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Keratin 1 modulates intestinal barrier and immune response via kallikrein kinin system in ulcerative colitis: 《World Journal of Gastroenterology》2025年第6期62-75,共14页Xiang-Qian Dong Ying-Hui Zhang Juan Luo Mao-Juan Li Lan-Qing Ma Ya-Ting Qi Ying-Lei Miao; Supported by the National Natural Science Foundation of China,No.82160113;the“Xingdian Talents”Support Project of Yunnan Province,No.RLMY20220007;the Yunnan Province Clinical Research Center for Digestive Diseases,No.202102AA100062;the Applied Basic Research Projects of Yunnan Province,No.2019FE001-039.; BACKGROUND External factors in ulcerative colitis(UC)exacerbate colonic epithelial permea-bility and inflammatory responses.Keratin 1(KRT1)is crucial in regulating these alterations,but its specific role in the progre...; 关键词：Keratin 1 Ulcerative colitis Kallikrein kinin system Digestive system diseases Bradykinin High molecular weight kininogen Intestinal barrier function Inflammatory cytokines

Bat-derived oligopeptide LE6 inhibits the contact-kinin pathway and harbors anti-thromboinflammation and stroke potential: 《Zoological Research》2024年第5期1001-1012,共12页Li-Na Cha Juan Yang Jin-Ai Gao Xin Lu Xiao-Long Chang Rebecca Caroline Thuku Qi Liu Qiu-Min Lu Dong-Sheng Li Ren Lai Ming-Qian Fang; supported by the National Natural Science Foundation of China(32200397,23SWAQ09,and 31930015);Yunnan Province Grant(202302AA310032,202302AA310035,and 202003AD150008);Ministry of Science and Technology of China(2018YFA0801403);Chinese Academy of Sciences(SAJC202103 and KFJ-BRP-008-003);New Cornerstone Investigator Program(NCI202238);Kunming Science and Technology Bureau(2022SCP007);Priority Union Foundation of Yunnan Provincial Science and Technology Department and Kunming Medical University(202101AC070461);Basic Research Program of Yunnan Province Science and Technology Department(202301AT070083)。; Thrombosis and inflammation are primary contributors to the onset and progression of ischemic stroke.The contact-kinin pathway,initiated by plasma kallikrein(PK)and activated factor XII(FXIIa),functions bidirectionall...; 关键词：PK FXIIa Anti-thromboinflammation Ischemic stroke therapies OLIGOPEPTIDE

The leaf senescence-promoting transcription factor AtNAP activates its direct target gene CYTOKININ OXIDASE 3 to facilitate senescence processes by degrading cytokinins被引量：3: 《Molecular Horticulture》2021年第1期60-71,共12页Youzhen Hu Bin Liu Huazhong Ren Liping Chen Christopher B.Watkins Su-Sheng Gan; The work was supported by Cornell University.Y.H.and B.L.were funded by scholarships from China Scholars Council.; Cytokinins(CKs)are a class of adenine-derived plant hormones that plays pervasive roles in plant growth and development including cell division,morphogenesis,lateral bud outgrowth,leaf expansion and senescence.CKs as ...; 关键词：ABA ABA-cytokinin crosstalk Aging ARABIDOPSIS Cytokinin metabolism Leaf longevity Plant hormone Senescence-associated genes(SAGs)

Effect of safflower yellow pigment combined with cerebellin on neurological function in patients with ischemic stroke and its mechanism: 《Journal of Hainan Medical University》2019年第7期52-55,共4页Ke-Fei Zhang Bing Wang; Objective: To investigate the effects of safflower yellow pigment combined with cerebellin on neurological function in patients with ischemic stroke and analyze its possible mechanism. Methods: A total of 130 patients...; 关键词：SAFFLOWER yellow pigment CEREBROSIDE KININ NEUROLOGICAL function Ischemic stroke MECHANISM

