PRODRUG

作品数：209被引量：333H指数：7
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相关领域：医药卫生更多>>
相关作者：张礼和杨振军赵玉芬陈益崔永梅更多>>
相关机构：北京大学上海大学信息技术有限公司郑州大学更多>>
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相关基金：国家自然科学基金中国博士后科学基金国家重点基础研究发展计划湖北省自然科学基金更多>>
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Sodium cholesterol sulfate mediated mitoxantrone prodrug electrostatic nanocomplexes:achieving the therapeutic efficacy and safety of mitoxantrone
《Science China Chemistry》2025年第3期1185-1198,共14页Erwei Zhao Lingxiao Li Jingyi Zhang Yaqiao Li Rong Chai Bowen Zhang Jialin Xing Minglong Huang Lurong Zhang Xiaohui Pu Zhonggui He Bingjun Sun 
financial support from National Natural Science Foundation of China (82272151,82173766,and 82204318);Liaoning Revitalization Talents Program (XLYC2203083);Shenyang Young and Middle-aged Science and Technology Innovation Talent Support Program (RC220389)。
Forming electrostatic nanocomplexes(ENCs)with counter-ions can improve the delivery efficiency of chemotherapy drugs.However,water-soluble chemotherapy drugs like mitoxantrone(MTO),have limited affinity for counter-io...
关键词：MITOXANTRONE PRODRUG sodium cholesterol sulfate electrostatic nanocomplexes disulfide bond 
A proton-catalyzing prodrug for PDT and glycolysis inhibition-synergistic therapy of tumor in spatiotemporal dimensions
《Science China Chemistry》2024年第9期3162-3178,共17页Miao Li Xueying Sun Xiuqin Ma Yang Tan Xiaoyi Jin Yi Wang Fan Yang Qian Li Honglei Zhan Xiaojun Peng 
supported by the National Natural Science Foundation of China(22108024);the Dalian High-level Talent Innovation Support Program of China(2022RQ016);the Fundamental Research Funds for the Central Universities(DUT22LAB601)。
The reactive oxygen species(ROS)generation from photosensitizer in photodynamic therapy(PDT)is limited by tumor hypoxia.Even type-I photosensitizers,e.g.,sulfur-substituted Nile blue,still rely on oxygen as the main c...
关键词：photodynamic therapy PRODRUG glycolysis inhibition autophagy TUMOR synergistic therapy 
The induction of PANoptosis in KRAS-mutant pancreatic ductal adenocarcinoma cells by a multispecific platinum complex
《Science China Chemistry》2022年第10期1978-1984,共7页Xin Yuan Shuren Zhang Xuanmeng Zhong Hao Yuan Dongfan Song Xiaoyu Wang Hanyang Yu Zijian Guo 
supported by the National Natural Science Foundation of China (21731004,91953201,21907050,22107047);the Natural Science Foundation of Jiangsu Province (BK20202004);the Postdoctoral Research Funding Program of Jiangsu Province (003503);the Excellent Research Program of Nanjing University (ZYJH004)
Oncogenic KRAS reprograms pancreatic ductal adenocarcinoma(PDAC) cells to a state that is awfully resistant to apoptosis.An alternative coping strategy is to trigger a nonapoptotic cell death.Herein,a multi specific p...
关键词：metallodrug pancreatic ductal adenocarcinoma PANoptosis cell death platinum prodrug 
Vascular disrupting agent-induced amplification of tumor targeting and prodrug activation boosts anti-tumor efficacy被引量：1
《Science China Chemistry》2022年第10期1994-2004,共11页Sheng Hong Qian-Xiao Huang Ping Ji Xuan Pang Yunxia Sun Si-Xue Cheng Xian-Zheng Zhang Xuesi Chen 
supported by the National Natural Science Foundation of China (51988102,51833007,22135005,52173136 and 21721005)
Vadimezan,one of the typical vascular disrupting agents(VDAs) currently in clinical trials,has been extensively implemented for cancer research,whereas its clinical efficacy is adversely affected by the inevitable sid...
关键词：tumor therapy PRODRUG vascular disrupting agent TIRAPAZAMINE HYPOXIA 
Engineering molecular self-assembly of theranostic nanoprobes for dual-modal imaging-guided precise chemotherapy
《Science China Chemistry》2021年第11期2045-2052,共8页Chenxu Yan Hongxia Xu Menglan Wu Zijun Zhao Weijun Zhao Jianbin Tang Zhiqian Guo 
supported by the National Natural Science Foundation of China(21878087,21908060);the Innovation Program of Shanghai Municipal Education Commission,Shuguang Program(18SG27)。
Uniting dual-modality of fluorescence and photoacoustic(PA)imaging into theranostic nanoprobes is imperative for spatiotemporally tracking of drug delivery,distribution,and release.Herein,we present a rational design ...
关键词：fluorescence probe near-infrared fluorescence probe photoacoustic imaging SELF-ASSEMBLY PRODRUG 
Hypoxia-activatable nano-prodrug for fluorescently tracking drug release in mice
《Science China Chemistry》2021年第3期499-508,共10页Haidong Li Qichao Yao Zhongji Pu Jeewon Chung Haoying Ge Chao Shi Ning Xu Feng Xu Wen Sun Jianjun Du Jiangli Fan Jingyun Wang Juyoung Yoon Xiaojun Peng 
supported by the National Creative Research Initiative programs of the National Research Foundation of Korea(NRF),the Korean Government(MSIP)(2012R1A3A2048814);the National Natural Science Foundation of China(21421005,21808028);the Natural Science Foundation of Liaoning United Fund(U1608222,U1908202)。
Chemotherapy is one of the commonly used methods to treat various types of cancers in clinic by virtue of its high efficiency and universality. However, strong side effects and low concentration of conventional drugs ...
关键词：NIR fluorescent probe activatable HYPOXIA PRODRUG imaging 
Photocaged prodrug under NIR light-triggering with dual-channel fluorescence: in vivo real-time tracking for precise drug delivery被引量：3
《Science China Chemistry》2018年第10期1293-1300,共8页Zhiqian Guo Yaguang Ma Yajing Liu Chenxu Yan Ping Shi He Tian Wei-Hong Zhu 
supported by The National Natural Science Foundation of China (21788102, 21421004, 21636002, 21622602);National Key Research and Development Program (2016YFA0200300);Scientific Committee of Shanghai (14ZR1409700, 15XD1501400);Fok Ying Tong Education Foundation (142014);Program of Introducing Talents of Discipline to Universities (B16017)
Light-triggered drug delivery system is an effective strategy for precise diagnosis and therapy in cancer treatment. However, it suffers from difficultly balancing the dosimetry of drug with light dose and a lack of i...
关键词：near-infrared cyaninc dye dual-channel fluorescence DRUG-RELEASE photocage tumor targeting 
Theranostic hyaluronic acid prodrug micelles with aggregation- induced emission characteristics for targeted drug delivery被引量：1
《Science China Chemistry》2016年第12期1609-1615,共7页Lin Wang Haoke Zhang Anjun Qin Qiao Jin Ben Zhong Tang Jian Ji 
supported by the Key Science Technology Innovation Team of Zhejiang Province(2013TD02);the National Natural Science Foundation of China(51303154,51573160,21574114);the Fundamental Research Funds for the Central Universities(2016QNA4033)
Theranostic hyaluronic acid(HA) prodrug micelles with pH-responsive drug release and aggregation-induced emission(AIE)properties were prepared by chemical graft of biomimetic phosphorylcholine(PC), anticancer drug dox...
关键词：hyaluronic acid AIE PRODRUG drug delivery 
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