PHOSPHOTYROSINE

作品数：7被引量：15H指数：2
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相关领域：医药卫生更多>>
相关作者：孙爱晶裴惠敏贾心善丁俊义张道荣更多>>
相关机构：中国医科大学青岛大学更多>>
相关期刊：《World Journal of Diabetes》《中华病理学杂志》《Chinese Journal of Chemistry》《Cell Research》更多>>
相关基金：国家自然科学基金更多>>
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Assessment of pathogenicity and functional characterization of APPL1 gene mutations in diabetic patients
《World Journal of Diabetes》2024年第2期275-286,共12页Ping Shi Yang Tian Feng Xu Lu-Na Liu Wan-Hong Wu Ying-Zhou Shi An-Qi Dai Hang-Yu Fang Kun-Xia Li Chao Xu 
Supported by the National Natural Science Foundation,No.81974124;and Taishan Scholar Project,No.tsqn20161071.
BACKGROUND Adaptor protein,phosphotyrosine interacting with PH domain and leucine zipper 1(APPL1)plays a crucial role in regulating insulin signaling and glucose metabolism.Mutations in the APPL1 gene have been associ...
关键词：Adaptor protein phosphotyrosine interacting with PH domain and leucine zipper 1 Maturity-onset diabetes of the young Bioinformatics analysis Gene mutation DOMAIN 
A strategy for uncovering germline variants altering anti-tumor CD8 T cell response被引量：1
《Journal of Genetics and Genomics》2023年第5期353-361,共9页Vijay Kumar Ulaganathan Martina H.Vasileva 
Among many factors known to alter the outcomes of T cell receptor(TCR)-induced proximal signaling,the role of human germline variants in dictating the individuality of the anti-tumor CD8 T cell response has remained c...
关键词：Non-synonymous single nucleotide variants(nsSNVs) Membrane-proximal phosphotyrosine signalling motifs Phosphotyrosine-altering non-synonymous single nucleotide variants(pTyr-SNVs) Immunoreceptor tyrosine activation motif(ITAM) CD8 T cells Melanoma B16-F10 
Co-delivery of Cisplatin and Chlorin e6 by Poly(phosphotyrosine)for Synergistic Chemotherapy and Photodynamic Therapy被引量：2
《Chinese Journal of Chemistry》2022年第20期2428-2436,共9页Haisen Zhou Yaoyi Wang Yingqin Hou Zhengkui Zhang Qi Wang Xiaodong Tian Hua Lu 
supported by the National Key Research and Development Program of China(2016YFA0201400);the Na-tional Natural Science Foundation of China for Distinguished Young Investigators(22125101).
Nanoscale drug delivery systems(NDDSs)have emerged as promising carriers for combinational therapy by co-delivery of multiple drugs and modalities.However,most co-delivery systems require the use of complicated materi...
关键词：Drug delivery Poly(phosphotyrosine) Block copolymers Nanoparticles Combinational chemo-photodynamic therapy 
Effects of Okadaic Acid, Retinoic Acid, and Phorbol Myristate Acetate Tumor Promoter on Oncogene Expression被引量：1
《Journal of Cancer Therapy》2014年第6期591-604,共14页John J. Wille Jong Y. Park 
The effect of okadaic acid (OA) on proto-oncogene protein expression of c-neu, c-myc, v-rasH, EGFR, and phosphotyrosine-containing phosphoproteins (P-Tyr) was investigated in rapidly growing (RG) normal human keratino...
关键词：Epidermal KERATINOCYTES Indirect IMMUNOFLUORESCENCE Microscopy ONCOGENE Protein Antibodies Okadaic ACID PHOSPHOTYROSINE Antibody RETINOIC ACID SV-40 Transformed KERATINOCYTES TPA Tumor Promoter 
Viral proteins and Src family kinases: Mechanisms of pathogenicity from a “liaison dangereuse”被引量：6
《World Journal of Virology》2013年第2期71-78,共8页Mario Angelo Pagano Elena Tibaldi Giorgio Palù Anna Maria Brunati 
To complete their life cycle and spread, viruses interfere with and gain control of diverse cellular processes, this most often occurring through interaction between viral proteins(VPs) and resident protein partners. ...
关键词：Interaction PHOSPHOTYROSINE PROLINE-RICH motif SRC HOMOLOGY 2 DOMAIN SRC HOMOLOGY 3 DOMAIN 
EphA3 functions are regulated by collaborating phosphotyrosine residues
《Cell Research》2010年第11期1263-1275,共13页Guanfang Shi Gang Yue Renping Zhou 
Ephrin ligands interact with Eph receptors to regulate a wide variety of biological and pathological processes. Recent studies have identified several downstream pathways that mediate the functions of these receptors....
关键词：tyrosine phosphorylation signal transduction cell migration growth cone collapse 
肺癌癌基因产物C－FOS、C－JUN、Phosphotyrosine表达的研究被引量：5
《中华病理学杂志》1994年第5期264-266,T053,共3页贾心善 张道荣 孙爱晶 丁俊义 裴惠敏 莲井和久 米泽 佐藤荣一 
国家自然科学基金
对９７例肺癌进行了癌基因产物Ｃ－ＦＯＳ、Ｃ－ＪＵＮ、Ｐｈｏｓｐｈｏｔｙｒｏｓｉｎｅ（以下称Ｐ－Ｔｙｒ）的免疫组织化学研究。结果表明：其表达率为Ｃ－ＦＯＳ＜ＣＪＵＮ＜ｐ－Ｔｙｒ。上述三者均可在核、核膜及细胞质内表达。正...
关键词：肺肿瘤 癌基因 产物 免疫组织化学 
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