AB021.The effect of anti-VEGF on retinal inflammation and its relationship with the Kinin system in a rat model of laser-induced choroidal neovascularization: 《Annals of Eye Science》2018年第1期427-427,共1页Olivier Fontaine Soumaya Achana Réjean Couture Mark R.Lesk Elvire Vaucher; Background:The neovascular aged-related macular degeneration(AMD)is the leading cause of legal blindness in the elderly.It is presently treated by anti-VEGF intravitreal injection in order to stop the neovascularizati...; 关键词：Aged-related macular degeneration(AMD) Kinin system

AB029.The role of inducible nitric oxide synthase in deleterious effects of Kinin B1 receptor in diabetic retinopathy: 《Annals of Eye Science》2018年第1期435-435,共1页Rahmeh Othman Elvire Vaucher Réjean Couture; Background:Overexpression of inducible nitric oxide synthase(iNOS)has been reported in diabetic retinopathy(DR).The kinin B1 receptor(B1R)is also overexpressed in DR,and can stimulate iNOS via Gαi/ERK/MAPK pathway.We...; 关键词：Rétinopathie diabétique inducible nitric oxide synthase(iNOS) B1 receptor(B1R)

Role of kallikrein kinin system activation in kidney injury induced by trichloroethylene sensitized mice: 《China Medical Abstracts(Internal Medicine)》2016年第2期11-,共1页刘敏; Objective Through testing the expression of complement C3 fragment C3b and i C3b,C5b-9 as well as indexes of KKS before and after using kallikrein-kinin system inhibitor PKSI-527,observing the relevance between KKS an...; 关键词：KALLIKREIN sensitized COMPLEMENT preliminary observing relevance BLANK Female VENT killed

What have we learned about the kallikrein-kinin and renin-angiotensin systems in neurological disorders?被引量：7: 《World Journal of Biological Chemistry》2014年第2期130-140,共11页Maria da Graa Naffah-Mazzacoratti Telma Luciana Furtado Gouveia Priscila Santos Rodrigues Simōes Sandra Regina Perosa; Supported by Conselho Nacional de Desenvolvimento Científico e Tecnológico(CNPq),Funda o de AmparoàPesquisa do Estado de S o Paulo(FAPESP);and Instituto Nacional de Neurociência Translacional(INNT),Programa de Núcleos de Excelência(PRONEX)(Brazil); The kallikrein-kinin system(KKS) is an intricate endogenous pathway involved in several physiological and pathological cascades in the brain. Due to the pathological effects of kinins in blood vessels and tissues, the...; 关键词：Kallikrein-kinin system Renin-angiotensin system Neurological disorders Alzheimer’ s disease EPILEPSY Parkinson’ s disease

Kallikrein-kinin in stem cell therapy: 《World Journal of Stem Cells》2014年第4期448-457,共10页Julie Chao Grant Bledsoe Lee Chao; Supported by National Institutes of Health,No.HL118516,HL29397 and HL44083; The tissue kallikrein-kinin system exerts a wide spectrum of biological activities in the cardiovascular, renal and central nervous systems. Tissue kallikrein-kinin modulates the proliferation, viability, mobility and...; 关键词：Tissue KALLIKREIN Plasma KALLIKREIN KININ MESENCHYMAL STEM CELLS Endothelial PROGENITOR CELLS Neural STEM CELLS Heart Kidney Brain

Kinin B_2 receptor does not exert renoprotective effects on mice with glycerol-induced rhabdomyolysis: 《World Journal of Nephrology》2014年第3期85-91,共7页Pedro Paulo Gattai Fernando Francisco Pazello Mafra Frederick Wasinski Sandro Soares Almeida Marcos Ant?nio Cenedeze Denise Maria Avancini Costa Malheiros Reury Frank Pereira Bacurau Carlos Castilho Barros Niels Olsen Saraiva Camara Ronaldo Carvalho Araujo; Supported by The National Council of Scientific and Technological Development-CNPq,No.135020/2011-5; AIM： To investigate a potential protective role of the kinin B2 receptor in a glycerol-induced rhabdomyolysis mouse model. METHODS： We separated 28 C57Bl/6 male mice into 4 groups： untreated WT animals, untreated B...; 关键词：KININS acute kidney injury Animal models RHABDOMYOLYSIS Skeletal muscle

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