癌症治疗

作品数:1768被引量:2250H指数:19
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相关领域:医药卫生更多>>
相关作者:何耀马胜林季晓媛何裕民杨金亮更多>>
相关机构:中国科学院苏州大学中国科学技术大学四川大学更多>>
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相关基金:国家自然科学基金中国博士后科学基金国家重点基础研究发展计划辽宁省自然科学基金更多>>
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肿瘤类器官在癌症治疗中的协同应用、当前挑战和未来前景
《癌症》2024年第10期445-469,共25页屈晶晶 Farhin Shaheed Kalyani 刘利 程田力 陈利军 
患者来源的癌细胞(patient-derived cancer cells,PDCs)和患者来源的异种移植模型(patientderived xenografts,PDXs)作为常用的肿瘤模型存在许多不足。PDCs不仅在细胞类型、空间组织和微环境方面缺乏多样性,而且对干细胞培养也有不利影...
关键词:癌症类器官 药物筛选 个性化用药 预后生物标志物 器官芯片 3D生物打印 肿瘤微环境 癌间质 
肠道微生物组在肿瘤发生中的作用和在癌症治疗中的应用被引量:1
《癌症》2023年第7期319-351,共33页李孟鸿 
国家重点研发计划(2020YFA0803300和2018YFC0910300);国家自然科学基金(81630072);深圳市政府(KQTD20170810160226082)的支持
研究表明,肠道菌群失调会导致生理变化,并与包括癌症在内的许多疾病有关。因此,应该在微生物组的背景下研究许多癌症类别和治疗方案。由于宏基因组测序和多组学研究的可用性,对肠道微生物群的物种特征、宿主遗传变化和代谢谱的分析变得...
关键词:癌症生物标志物 化疗 粪便微生物群移植 肠道微生物组 免疫疗法 微生物群 益生菌 
用于预测癌症患者临床治疗方案的小鼠mini人源肿瘤异种移植模型的建立
《癌症》2019年第4期165-176,共12页Feifei Zhang Wenjie Wang Yuan Long Hui Liu Jijun Cheng Lin Guo Rongyu Li Chao Meng Shan Yu Qingchuan Zhao Shun Lu Lili Wang Haitao Wang Danyi Wen 
背景与目的患者来源的类器官(patient-derived organoids,PDOs)和异种移植物(patientderivedxenografts,PDXs)具有较强的预测抗癌药物药效的能力,是功能检测的重要模型。然而,移植失败、构建PDX模型和随后检测药效的耗时过长、体外器官...
关键词:个体化癌症治疗 癌症精准医学 患者来源异种移植(PDX) MiniPDX 药物反应 体内 
Fertility preservation in female cancer patients:a single center experience被引量:7
《Chinese Journal of Cancer》2015年第1期56-60,共5页Cristina Sigismondi Enrico Papaleo Paola Viganò Simona Vailati Massimo Candiani Jessica Ottolina Valentina E. Di Mattei Giorgia Mangili 
Advances in cancer treatment allow women to be cured and live longer. However, the necessary chemotherapy and radiotherapy regimens have a negative impact on future fertility. Oncofertility has emerged as a new interd...
关键词:癌症患者 生育功能 癌症治疗 女性 冷冻保存 中枢神经系统 平均时间 卵巢组织 
Cancer immunotherapy in clinical practice—the past,present,and future被引量:17
《Chinese Journal of Cancer》2014年第9期445-457,共13页Gaurav Goel Weijing Sun 
Considerable progress has been made in the field of cancer immunotherapy in recent years. This has been made possible in large part by the identification of new immune-based cellular targets and the development of nov...
关键词:癌症治疗 免疫疗法 临床实践 免疫治疗 免疫系统 临床试验 肿瘤学 微环境 
The role of EPH receptors in cancer-related epithelial-mesenchymal transition被引量:7
《Chinese Journal of Cancer》2014年第5期231-240,共10页Rui-Xin Li Zi-Hua Chen Zhi-Kang Chen 
Erythropoietin-producing hepatoma(EPH) receptors are considered the largest family of receptor tyrosine kinases and play key roles in physiological and pathologic processes in development and disease.EPH receptors are...
关键词:受体酪氨酸激酶 恶性肿瘤 上皮 转化 间质 促红细胞生成素 信号通路 癌症治疗 
Investigating evolutionary perspective of carcinogenesis with single-cell transcriptome analysis
《Chinese Journal of Cancer》2013年第12期636-639,共4页Xi Zhang Cheng Zhang Zhongjun Li Jiangjian Zhong Leslie P.Weiner Jiang F.Zhong 
supported by Grant R01CA164509 and R21CA134391 from the National Institutes of Health, USA (JFZ), DBI- 0852720 and CHE-1213161 from the National Science Foundation, USA (JFZ)
We developed phase-switch microfluidic devices for molecular profiling of a large number of single cells.Whole genome microarrays and RNA-sequencing are commonly used to determine the expression levels of genes in cel...
关键词:单细胞 转录组 进化观 组分 癌变 癌症治疗 细胞裂解液 单个细胞 
Small interfering RNA-based molecular therapy of cancers被引量:5
《Chinese Journal of Cancer》2013年第9期488-493,共6页Wei Guo Wangbing Chen Wendan Yu Wenlin Huang Wuguo Deng 
RNA interference(RNAi)has become a gold standard for validating gene function in basic life science research and provides a promising therapeutic modality for cancer and other diseases.This minireview focuses on the p...
关键词:小干扰RNA 癌症治疗 SIRNAS 分子 RNA干扰 金纳米粒子 科学研究 基因功能 
Targeted therapy: tailoring cancer treatment
《Chinese Journal of Cancer》2013年第7期363-364,共2页Min Yan Quentin Qiang Liu 
Targeted therapies include small-molecule inhibitors and monoclonal antibodies, have made treatment more tumor-specific and less toxic, and have opened new possibilities for tailoring cancer treatment. Nevertheless, t...
关键词:癌症治疗 靶向治疗 剪裁 单克隆抗体 生物标志物 分子鉴定 信号通路 分子机制 
The VEGF signaling pathway in cancer: the road ahead被引量:14
《Chinese Journal of Cancer》2013年第6期297-302,共6页Steven A. Stacker Marc G. Achen 
funded partly by a program grant from the National Health and Medical Research Council of Australia(NH&MRC);supported by Senior Research Fellowships from the NH&MRC;support of the Pfizer Australia Fellowship
The vascular endothelial growth factor (VEGF) family of soluble protein growth factors consists of key mediators of angiogenesis and lymphangiogenesis in the context of tumor biology. The members of the family, VEGF-A...
关键词:VEGF-C 癌症治疗 信号通路 血管内皮生长因子 EGF家族 肿瘤生物学 道路 胎盘生长因子 
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