SPHINGOSINE

作品数：80被引量：236H指数：8
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相关领域：医药卫生更多>>
相关作者：张翼肖琼尹大力徐美林王菁更多>>
相关机构：北京协和医学院首都医科大学天津市胸科医院天津医科大学更多>>
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相关基金：国家自然科学基金广东省自然科学基金北京市自然科学基金国家重点基础研究发展计划更多>>
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Approach to loss of response to advanced therapies in inflammatory bowel disease被引量：1
《World Journal of Gastroenterology》2024年第22期2902-2919,共18页Nikil Vootukuru Abhinav Vasudevan 
BACKGROUND Remarkable progress over the last decade has equipped clinicians with many options in the treatment of inflammatory bowel disease.Clinicians now have the unique opportunity to provide individualized treatme...
关键词：Inflammatory bowel disease Ulcerative colitis CROHN BIOLOGICS Interleukin-12 and interleukin-23 inhibitors Alpha-beta7-integrin inhibitors Janus kinase inhibitors Sphingosine-1-phosphate receptor modulators 
The contributions of bacteria metabolites to the development of hepatic encephalopathy
《Liver Research》2023年第4期296-303,共8页Miranda Claire Gilbert Tahereh Setayesh Yu-Jui Yvonne Wan 
the USA National Institutes of Health(NIH)R01CA222490.
Over 20%of mortality during acute liver failure is associated with the development of hepatic encephalopathy(HE).Thus,HE is a complication of acute liver failure with a broad spectrum of neuropsychiatric abnormalities...
关键词：LIVER Gut-liver-brain axis Bile acids(BAs) Bile acid(BA)receptors Farnesoid X receptor(FXR) Takeda G protein-coupled receptor 5(TGR5) Sphingosine-1-phosphate receptor 2 (S1PR2) Brain 
S1PR1 serves as a viable drug target against pulmonary fibrosis by increasing the integrity of the endothelial barrier of the lung被引量：3
《Acta Pharmaceutica Sinica B》2023年第3期1110-1127,共18页Mengyao Hao Rong Fu Jun Tai Zhenhuan Tian Xia Yuan Yang Chen Mingjin Wang Huimin Jiang Ming Ji Fangfang Lai Nina Xue Liping Bai Yizhun Zhu Xiaoxi Lv Xiaoguang Chen Jing Jin 
supported by National Key Research&Development Program from the Ministry of Science and Technology of the PRC(No.2019YFE0111800,China);National Natural Science Foundation of China(No.81872923,China);Non-profit Central Research Institute Fund of Chinese Academy of Medical Sciences(No.2021-JKCS-016,China);The Science and Technology Development Fund,Macao SAR(No.0074/2019/AMJ,China).
Idiopathic pulmonary fibrosis(IPF)is a progressive lung disease with unclear etiology and limited treatment options.The median survival time for IPF patients is approximately 2–3 years and there is no effective inter...
关键词：Idiopathic pulmonary fibrosis Endothelial barrier Tight junction Sphingosine-1-phosphate receptor 1 Sphingosine-1-phosphate receptor 1 agonist FTY720 IMMH002 Protein stability 
Sphingosine-1-phosphate derived from PRP-Exos promotes angiogenesis in diabetic wound healing via the S1PR1/AKT/FN1 signalling pathway被引量：4
《Burns & Trauma》2023年第1期229-244,共16页Tianyi Chen Peiyang Song Min He Shunli Rui Xiaodong Duan Yu Ma David G.Armstrong Wuquan Deng 
supported by the Chongqing Youth High-end Talent Studio(Grant No.ZQNYXGDRCGZS2021008);the fund of Sichuan Provincial Western Psychiatric Association’s CSPC LEADING Scientific Research Project(Grant No.WL2021002);the Natural Science Foundation of Chongqing Municipal Science and Technology Bureau(CSTB2022NSCQ-MSX0489);partially supported by National Institutes of Health,National Institute of Diabetes and Digestive and Kidney Diseases Award Number 1R01124789-01A1;National Science Foundation(NSF)Center to Stream Healthcare in Place(#C2SHiP)CNS Award Number 2052578 awarded to DGA.
Background:Sphingosine-1-phosphate(S1P),a key regulator of vascular homeostasis and angiogenesis,is enriched in exosomes derived from platelet-rich plasma(PRP-Exos).However,the potential role of PRP-Exos-S1P in diabet...
