ETHASELEN

作品数：9被引量：9H指数：2
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相关作者：曾慧慧傅佳凝谭强王立辉李静更多>>
相关机构：北京大学沈阳药科大学更多>>
相关期刊：《Journal of Chinese Pharmaceutical Sciences》《Acta Pharmacologica Sinica》《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》更多>>
相关基金：国家自然科学基金国家重点基础研究发展计划北京市自然科学基金更多>>
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Ethaselen: a novel organoselenium anticancer agent targeting thioredoxin reductase 1 reverses cisplatin resistance in drug-resistant K562 cells by inducing apoptosis被引量：1
《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》2017年第5期373-382,共10页Suo-fu YE Yong YANG Lin WU Wei-wei MA Hui-hui ZENG 
supported in part by the National Natural Science Foundation of China(No.81372266);the National Science and Technology Major Project of the Ministry of Science and Technology of China(No.2011zx09101-001-03)
It has been reported that Ethaselen shows inhibitory effects on thioredoxin reductase（TrxR） activity and human tumor cell growth. In order to find an efficient way to reverse cisplatin resistance, we investigated th...
关键词：Cisplatin resistance CISPLATIN Bcl-2 Cytochrome c ETHASELEN 
Dose-biomarker-response modeling of the anticancer effect of ethaselen in a human non-small cell lung cancer xenograft mouse model被引量：2
《Acta Pharmacologica Sinica》2017年第2期223-232,共10页Suo-fu YE Jian LI Shuang-min JI Hui-hui ZENG Wei LU 
This work was supported in part by the National Natural Science Foundation （81372266） and the National Science and Technology Major Project, China （2011zx09101-001-03）.
Thioredoxin reductase （TrxR） is a component of several redox-sensitive signaling cascades that mediate important biological processes such as cell survival, maturation, growth, migration and inhibition of apoptosis....
关键词：non-small cell lung cancer （NSCLC） thioredoxin reductase anticancer drug ETHASELEN dose-biomarker-response model NONMEM 
Different responses of HepG2 subclones to low dose ethaselen
《Journal of Chinese Pharmaceutical Sciences》2016年第4期302-309,共8页张国州 熊堃 马薇薇 徐伟 曾慧慧 
National Natural Science Foundation(Grant No.81372266);National Science and Technology Major Project,People’s Republic of China(Grant No.2011zx09101-001-03)
As a synthesized antineoplastic organoselenium compound, ethaselen is known to induce apoptosis in tumor cells via dose-dependent thioredoxin reductase （TrxR） inhibition. Thioredoxin, the multifunctional biological ...
关键词：Low dose ORGANOSELENIUM Ceil subcloning HETEROGENEITY Tumor cell 
Reactive oxygen species mediate ethaselen-induced rapid apoptosis in A549 cells
《Journal of Chinese Pharmaceutical Sciences》2014年第1期54-59,共6页熊堃 徐伟 曾慧慧 
National Science and Technology Major Project,Peoples’Republic of China(Grant No.2011zx09101-001-03)
Thioredoxin reductase （TrxR） is an important enzyme responsible for the removal of excess reactive oxygen species （ROS） in mammalian cells. This study aimed to investigate the roles of ROS in the anti-tumor effect...
关键词：ETHASELEN Reactive oxygen species ANTI-CANCER APOPTOSIS MITOCHONDRIA 
Development of an HPLC-UV method for the determination of ethaselen in its injection formulation
《Journal of Chinese Pharmaceutical Sciences》2012年第4期321-326,共6页陈粟 宋平 王颖 胡启帜 张烜 张强 
Key Drug Innovation Project of China (Grant No. 2009ZX09102-031)
A novel ethaselen injection formulation has been developed in our laboratory. The objective of the present study was to establish and validate a high performance liquid chromatography （HPLC） method for the determina...
关键词：ETHASELEN INJECTION HPLC CONTENT 
Drug efficacy and pharmacological action of an organoselenium compound ethaselen,a novel antitumor drug被引量：4
《Journal of Chinese Pharmaceutical Sciences》2010年第3期163-168,共6页傅佳凝 王静瑜 王立辉 王磊 唐菀晨 蔡高雄 刘密 曾慧慧 
National Natural Science Foundation of China(Grant No.30472036)
Ethaselen, an organoselenium compound designed and synthesized in the School of Pharmaceutical Sciences, Peking University, has been entitled to independent intellectual property rights both at home and abroad. As one...
关键词：ETHASELEN Organoselenium compounds Antitumor effect Immunologic function Thioredoxin reductase 
Synergistic effect of ethaselen and cisplatin treatment against tumor cell lines被引量：1
《Journal of Chinese Pharmaceutical Sciences》2009年第4期337-341,共5页李静 傅佳凝 谭强 曾慧慧 
National Natural Science Foundation of China (Grant No.30472036).
The antitumor activities of ethaselen （BBSKE） in combination with cisplatin （CDDP） in vitro have been investigated in human stomach cancer cell line BGC 823 and human lung cancer cell line PG-BE1. MTT method was u...
关键词：Ethaselen （BBSKE） Cisplatin （CDDP） Synergistic effect 
Investigation of the redox status in H22 hepatocellular carcinoma xenografts treated by a novel anticancer drug-ethaselen被引量：1
《Journal of Chinese Pharmaceutical Sciences》2009年第3期245-251,共7页王立辉 曾慧慧 
National Natural Science Foundation of China (Grant No.30472036).
We investigated the redox status of H22 hepatocellular carcinoma xenografts treated with various doses of ethaselen, a novel anticancer drug targeting thioredoxin reductase （TrxR）. The concentrations of low molecula...
关键词：ETHASELEN Thioredoxin reductase inhibitor Anticancer drug Redox status Antioxidant system Hepatocellular carcinoma 
Study on the binding of novel antitumor drug Ethaselen to bovine serum albumin
《Journal of Chinese Pharmaceutical Sciences》2009年第2期128-131,共4页唐菀晨 富戈 王煦 张建国 曾慧慧 
National Natural Science Foundation of China (Grant No. 30472036);Beijing Natural Science Foundation (Grant No. 7021001)
The binding pattern of Ethaselen to bovine serum albumin （BSA） was studied by fluorescence spectroscopic technique and Autodock 3.0.5 analysis. The result showed that the binding constant K of Ethaselen and BSA is ...
关键词：Bovine serum albumin ETHASELEN BINDING 
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