SPHINGOSINE

作品数：80被引量：236H指数：8
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相关领域：医药卫生更多>>
相关作者：张翼肖琼尹大力徐美林王菁更多>>
相关机构：北京协和医学院首都医科大学天津市胸科医院天津医科大学更多>>
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相关基金：国家自然科学基金广东省自然科学基金北京市自然科学基金国家重点基础研究发展计划更多>>
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S1PR1 serves as a viable drug target against pulmonary fibrosis by increasing the integrity of the endothelial barrier of the lung被引量：3
《Acta Pharmaceutica Sinica B》2023年第3期1110-1127,共18页Mengyao Hao Rong Fu Jun Tai Zhenhuan Tian Xia Yuan Yang Chen Mingjin Wang Huimin Jiang Ming Ji Fangfang Lai Nina Xue Liping Bai Yizhun Zhu Xiaoxi Lv Xiaoguang Chen Jing Jin 
supported by National Key Research&Development Program from the Ministry of Science and Technology of the PRC(No.2019YFE0111800,China);National Natural Science Foundation of China(No.81872923,China);Non-profit Central Research Institute Fund of Chinese Academy of Medical Sciences(No.2021-JKCS-016,China);The Science and Technology Development Fund,Macao SAR(No.0074/2019/AMJ,China).
Idiopathic pulmonary fibrosis(IPF)is a progressive lung disease with unclear etiology and limited treatment options.The median survival time for IPF patients is approximately 2–3 years and there is no effective inter...
关键词：Idiopathic pulmonary fibrosis Endothelial barrier Tight junction Sphingosine-1-phosphate receptor 1 Sphingosine-1-phosphate receptor 1 agonist FTY720 IMMH002 Protein stability 
Unveiling the biological role of sphingosine-1-phosphate receptor modulators in inflammatory bowel diseases被引量：4
《World Journal of Gastroenterology》2023年第1期110-125,共16页Evanthia Tourkochristou Athanasia Mouzaki Christos Triantos 
Inflammatory bowel disease(IBD)is chronic inflammation of the gastrointestinal tract that has a high epidemiological prevalence worldwide.The increasing disease burden worldwide,lack of response to current biologic th...
关键词：Inflammatory bowel disease Sphingosine-1-phosphate Intestinal inflammation T helper 1/T helper 17 Sphingosine 1 phosphate Modulators Immune responses 
Sphingosine-1-Phosphate Protects Against the Development of Cardiac Remodeling via Sphingosine Kinase 2 and the S1PR2/ERK Pathway
《Current Medical Science》2022年第4期702-710,共9页Hui YAN Hu ZHAO Shao-wei YI Hang ZHUANG Dao-wen WANG Jian-gang JIANG Gui-fen SHEN 
supported by the National Natural Science Foundation of China(No.81873505).
Objective:Cardiac remodeling is a common pathological change in various cardiovascular diseases and can ultimately result in heart failure.Thus,there is an urgent need for more effective strategies to aid in cardiac p...
关键词：sphingosine-l-phosphate cardiac remodeling sphingosine kinase 2 sphingosine-1-phosphate receptor extracellular regulated protein kinase 
Vitamin B6 prevents Isocarbophos-induced posterior cerebral artery injury in offspring rats through up-regulating S1P receptor expression
《Acta Biochimica et Biophysica Sinica》2021年第12期1691-1701,共11页Yanhua Liu Kunli Yang Ling Wang Jinfang Yang Yang Wang Hu Luo Peng Li Yaling Yin 
This work was supported by the grants from the National Natural Science Foundation of China(Nos.81874312 and U1804197);the Research Foundation of Henan Province(Nos.202300410308,2018GGJS102,18HASTIT047,ZD2020006,219906,and 192102310083);the Research Foundation of Xinxiang Medical University(Nos.XYBSKYZZ201626,XYB-SKYZZ505319,and YJSCX202041Y).
We have previously reported that the long-term exposure of Isocarbophos,a kind of organophosphorus compounds,induces vascular dementia(VD)in rats.Studies have also shown that organophosphorus compounds have adverse ef...
关键词：sphingosine-1-phosphate(S1P)receptor vitamin B6 ISOCARBOPHOS offspring rats vascular dysfunction 
Blockage of sphingosine-1-phosphate receptor 2 attenuates 2,4-dinitrochlorobenzene-induced atopic dermatitis in mice被引量：2
《Acta Pharmacologica Sinica》2020年第11期1487-1496,共10页Soo-Jin Park Dong-Soon Im 
supported by the Basic Science Research Program of the Korean National Research Foundation funded by the Korean Ministry of Education,Science and Technology(NRF-2019R1A2C1005523).
