GELATIN

作品数：313被引量：563H指数：10
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Gelatin and lipidoid integrate to create gelasomes to enhance siRNA delivery with low toxicity
《Bioactive Materials》2024年第10期557-570,共14页Abilash Gangula Dhananjay Suresh Agasthya Suresh Babu Zhaohui Li Anandhi Upendran Raghuraman Kannan 
the support of the NCI grant(R01-CA27467701)for funding this project.
RNAi therapeutics possess the potential to cure many uncurable human diseases.For instance,RNAi therapeutics using liposomes showed remarkable survival benefits in patients with liver diseases.However,the extension of...
关键词：doses INTEGRATE RENDER 
Selenomethionine in gelatin methacryloyl hydrogels:Modulating ferroptosis to attenuate skin aging
《Bioactive Materials》2024年第5期495-516,共22页Jiachen Sun Xiaoye Xie Yaoyao Song Tianjun Sun Xinzhu Liu Huageng Yuan Chuanan Shen 
supported from the Program of National Natural Science Foundation of China(82272279,82072169).
During skin aging,the degeneration of epidermal stem cells(EpiSCs)leads to diminished wound healing capabilities and epidermal disintegration.This study tackles this issue through a comprehensive analysis combining tr...
关键词：Chronic wounds PHOTOAGING HYDROGELS Ferroptosis 
3D-printed fish gelatin scaffolds for cartilage tissue engineering被引量：4
《Bioactive Materials》2023年第8期77-87,共11页Abudureheman Maihemuti Han Zhang Xiang Lin Yangyufan Wang Zhihong Xu Dagan Zhang Qing Jiang 
supported by the Key Program of NSFC(81730067);Major Project of NSFC(81991514);Jiangsu Provincial Key Medical Center Foundation,Jiangsu Provincial Medical Outstanding Talent Foundation,Jiangsu Provincial Medical Youth Talent Foundation,and Jiangsu Provincial Key Medical Talent Foundation.The Fundamental Research Funds for the Central Universities(14380493,14380494);the National Natural Science Foundation of China(82102511);the Natural Science Foundation of Jiangsu(BK20210021);Research Project of Jiangsu Province Health Committee(M2021031).
Knee osteoarthritis is a chronic disease caused by the deterioration of the knee joint due to various factors such as aging,trauma,and obesity,and the nonrenewable nature of the injured cartilage makes the treatment o...
关键词：3D printing Fish skin gelatin Sodium alginate Cartilage defect repair Tissue engineering 
Engineering the viscoelasticity of gelatin methacryloyl(GelMA)hydrogels via small“dynamic bridges”to regulate BMSC behaviors for osteochondral regeneration被引量：5
《Bioactive Materials》2023年第7期445-459,共15页Changjiang Liu Qifan Yu Zhangqin Yuan Qianping Guo Xiting Liao Feng Han Tao Feng Guoping Liu Runze Zhao Zhuang Zhu Haijiao Mao Caihong Zhu Bin Li 
This work was supported by National Natural Science Foundation of China(81871805,81925027 and 32130059);Jiangsu Provincial Clinical Orthopedic Center,Key Laboratory of Stem Cells and Biomedical Materials of Jiangsu Province and Chinese Ministry of Science and Technology,the Priority Academic Program Development(PAPD)of Jiangsu Higher Education Institutions.
The dynamic extracellular matrix(ECM)constantly affects the behaviors of cells.To mimic the dynamics of ECM with controllable stiffness and energy dissipation,this study proposes a strategy in which a small molecule,3...
关键词：Viscoelastic hydrogels Dynamic bonds GelMA Dissipation Osteochondral regeneration 
Tissue adhesive hemostatic microneedle arrays for rapid hemorrhage treatment被引量：4
《Bioactive Materials》2023年第5期314-327,共14页Reihaneh Haghniaz Han-Jun Kim Hossein Montazerian Avijit Baidya Maryam Tavafoghi Yi Chen Yangzhi Zhu Solmaz Karamikamkar Amir Sheikhi Ali Khademhosseini 
A.S.would like to acknowledge the financial support from the Canadian Institutes of Health Research(CIHR)through a postdoctoral fellowship as well as the startup fund from The Pennsylvania State University;A.K.would like to acknowledge funding from the National Institutes of Health(1R01EB023052,1R01HL140618,CA257558,DK130566).We acknowledge UCLA CFAR grant 5P30 AI028697 and the UCLA AIDS Institute.The authors thank Profs.S.Li and M.Butte at UCLA for providing cryo-sectioning equipment and lab space for the blood coagulation tests,respectively.The authors also thank Prof.K.J.Lee for his advice on microneedle fabrication.
Blood loss by hemorrhaging wounds accounts for over one-third of~5 million trauma fatalities worldwide every year.If not controlled in a timely manner,exsanguination can take lives within a few minutes.Developing new ...
关键词：HEMOSTAT MICRONEEDLES HEMORRHAGE Bleeding Gelatin methacryloyl Silicate nanoplatelets 
A novel Nanocellulose-Gelatin-AS-IV external stent resists EndMT by activating autophagy to prevent restenosis of grafts
《Bioactive Materials》2023年第4期466-481,共16页Tianshu Chu Qingye Li Chun Dai Xiang Li Xiang Kong Yangming Fan Hongyan Yin Jianjun Ge 
This work gained supports by the Natural Science Foundation of Anhui Province(Grant No.2008085MH240);the Major Science and Technology Project of Anhui Province(Grant No.18030801132);the R&D projects for medical and health institutions of Hefei(Grant No.2021YL002).
