DIPHOSPHONATE

作品数:12被引量:31H指数:3
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相关领域:医药卫生更多>>
相关作者:张萌萌更多>>
相关机构:吉林大学第四医院更多>>
相关期刊:《World Journal of Clinical Cases》《中国骨质疏松杂志》《Chinese Journal of Structural Chemistry》《Chinese Medical Journal》更多>>
相关基金:国家自然科学基金国家重点基础研究发展计划更多>>
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Technetium-99m-methylene diphosphonate single photon emission computed tomography/computed tomography combined with prostate-specific antigen/free prostate-specific antigen ratio for bone metastasis of prostate cancer被引量:1
《World Journal of Clinical Cases》2024年第20期4082-4090,共9页Jian He Yi-Pu Zhong Shuang Zhang 
BACKGROUND Prostate cancer(PC)is one of the most common malignant tumors in men,and bone metastasis is one of its common complications,which seriously affects the quality of life and prognosis of patients.AIM To inves...
关键词:Matrix metalloproteinase 9 Single photon emission computed tomography Prostate-specific antigen to free prostate-specific antigen ratio Prostate cancer Bone metastasis 
A double-blind, double-dummy, randomized controlled, multicenter trial of ^(99)Tc-methylene diphosphonate in patients with moderate to severe rheumatoid arthritis被引量:7
《Chinese Medical Journal》2021年第12期1457-1464,共8页Qiong Fu Ping Feng Ling-Yun Sun Xiao-Xia Zuo Dong-Bao Zhao Dong-Yi He Hua-Xiang Wu Wei Zhang Wei Zhang Fang Du Chun-De Bao 
funded by the Chengdu Yunke Pharmaceutical Co.,Ltd.
Background:Clinical observational studies revealed that ^(99)Tc-methylene diphosphonate(^(99)Tc-MDP)could reduce joint pain and swollenness in rheumatoid arthritis(RA)patients.This multicenter,randomized,double-blind,...
关键词:Rheumatoid arthritis METHOTREXATE ^(99)Tc-MDP Efficacy Safety 
Ionothermal Synthesis and Structural Characterization of a Novel Open Framework Zinc Diphosphonate with Carboxylate-like Linker
《Chinese Journal of Chemistry》2017年第9期1411-1416,共6页Li Zhang Lei Liu Jinxiang Dong 
This work was financially supported by the National Natural Science Foundation of China (Nos. 21276174, 21322608, 21436008), Shanxi Province Science Foundation for Youths (No. 2014021005), Program for the Innovative Talents of Higher Learning Institutions of Shanxi, and A Foundation for the Author of National Excellent Doctoral Dissertation of PR China (No. 201350).
A novel crystalline zinc diphosphonate, (CH3NH3)4Zn2(xbp)2·H2O, denoted as compound 1, was ionothermally synthesized from tetraethyl-p-xylylenebisphosphonate (Yexbp) and Zn(OAc)2 in a protic eutectic mixture ...
关键词:p-xylylenebisphosphonate ionothermal synthesis deep eutectic mixture coordination polymer crystal structure 
^(99m)TC-Methylene diphosphonate uptake at injury site correlates with osteoblast differentiation and mineralization during bone healing in mice被引量:2
《Bone Research》2015年第2期92-99,共8页Zhendong A Zhong Anderson Peck Shihong Li Jeff Van Oss John Snider Casey J Droscha Tingtung A Chang Bart O Williams 
supported by the Van Andel Research Institute;by a grant to BOW from the NIH/NIAMS (AR053293)
99mTc-Methylene diphosphonate (99mTc-MDP) is widely used in clinical settings to detect bone abnormalities. However, the mechanism of 99mTc-MDP uptake in bone is not well elucidated. In this study, we utilized a mou...
关键词:MDP bone TC-Methylene diphosphonate uptake at injury site correlates with osteoblast differentiation and mineralization during bone healing in mice SPECT 
^(99)Tc-MDP对骨重建的影响被引量:7
《中国骨质疏松杂志》2014年第6期680-682,共3页张萌萌 
双膦酸盐主要用于治疗以破骨细胞活性增加为病理特征的代谢性骨病,包括Paget's骨病(派杰氏病),肿瘤骨转移,恶性肿瘤引起的高钙血症和骨质疏松。从P-O-P结构的焦磷酸盐到P-C-P结构的第三代双膦酸盐,其抗骨吸收的作用随碳链接侧链的延长...
关键词:锝[99Tc]亚甲基二膦酸盐(99Tc-MDP) 骨重建 细胞因子 骨吸收 骨形成 TECHNETIUM [99 Tc] methylene DIPHOSPHONATE (99 Tc-MDP) 
The application progress of diphosphonate in the treatment of breast cancer
《The Chinese-German Journal of Clinical Oncology》2014年第4期197-197,共1页Tao Sun 
It has been proved that diphosphonate can be used in the treatment of skeletal related event(SRE)induced by bone metastasis of breast cancer and the prevention of SRE induced by bone metastasis of breast cancer.Theref...
关键词:二膦酸盐 治疗方案 乳腺癌 应用 诱导 
Effect of dichloromethylene diphosphonate on liver regeneration following thioacetamide-induced necrosis in rats
《World Journal of Hepatology》2013年第7期379-386,共8页Mirandeli Bautista María ngeles Gómez del Rio Juana Benedí María Isabel Sánchez-Reus José A Morales-González Ana María Téllez-López Maricela López-Orozco 
AIM: To study the effect of dichloromethylene diphos-phonate (DMDP), a selective Kupffer cell toxicant in reference to liver damage and postnecrotic liver regeneration in rats induced by sublethal dose thioacetamide (...
关键词:Dichloromethylene DIPHOSPHONATE KUPFFER cells THIOACETAMIDE HEPATOTOXICITY Cell cycle 
Systematic review of atorvastatin for the treatment of Alzheimer's disease被引量:2
《Neural Regeneration Research》2012年第17期1344-1351,共8页Yuan Sun Genfa Wang Zhihong Pan Shuyan Chen 
OBJECTIVE: To assess the clinical efficacy and safety of atorvastatin in the treatment of Alzheimer's disease. DATA SOURCES: Medline (1948/2011-04), Embase (1966/2011-04), Cochrane Library (Issue 3, 2011), Ch...
关键词:Alzheimer's disease DEMENTIA atorvastin DIPHOSPHONATE systematic review neural regeneration 
Evaluation of eikonic characteristic of skeletal metastasis of primary pulmonary carcinoma with ^(99)Tc^m methylene diphosphonate whole-body bone scans被引量:1
《The Chinese-German Journal of Clinical Oncology》2010年第8期435-440,共6页Changyin Wang Xiangyuan Zhang 
Objective: The aim of our study was to explore the eikonic characteristic of skeletal metastasis of primary pul- monary carcinoma. Methods: Whole-body bone scans with 99Tcm methylene diphosphonate were performed in ...
关键词:lung neoplasms neoplasm metastasis bone scan 
The value of ^(99m)Tc methylene diphosphonate bone scintigraphy in diagnosing relapsing polychondritis被引量:2
《Chinese Medical Journal》2006年第13期1129-1132,共4页SHI Xu-hua ZHANG Feng-chun CHEN Li-bo OUYANG Meng 
Relapsing polychondritis (RP) is a recurrent disease involving cartilage mainly of the ear,nose, larynx, trachea, and bronchus. The typical manifestations of the disease in the ear and nose can be easily recognized,...
关键词:relapsing polychondritis ^99mTc methylene diphosphonate bone scintigraphy 
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