journal of Cancer Research》2020年第5期665-672,共8页Yuan Wu Xueyan Wei Zilong Yuan Hongbin Xu Yanping Li Ying Li Liu Hu Guang Han Yu Qian Desheng Hu 
supported by The Radiation Therapy Major Project of the Ministry of Science and Technology of China(No.2016YFC0105711);supported partly by Natural Science Foundation of China(No.81401913)。
Objective:For locally advanced nasopharyngeal carcinoma(LA-NPC)patients,high incidences of distant metastases and severe treatment related toxicities are the main obstacles needed to be overcome.Raltitrexed,a specific...
关键词：Nasopharyngeal carcinoma RALTITREXED CISPLATIN induction chemotherapy concurrent chemoradiotherapy 
Ethaselen: a novel organoselenium anticancer agent targeting thioredoxin reductase 1 reverses cisplatin resistance in drug-resistant K562 cells by inducing apoptosis被引量：1
《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》2017年第5期373-382,共10页Suo-fu YE Yong YANG Lin WU Wei-wei MA Hui-hui ZENG 
supported in part by the National Natural Science Foundation of China(No.81372266);the National Science and Technology Major Project of the Ministry of Science and Technology of China(No.2011zx09101-001-03)
It has been reported that Ethaselen shows inhibitory effects on thioredoxin reductase（TrxR） activity and human tumor cell growth. In order to find an efficient way to reverse cisplatin resistance, we investigated th...
关键词：Cisplatin resistance CISPLATIN Bcl-2 Cytochrome c ETHASELEN 
Cisplatin-loaded Poly(L-glutamic acid)-g-Methoxy Poly(ethylene glycol) Nanoparticles as a Potential Chemotherapeutic Agent against Osteosarcoma
《Chinese Journal of Polymer Science》2015年第5期763-771,共9页Yi-fei Li Hai-yang Yu Hai Sun 刘建国 汤朝晖 Dan Wang Lian-you Yu Xue-si Chen 
financially supported by the National Natural Science Foundation of China(Nos.51373168,51233004,21104076,51321062 and 51390484);Ministry of Science and Technology of China(International Cooperation and Communication Program 2011DFR51090);the Program of Scientific Development of Jilin Province(Nos.20130206066GX,20130727050YY and 20130521011JH)
Herein, cisplatin-loaded poly（L-glutamic acid）-g-methoxy poly（ethylene glycol） nanoparticles were evaluated as a potential chemotherapeutic agent against osteosarcoma by using alone or with an i RGD（internalizing...
关键词：Nanoparticles Biodegradable polymers Cancer chemotherapy Polymeric drug carrier 
RasGAP-derived peptide GAP159 enhances cisplatin-induced cytotoxicity and apoptosis in HCT116 cells被引量：1
《Acta Pharmaceutica Sinica B》2014年第2期128-134,共7页Hao Zhang Shenghua Zhang Hongwei He Caixia Zhang Yi Chen Dongke Yu Jianhua Chen Rongguang Shao 
This research was supported by grants from National Basic Research Program of China(No.2009CB521807);National Natural Science Foundation of China(Nos.30772583 and 81302802);National S&T Major Special Project on Major New Drug Innovation(No.2012ZX09301-002).
To increase the efficacy of currently used anti-cancer genotoxins,one of the current efforts is to find agents that can sensitize cancer cells to genotoxins so that the efficacious doses of genotoxins can be lowered t...
关键词：GAP159 CDDP CHEMOSENSITIZATION Colon cancer APOPTOSIS 
Role of microRNA-181a in the apoptosis of tubular epithelial cell induced by cisplatin被引量：10
《Chinese Medical Journal》2012年第3期523-526,共4页Zhu Han-yu Liu Mo-yan Hong Quan Zhang Dong Geng Wen-jia Xie Yuan-sheng Chen Xiang-mei 
This work was supported by the National Natural Science Foundation of China （No.61101218 and No.81102673）,the New Star Program of Beijing Science and Technology Commission （No.2011111） and the National Basic Research Program of China （No.2011 CB944004）.
Background Cisplatin （DDP） is one of most effective and most commonly used therapeutic agent in treating tumors,it can accumulate in the kidney and lead to acute renal failure.MicroRNA-181a can induce cell apoptosis...
关键词：MicroRNA-181a CISPLATIN tubular epithelial cell APOPTOSIS 
Effect of Cisplatin on the Flexibility of Linear DNA
《Chinese Physics Letters》2011年第6期344-347,共4页JI Chao ZHANG Ling-Yun HOU Xi-Miao DOU Shuo-Xing WANG Peng-Ye 
by the National Natural Science Foundation of China under Grant No 10834014;the National Basic Research Program of China under Grant No 2009CB930704。
With the aid of an atomic force microscope(AFM),we study the interaction between linear DNA fragment and cisplatin.For different cisplatin concentrations,the AFM used to observe the conformation of DNA has a gradual c...
关键词：CISPLATIN CONCENTRATION CISPLATIN 
RanBPM is an acetylcholinesterase-interacting protein that translocates into the nucleus during apoptosis被引量：2
《Acta Biochimica et Biophysica Sinica》2009年第11期883-891,共9页Xiaowen Gong Weiyuan Ye Haibo Zhou Xiaohui Ren Zhigang Li Weiyin Zhou Jun Wu Yicheng Gong Qi Ouyang Xiaolin Zhao Xuejun Zhang 
Acetylcholinesterase （ACHE） expression may be induced during apoptosis in various cell types. Here, we used the C-terminal of AChE to screen the human fetal brain library and found that it interacted with Ran-bindin...
关键词：ACHE RANBPM yeast two-hybrid CISPLATIN APOPTOSIS 
Enhancement of tumor cell death by combining cisplatin with an oncolytic adenovirus carrying MDA-7/IL-24被引量：6
《Acta Pharmacologica Sinica》2009年第4期467-477,共11页Yu-mei WU Kang-jian ZHANG Xue-tian YUE Yi-qiang WANG Yi YANG Gong-chu LI Na LI Yi-gang WANG 
We thank Prof Xin-yuan LIU for his thorough review and approval of this article and Kan CHEN for her help with cell culture. This work was supported by the Zhejiang Science and Technology Support Plan （No 2007C33027）, National Natural Science Foundation of China （No 30800093, No 30801379）, Science and Technology Commission of Shang- hai Municipality （No 06DZ22032）, National Basic Research Program of China （973 Program, No 2004 CB51804）, Key Project of the Chinese Academy of Science （No KSCX2- YW-R-09, R-04）, and Zhejiang Sci-Tech University Grant 0616033 to ProfXin-yuan LIU.
Aim： The aim of this study was to creatively implement a novel chemo-gene-virotherapeutic strategy and further strengthen the antitumor effect in cancer cells by the combined use of ZD55-IL-24 and cisplafin. Methods...
关键词：CISPLATIN MDA-7/IL-24 oncolytic adenovirus APOPTOSIS 
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