supported by grants from the National Science Foundation of China(No.81974118,82325010);The Shanghai Outstanding Academic Leaders(China)(No.20XD1433300);the Shuguang Project of China(21SG11);the Innovative Research Team of High-level Local Universities in Shanghai,China(No.SHSMU-ZDCX20212700);the Major Natural Science Project of the Scientific Research and Innovation Plan of Shanghai Municipal Commission of Education(China)(No.2023ZKZD17);the Shanghai Research Center for Endocrine and Metabolic Diseases(China)(No.2022ZZ01002);the Shanghai Sixth People’s Hospital Foundation(China)(No.ynqn202105).
Non-alcoholic fatty liver disease(NAFLD)is a hepatic metabolic syndrome arisingfrom lipid metabolic imbalance,with its prevalence increasing globally.In this study,weobserved a significant up-regulation of interferon ...
Alcohol abuse has recently become a serious health concern worldwide,and the incidence of alcoholic liver disease(ALD)is rapidly increasing with high morbidity and mortality.Ferroptosis is a newly recognized form of r...
supported by National Science Foundation of China(Grant No.32271409,82002370,31800806);National Basic Research Program of China(2021YFA1201404);China Postdoctoral Science Foundation(Grant No.2019M661806);Major Project of NSFC(81991514);Natural Science Foundation of Jiangsu Province(Grant No.BK20200117);Jiangsu postdoctoral research support project(Grant No.2021K059A);Program of Innovation and Entrepreneurship of Jiangsu Province,Jiangsu Provincial Key Medical Center Foundation,Jiangsu Provincial Medical Outstanding Talent Foundation,Jiangsu Provincial Medical Youth Talent Foundation and Jiangsu Provincial Key Medical Talent Foundation,the Fundamental Research Funds for the Central Universities(14380493,14380494);Changzhou Sci&Tech Program(Grant No.CJ20220103).
Large bone defects resulting from fractures and disease are a major clinical challenge,being often unable to heal spontaneously by the body’s repair mechanisms.Lines of evidence have shown that hypoxia-induced overpr...