SPHINGOSINE

作品数：80被引量：236H指数：8
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相关作者：张翼肖琼尹大力徐美林王菁更多>>
相关机构：北京协和医学院首都医科大学天津市胸科医院天津医科大学更多>>
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相关基金：国家自然科学基金广东省自然科学基金北京市自然科学基金国家重点基础研究发展计划更多>>
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The contributions of bacteria metabolites to the development of hepatic encephalopathy
《Liver Research》2023年第4期296-303,共8页Miranda Claire Gilbert Tahereh Setayesh Yu-Jui Yvonne Wan 
the USA National Institutes of Health(NIH)R01CA222490.
Over 20%of mortality during acute liver failure is associated with the development of hepatic encephalopathy(HE).Thus,HE is a complication of acute liver failure with a broad spectrum of neuropsychiatric abnormalities...
关键词：LIVER Gut-liver-brain axis Bile acids(BAs) Bile acid(BA)receptors Farnesoid X receptor(FXR) Takeda G protein-coupled receptor 5(TGR5) Sphingosine-1-phosphate receptor 2 (S1PR2) Brain 
Sphingosine-1-phosphate signaling and the gut-liver axis in liver diseases被引量：4
《Liver Research》2019年第1期19-24,共6页Eric K.Kwong Huiping Zhou 
This work was supported by the USA National Institutes of Health(NIH)grants R01 DK104893 and R01DK-057543;VA Merit Award I01BX004033 and 1I01BX001390;Research Career Scientist Award(IK6BX004477)from the Department of Veterans Affairs.
The liver is the central organ involved in lipid metabolism and the gastrointestinal(GI)tract is responsible for nutrient absorption and partitioning.Obesity,dyslipidemia and metabolic disorders are of increasing publ...
关键词：Sphingosine-1-phosphate(S1P) Sphingosine kinase 2(SphK2) Sphingosine-1-phosphate receptor 2 (S1PR2) Gut-liver axis Liver diseases 
Regulation of bile acid receptor activity被引量：9
《Liver Research》2018年第4期180-185,共6页Yu-Jui Yvonne Wan Lili Sheng 
This study was supported by grants funded by the USA National Institutes of Health(NIH)U01CA179582 and R01 CA222490.
Many receptors can be activated by bile acids(BAs)and their derivatives.These include nuclear receptors farnesoid X receptor(FXR),pregnane X receptor(PXR),and vitamin D receptor(VDR),as well as membrane receptors Take...
关键词：Bile acid receptor Farnesoid X receptor(FXR) G protein-coupled bile acid receptor Takeda G protein receptor 5(TGR5) Sphingosine-1-phosphate receptor 2 (S1PR2) ACETYLATION Methylation GLYCOSYLATION 
Bile acids as global regulators of hepatic nutrient metabolism被引量：3
《Liver Research》2017年第1期10-16,共7页Phillip B.Hylemon Kazuaki Takabe Mikhail Dozmorov Masayuki Nagahashi Huiping Zhou 
This work was supported by the US National Institutes of Health(grants R01DK57543 and R01DK104893).
Bile acids(BA)are synthesized from cholesterol in the liver.They are essential for promotion of the absorption of lipids,cholesterol,and lipid-soluble vitamins from the intestines.BAs are hormones that regulate nutrie...
关键词：Sphingosine-1-phosphate Sphingosine kinase 2 Sphingosine-1-phosphate receptor 2 Fatty liver EPIGENETICS 
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