CITRULLINATION

作品数：9被引量：22H指数：2
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相关领域：医药卫生生物学更多>>
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A programmable CRISPR/dCas9-based epigenetic editing system enabling loci-targeted histone citrullination and precise transcription regulation
《Journal of Genetics and Genomics》2024年第12期1485-1493,共9页Xiaoya Zhang Abhisek Bhattacharya Chunxiang Pu Yan Dai Jia Liu Lang Rao Chaoguang Tian 
funded by the Tianjin Synthetic Biotechnology Innovation Capacity Improvement Project(TSBICIP-CXRC-048)。
Histone citrullination,an important post-translational modification mediated by peptidyl arginine deiminases,is essential for many physiological processes and epigenetic regulation.However,the causal relationship betw...
关键词：HISTONE CITRULLINATION Epigenetic editor Peptidyl arginine deiminase dCas9 
A citrullinated antigenic vaccine in treatment of autoimmune arthritis
《Science Bulletin》2024年第18期2920-2929,共10页Xu Jin Tianya Dong Qian Wang Yang Xie Xiangyu Fang Chaonan Wei Shuyan Liu Xi Zheng Ping Wang Danxue Zhu Lulu Cao Suwei Dong Kechi Fang Chao Zhong Jing Wang Fanlei Hu Zhanguo Li 
supported by the Guangdong Basic and Applied Basic Research Foundation(2020B1515130005);the National Natural Science Foundation of China(82371807,82171773,92374202,and 32141004);the National Key R&D Program of China(2022YFC3602000);the Beijing Nova Program(Z181100006218044 and Z211100002121163)。
Rheumatoid arthritis(RA)is an inflammatory autoimmune disease triggered by antigenic peptides with environmental and genetic risk factors.It has been shown that antigen-specific targeting could be a promising therapeu...
关键词：CitAg CITRULLINATION Collagen typeⅡ Therapeutic vaccine Immune tolerance Rheumatoid arthritis 
Neutrophil-derived PAD4 induces citrullination of CKMT1 exacerbates mucosal inflammation in inflammatory bowel disease被引量：1
《Cellular & Molecular Immunology》2024年第6期620-633,共14页Shuling Wang Yihang Song Zhijie Wang Xin Chang Haicong Wu Ziwei Yan Jiayi Wu Zixuan He Le Kang Wenjun Hu Tian Xia Zhaoshen Li Xingxing Ren Yu Bai 
National Natural Science Foundation of China(No.82100587,No.82170567);National Key R&D Program of China(No.2023YFC2413801,China);Shanghai Sailing Program(No.21YF1458700);China National Postdoctoral Program for Innovative Talents(No.BX20220288);China Postdoctoral Science Foundation(No.2022M720138);Program of Shanghai Academic Research Leader(No.22XD1425000);Deep Blue Project of Naval Medical University(Pilot Talent Plan);Basic Medical Research Project of the First Affiliated Hospital of Naval Medical University(No.2023PY06);“Changying”Talent Program of Changhai Hospital of Naval Medical University,and the“Changjian”Talent Program of Changhai Hospital of Naval Medical University.
Peptidyl arginine deiminase 4(PAD4)plays a pivotal role in infection and inflammatory diseases by facilitating the formation of neutrophil extracellular traps(NETs).However,the substrates of PAD4 and its exact role in...
关键词：Peptidyl-arginine deiminase-4 CITRULLINATION Mitochondrial creatine kinase 1 Intestinal epithelial cells Inflammatory bowel disease 
Cholinergic dysfunction-induced insufficient activation of alpha7 nicotinic acetylcholine receptor drives the development of rheumatoid arthritis through promoting protein citrullination via the SP3/PAD4 pathway
《Acta Pharmaceutica Sinica B》2023年第4期1600-1615,共16页Changjun Lv Minghui Sun Yilei Guo Wenxin Xia Simiao Qiao Yu Tao Yulai Fang Qin Zhang Yanrong Zhu Yusufu Yalikun Yufeng Xia Zhifeng Wei Yue Dai 
supported by the“Double First-Class”University Project(CPU2022QZ31,China)。
Both cholinergic dysfunction and protein citrullination are the hallmarks of rheumatoid arthritis(RA),but the relationship between the two phenomena remains unclear.We explored whether and how cholinergic dysfunction ...
