supported in part by NIH Grant CA191207 and CA277037(L.Z.Li);AG078814 and CA259635(D.Wallace)and DOD Grant W81XWH2210561(D.Wallace).
Adenine nucleotide translocator(ANT)is a mitochondrial protein involved in the exchange of ADP and ATP across the mitochondrial inner membrane.It plays a crucial role in cellular energy metabolism by facilitating the ...
supported by the National Natural Science Foundation of China(No.22077113);Zhejiang Provincial Basic Public Welfare Research Project(No.GF21H300005).
Flavoproteins are proteins that contain a nucleic acid derivative of riboflavin:flavin adenine dinucleotide(FAD)or flavin mononucleotide(FMN).Flavoproteins are involved in a wide array of biological processes,such as ...
Development of the use of favin and nicotinamide-adenine nucleotide fluorescence in monitoringthe redox state of the free mitochondrial NADH/NAD+couple in cels,tissues and organs isreviewed.A break-through was the ide...
supported by the Center of Magnetic Resonance and Optical Imaging(CMROn)--an NIH supported research resource P41RR02305(R.Reddy)。
The heart requires continuous ATP availability that is generated in the mitochondria.Althoughstudies using the cell culture and perfiused organ models have been carried out to investigate thebiochemistry in the mitoch...
supported by U.S.Department of Energy,Grant No.DE-FG02-09ER64798(CLL);National Aeronautics and Space Administration Grant No.NNX09AK25G(CLL);American Cancer Society Grant No.RSG-00-036-04-CNE(CLL);National Institute of Health NIH LAMMP P41 Grant No.R01192(BJT,TBK);National Cancer Institute 2P30CA62203(BJT,TBK).
Two-photon excitedfluorescence(TPEF)spectroscopy and imaging were used to investigate the effects of gamma-irradiation on neural stem and precursor cells(NSPCs).While the observed signal from reduced nicotinamide aden...
provided by the Institute for Regenerative Medicine at University of Pennsylvania with an IRM pilot grant(L.Z.Li).
Redox state mediates embryonic stem cell(ESC)differentiation and thus offers an important complementary approach to understanding the pluripotency of stem cells.NADH redox ratio(NADH/(Fp t NADH)),where NADH is the red...