Crohn’s disease(CD)is a chronic inflammatory disorder characterized by dysregulated immune responses and significant disruption of intestinal immunity.A recent case-control study by Andreu-Ballester et al revealed de...
Natural Science Foundation of China(to M.Y.,82271754 and 82071737,to Z.Y.,32030036,to Q.Y.,32000615,and to P.F.,82301974);China Postdoctoral Science Foundation(to P.F.,2023M741377);Guangdong Basic and Applied Basic Research Fund(to Q.Y.,2023A1515012582,to P.F.,2022A1515110217,and to G.C.,2023B1515020018);111 Project(to Z.Y.,B16021).
γδT cells play a crucial role in immune surveillance and serve as a bridge between innate and adaptive immunity.However,the metabolic requirements and regulation ofγδT-cell development and function remain poorly u...
supported by the National Natural Science Foundation of China(Nos.81600151,81302039 and 82060040).
Objective:To retrospectively analyze the expression and significance ofγδT cells and lymphocyte subsets in peripheral blood on patients with multiple myeloma(MM).Methods:Fifty-five patients with multiple myeloma adm...
partially supported by the National Natural Science Foundation of China(82002787,Y.H.,32270950,Y.Z.W.);the Key Program of the National Natural Science Foundation of China(32030036,Z.N.Y.);the Startup Foundation of the Zhuhai People’s Hospital(YNXM20210305,Y.Z.W.);Y.S.L.is supported by the Major International(Regional)Joint Research Program of the National Natural Science Foundation of China(81920108027);D.K.is supported by Deutsche Forschungsge-meinschaft(Ka 502/19-3).
The intricacy of diseases,shaped by intrinsic processes like immune system exhaustion and hyperactivation,highlights the potential of immune renormalization as a promising strategy in disease treatment.In recent years...
This work was supported by grants from the State Key Program of the National Natural Science Foundation(81930086 and 82120108012 to BS,82073157 and 81600487 to WT);the Science and Technology Project of Jiangsu Province(BE2018603 to BS);the Postgraduate Innovative Research Program of Jiangsu Province(KYCX20_0047 to QH).
The specification of theαβ/γδlineage and the maturation of medullary thymic epithelial cells(mTECs)coordinate central tolerance to self-antigens.However,the mechanisms underlying this biological process remain poo...