关键词：EXOSOMES Platelet-rich plasma Diabetic foot ulcer Wound healing Sphingosine-1-phosphate 
Unveiling the biological role of sphingosine-1-phosphate receptor modulators in inflammatory bowel diseases被引量：4
《World Journal of Gastroenterology》2023年第1期110-125,共16页Evanthia Tourkochristou Athanasia Mouzaki Christos Triantos 
Inflammatory bowel disease(IBD)is chronic inflammation of the gastrointestinal tract that has a high epidemiological prevalence worldwide.The increasing disease burden worldwide,lack of response to current biologic th...
关键词：Inflammatory bowel disease Sphingosine-1-phosphate Intestinal inflammation T helper 1/T helper 17 Sphingosine 1 phosphate Modulators Immune responses 
Sphingosine-1-Phosphate Protects Against the Development of Cardiac Remodeling via Sphingosine Kinase 2 and the S1PR2/ERK Pathway
《Current Medical Science》2022年第4期702-710,共9页Hui YAN Hu ZHAO Shao-wei YI Hang ZHUANG Dao-wen WANG Jian-gang JIANG Gui-fen SHEN 
supported by the National Natural Science Foundation of China(No.81873505).
Objective:Cardiac remodeling is a common pathological change in various cardiovascular diseases and can ultimately result in heart failure.Thus,there is an urgent need for more effective strategies to aid in cardiac p...
关键词：sphingosine-l-phosphate cardiac remodeling sphingosine kinase 2 sphingosine-1-phosphate receptor extracellular regulated protein kinase 
The role of sphingosine-1-phosphate in bone remodeling and osteoporosis被引量：10
《Bone Research》2022年第2期265-273,共9页Justus M.Grewe Paul-Richard Knapstein Antonia Donat Shan Jiang Daniel JSmit Weixin Xie Johannes Keller 
funded by grants to JK by the Else-Kr?ner-Fresenius-Stiftung (EKFS 2017_A22);by grants to JK from the Berlin Institute of Health
Osteoporosis is a systemic bone disease that affects more than 200 million people worldwide and is caused by the disruption of the equilibrium between osteoclastic bone resorption and osteoblastic bone formation. Sphi...
关键词：OSTEOPOROSIS METABOLISM expression. 
Down-regulation of miR-155 inhibits inflammatory response in human pulmonary microvascular endothelial cells infected with influenza A virus by targeting sphingosine-1-phosphate receptor 1被引量：2
《Chinese Medical Journal》2020年第20期2429-2436,共8页Si-Mei Shen Hao Jiang Jiang-Nan Zhao Yi Shi 
a grant from the National Nature Science Foundation of China(No.81470206).
Background:Endothelial cells play a key role in the cytokine storm caused by influenza A virus. MicroRNA-155 (miR-155) is an important regulator in inflammation. Its role in the inflammatory response to influenza A in...
关键词：MicroRNA-155 Sphingosine 1-phosphate receptor 1 Influenza A virus Endothelial cells 
Sphingosine-1-phosphate signal transducer and activator of transcription 3 signaling pathway contributes to baicalein-mediated inhibition of dextran sulfate sodium-induced experimental colitis in mice被引量：6
《Chinese Medical Journal》2020年第3期292-300,共9页Jing Yao Tao Liu Rui-Jiao Chen Jing Liang Jun Li Chuan-Gong Wang 
This work was supported by the grants from the National Natural Science Foundation of China(Nos.81603143,21807041);Shandong Medical and Health Science and Technology Development Project(Nos.2017WS646,2017WS653);Teachers'Research Support Fund of Jining Medical University(No.JYFC2018KJ037);National Natural Science Foundation Breeding Programs of Jining Medical University(No.JYP201708).
Background:Baicalein has been shown to have anti-inflammatory and anti-tumor activities.However,the mechanisms underlying its anti-inflammatory effect on colitis remain unclear.Methods:A dextran sodium sulfate(DSS)-in...
关键词：BAICALEIN COLITIS STAT3 SPHINGOSINE kinase 1 
Sphingosine-1-phosphate signaling and the gut-liver axis in liver diseases被引量：4
《Liver Research》2019年第1期19-24,共6页Eric K.Kwong Huiping Zhou 
This work was supported by the USA National Institutes of Health(NIH)grants R01 DK104893 and R01DK-057543;VA Merit Award I01BX004033 and 1I01BX001390;Research Career Scientist Award(IK6BX004477)from the Department of Veterans Affairs.
The liver is the central organ involved in lipid metabolism and the gastrointestinal(GI)tract is responsible for nutrient absorption and partitioning.Obesity,dyslipidemia and metabolic disorders are of increasing publ...
关键词：Sphingosine-1-phosphate(S1P) Sphingosine kinase 2(SphK2) Sphingosine-1-phosphate receptor 2 (S1PR2) Gut-liver axis Liver diseases 
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