Vein grafts are widely used for coronary artery bypass grafting and hemodialysis access,but restenosis remains the"Achilles’heel"of these treatments.An extravascular stent is one wrapped around the vein graft and pro...
关键词：RESTENOSIS Vein graft Extravascular stent NC-Gelatin hydrogel EndMT 
Engineering biomolecular systems: Controlling the self-assembly of gelatin to form ultra-small bioactive nanomaterials被引量：1
《Bioactive Materials》2022年第12期321-336,共16页Dhananjay Suresh Agasthya Suresh Raghuraman Kannan 
The size of nanocarriers determines the biological property of the materials, especially as it relates to intratumoral distribution. Previous research has shown that sizes of 10-50 nm penetrate deep inside the tumor, ...
关键词：Gelatin nanoparticle synthesis Nanocomposite SELF-ASSEMBLY 3D tumor spheroids Ultra-small 
Injectable conductive gelatin methacrylate/oxidized dextran hydrogel encapsulating umbilical cord mesenchymal stem cells for myocardial infarction treatment被引量：9
《Bioactive Materials》2022年第7期119-134,共16页Shuoji Zhu Changjiang Yu Nanbo Liu Mingyi Zhao Zerui Chen Jian Liu Ge Li Huanlei Huang Huiming Guo Tucheng Sun Jimei Chen Jian Zhuang Ping Zhu 
This work was supported by National Key Research and Development Program of China(2018YFA0108700,2017YFA0105602);NSFC Projects of International Cooperation and Exchanges(81720108004);National Natural Science Foundation of China(81974019);the Research Team Project of Natural Science Foundation of Guangdong Province of China(2017A030312007);the key program of guangzhou science research plan(201904020047);the Special Project of Dengfeng Program of Guangdong Provincial People’s Hospital(DFJH201812,KJ012019119,KJ012019423).
Umbilical cord mesenchymal stem cells(UCMSCs)transplantation has been proposed as a promising treatment modality for myocardial infarction(MI),but the low retention rate remains a considerable challenge.Injectable nat...
关键词：GelMA Oxidized dextran Conductivity Stem cell therapy Myocardial infarction 
Tuning gelatin-based hydrogel towards bioadhesive ocular tissue engineering applications被引量：3
《Bioactive Materials》2021年第11期3947-3961,共15页Sina Sharifi Mohammad Mirazul Islam Hannah Sharifi Rakibul Islam Darrell Koza Felisa Reyes-Ortega David Alba-Molina Per H.Nilsson Claes H.Dohlman Tom Eirik Mollnes James Chodosh Miguel Gonzalez-Andrades 
the Boston-KPro research fund and NIH/NEI P30EY003790(Core-PA);R.S.was supported in part by the K99 grant from NIH award no.K99 EY030553;the Center for Nanoscale Systems(CNS),Harvard University,a member of the National Nanotechnology Coordinated Infrastructure Network(NNCI);the National Science Foundation under NSF award no.1541959.F.R-O and D.A-M were supported by the research project ICI19/00006;funded by Instituto de Salud CarlosⅢand co-funded by European Union(ERDF/ESF,"A way to make Europe"/"Investing in your future");F.R-O additionally acknowledges funding from Plan Andaluz de Investigaci´on,Desarrollo e Innovaci´on(PAIDI2020)Fellowship supported by Consejería de Economía,Conocimiento,Empresas y Universidad,Junta de Andalucía co-funded by Fondo Social Europeo de Andalucía 2014-2020.
Gelatin based adhesives have been used in the last decades in different biomedical applications due to the excellent biocompatibility,easy processability,transparency,non-toxicity,and reasonable mechanical properties ...
关键词：Natural-based hydrogel GELATIN Biocompatible Biomimetic BIOADHESIVE Cornea 
Biomimetic Ti-6Al-4V alloy/gelatin methacrylate hybrid scaffold with enhanced osteogenic and angiogenic capabilities for large bone defect restoration被引量：4
《Bioactive Materials》2021年第10期3437-3448,共12页Limin Ma Xiaolan Wang Ye Zhou Xiongfa Ji Shi Cheng Dong Bian Lei Fan Lei Zhou Chengyun Ning Yu Zhang 
This work was supported by National Natural Science Foundation of China(31700880,81972126);Natural Science Foundation of Guangdong Province(2020A1515010827);Science and Technology Planning Project of Guangzhou city(201803010106);The China Postdoctoral Science Foundation(2019M652957);Science and Technology Planning Project of Jiangmen City(2019030102490013068);the High-level Hospital Construction Project(KJ012019100)for financial support.
Titanium-based scaffolds are widely used implant materials for bone defect treatment.However,the unmatched biomechanics and poor bioactivities of conventional titanium-based implants usually lead to insufficient bone ...
关键词：3D printing porous titanium alloys Gelatin methacrylate Angiogenesis OSTEOGENESIS 
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