Sphingosine-1-phosphate(S1P)and its receptors have been implicated in functions of Langerhans cells and atopic dermatitis.In thisstudy,we investigated the roles of S1P receptor type 2(S1P2)in a mouse model of atopic d...
关键词：atopic dermatitis sphingosine-1-phosphate sphingosine-1-phosphate receptor type 2(S1P2) S1pr2 gene-deficient mice bone marrow-derived dendritic cell cytokines 
Down-regulation of miR-155 inhibits inflammatory response in human pulmonary microvascular endothelial cells infected with influenza A virus by targeting sphingosine-1-phosphate receptor 1被引量：2
《Chinese Medical Journal》2020年第20期2429-2436,共8页Si-Mei Shen Hao Jiang Jiang-Nan Zhao Yi Shi 
a grant from the National Nature Science Foundation of China(No.81470206).
Background:Endothelial cells play a key role in the cytokine storm caused by influenza A virus. MicroRNA-155 (miR-155) is an important regulator in inflammation. Its role in the inflammatory response to influenza A in...
关键词：MicroRNA-155 Sphingosine 1-phosphate receptor 1 Influenza A virus Endothelial cells 
Sphingosine-1-phosphate signaling and the gut-liver axis in liver diseases被引量：4
《Liver Research》2019年第1期19-24,共6页Eric K.Kwong Huiping Zhou 
This work was supported by the USA National Institutes of Health(NIH)grants R01 DK104893 and R01DK-057543;VA Merit Award I01BX004033 and 1I01BX001390;Research Career Scientist Award(IK6BX004477)from the Department of Veterans Affairs.
The liver is the central organ involved in lipid metabolism and the gastrointestinal(GI)tract is responsible for nutrient absorption and partitioning.Obesity,dyslipidemia and metabolic disorders are of increasing publ...
关键词：Sphingosine-1-phosphate(S1P) Sphingosine kinase 2(SphK2) Sphingosine-1-phosphate receptor 2 (S1PR2) Gut-liver axis Liver diseases 
Regulation of bile acid receptor activity被引量：9
《Liver Research》2018年第4期180-185,共6页Yu-Jui Yvonne Wan Lili Sheng 
This study was supported by grants funded by the USA National Institutes of Health(NIH)U01CA179582 and R01 CA222490.
Many receptors can be activated by bile acids(BAs)and their derivatives.These include nuclear receptors farnesoid X receptor(FXR),pregnane X receptor(PXR),and vitamin D receptor(VDR),as well as membrane receptors Take...
关键词：Bile acid receptor Farnesoid X receptor(FXR) G protein-coupled bile acid receptor Takeda G protein receptor 5(TGR5) Sphingosine-1-phosphate receptor 2 (S1PR2) ACETYLATION Methylation GLYCOSYLATION 
Bile acids as global regulators of hepatic nutrient metabolism被引量：3
《Liver Research》2017年第1期10-16,共7页Phillip B.Hylemon Kazuaki Takabe Mikhail Dozmorov Masayuki Nagahashi Huiping Zhou 
This work was supported by the US National Institutes of Health(grants R01DK57543 and R01DK104893).
Bile acids(BA)are synthesized from cholesterol in the liver.They are essential for promotion of the absorption of lipids,cholesterol,and lipid-soluble vitamins from the intestines.BAs are hormones that regulate nutrie...
关键词：Sphingosine-1-phosphate Sphingosine kinase 2 Sphingosine-1-phosphate receptor 2 Fatty liver EPIGENETICS 
Bile acids and sphingosine-1-phosphate receptor 2 in hepatic lipid metabolism被引量：17
《Acta Pharmaceutica Sinica B》2015年第2期151-157,共7页Eric Kwong Yunzhou Li Phillip B.Hylemon Huiping Zhou 
supported by A.D.Williams Award (to Huiping Zhou);National Institutes of Health (NIH,No.R01 DK-057543 to Phillip B.Hylemon and Huiping Zhou);supported by VA Merit Awards (No.1BX0013828-01 to Phillip B.Hylemon;No.1I01BX001390 to Huiping Zhou)
The liver is the central organ involved in lipid metabolism. Dyslipidemia and its related disorders, including non-alcoholic fatty liver disease(NAFLD), obesity and other metabolic diseases, are of increasing public h...
关键词：Bile acid Sphingosine-1 phosphate receptor Heptic lipid metabolism 
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