关键词：Rheumatoid arthritis CITRULLINATION Cholinergic dysfunction a7nAChR Peptidylarginine deiminase 4 Specificity protein-3 Collagen-induced arthritis Neuron-macrophage coculture system 
Trim28 citrullination maintains mouse embryonic stem cell pluripotency via regulating Nanog and Klf4 transcription
《Science China(Life Sciences)》2023年第3期545-562,共18页Yaguang Zhang Xiaowen Wan Lei Qiu Lian Zhou Qing Huang Mingtian Wei Xueqin Liu Sicheng Liu Bo Zhang Junhong Han 
supported by the National Natural Science Foundation of China(31972884);the National Key Research and Development Program of China(2018YFC1312300);the National Clinical Research Center for Geriatrics(Z20201007);1·3·5 Project for Disciplines of Excellence,West China Hospital(ZYGD18003);the Postdoctoral Research Project,West China Hospital,Sichuan University(18HXBH068);the Natural Science Foundation of Sichuan,China(2022NSFSC1424)。
Protein citrullination,including histone H1 and H3 citrullination,is important for transcriptional regulation,DNA damage response,and pluripotency of embryonic stem cells(ESCs).Tripartite motif containing 28(Trim28),a...
关键词：CITRULLINATION CHROMATIN embryonic stem cell PLURIPOTENCY Trim28 
Therapeutic ACPA inhibits NET formation: a potential therapy for neutrophil-mediated inflammatory diseases被引量：7
《Cellular & Molecular Immunology》2021年第6期1528-1544,共17页Renato G.S.Chirivi Jos W.Gvan Rosmalen Maarten van der Linden Maximilien Euler Gonny Schmets Galina Bogatkevich Konstantinos Kambas Jonas Hahn Quinte Braster Oliver Soehnlein Markus H.Hoffmann Helmuth H.Gvan Es Jos M.H.Raats 
Feasibility grants from the Dutch government(MTVLA15144 and NITLS14050).
Excessive release of neutrophil extracellular traps(NETs)is associated with disease severity and contributes to tissue injury,followed by severe organ damage.Pharmacological or genetic inhibition of NET release reduce...
关键词：Neutrophil Extracellular Traps AUTOIMMUNITY CITRULLINATION Therapeutic Antibody NET inhibition 
Peptidylarginine deiminases and extracellular vesicles: prospective drug targets and biomarkers in central nervous system diseases and repair被引量：1
《Neural Regeneration Research》2021年第5期934-938,共5页Sigrun Lange 
The work was supported in parts by a University of Westminster start-up grant to SL.
Peptidylarginine deiminases are a family of calcium-activated enzymes with multifaceted roles in physiological and pathological processes,including in the central nervous system.Peptidylarginine deiminases cause post-...
关键词：central nervous system citrullination/deimination COVID-19 ectracellular trap formation extracellular vesicles GLIOBLASTOMA NEURODEGENERATION peptidylarginine deiminases regeneration 
Role of citrullination modification catalyzed by peptidylarginine deiminase 4 in gene transcriptional regulation被引量：2
《Acta Biochimica et Biophysica Sinica》2017年第7期567-572,共6页Qiaoli Zhai Lianqing Wang Peiqing Zhao Tao Li 
This work was supported by a grant from the Natural Science Foundation of Shandong Province （No. ZR2015PH031）.
Peptidylarginine deiminase 4 （PADI4）, a new histone modification enzyme, which converts both arginine and monomethyl-arginine to citrulline, has gained massive attention in recent years as a potential regulator of g...
关键词：peptidylarginine deiminase 4 CITRULLINATION post-translationaL modification transcriptional regulation 
Biomarkers in inflammatory bowel diseases:Current status and proteomics identification strategies被引量：11
《World Journal of Gastroenterology》2014年第12期3231-3244,共14页Tue Bennike Svend Birkelund Allan Stensballe Vibeke Andersen 
Unambiguous diagnosis of the two main forms of inflammatory bowel diseases (IBD): Ulcerative colitis (UC) and Crohn’s disease (CD), represents a challenge in the early stages of the diseases. The diagnosis may...
关键词：Inflammatory bowel disease  Biomarker  Proteomics  Citrullination  Ulcerative colitis  Crohn’ s disease  Posttranslational modification 
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