PATHOGENIC

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A β-sheet-targeted theranostic agent for diagnosing and preventing aggregation of pathogenic peptides in Alzheimer’s disease被引量：1
《Science China Chemistry》2020年第1期73-82,共10页Xiang Ma Yanqing Wang Jiai Hua Congyu Xu Tao Yang Jian Yuan Guiquan Chen Zijian Guo Xiaoyong Wang 
supported by the National Natural Science Foundation of China(21877059,31570809,21731004);the National Basic Research Program of China(2015CB856300);the Natural Science Foundation of Jiangsu Province(BK20150054);the Research Foundation of the Chinese State Key Laboratory of Coordination Chemistry(SKLCC1912)
Amyloid-βpeptide(Aβ)aggregates,particularly Aβoligomers,are established biomarker and toxic species in Alzheimer’s disease(AD).Early detection and disaggregation of Aβaggregates are of great importance for the tr...
关键词：Alzheimer’s disease theranostic agent amyloid-βpeptide fluorescent probe blood screening 
Ion Channel Genes and Epilepsy:Functional Alteration,Pathogenic Potential,and Mechanism of Epilepsy被引量：25
《Neuroscience Bulletin》2017年第4期455-477,共23页Feng Wei Li-Min Yan Tao Su Na He Zhi-Jian Lin Jie Wang Yi-Wu Shi Yong-Hong Yi Wei-Ping Liao 
supported by the National Natural Science Foundation of China (81571273,81571274,81501124,81271434,and 81301107);Omics-based precision medicine of epilepsy being entrusted by Key Research Project of the Ministry of Science and Technology of China (2016YFC0904400);the Natural Science Foundation of Guangdong Province,China (2014A030313489);Science and Technology Planning Projects of Guangdong Province,China (2012B031800404 and 2013B051000084);the Department of Education of Guangdong Province,China (2013CXZDA022,2013KJCX0156,and 2012KJCX009);the Foundation for High-level Talents in Higher Education of Guangdong Province,China (2013-167);Yangcheng Scholar Research Projects of Guangzhou Municipal College (12A016S and 12A017G);Science and Technology Projects of Guangzhou,Guangdong Province,China (2014J4100069,201508020011,201604020161,and 201607010002)
Ion channels are crucial in the generation and modulation of excitability in the nervous system and have been implicated in human epilepsy. Forty-one epilepsyassociated ion channel genes and their mutations are system...
关键词：EPILEPSY Ion channel gene Epilepsy gene GENETICS Gene function Pathogenic mechanism 
Autophagy protects C.elegans against necrosis during Pseudomonas aeruginosa infection
《Science Foundation in China》2015年第1期53-53,共1页
support by the National Natural Science Foundation of China(Grant No.311171365);National Basic Research Program of China(Grant No.2013CB127500)
Profs.Zhang Keqin and Zou Chenggang from the School of Life Sciences,Yunnan University,reported a previously unidentified role of autophagy in protection against necrosis triggered by pathogenic bacteria in the metazo...
关键词：PATHOGENIC triggered AUTOPHAGY defense INNATE eliminate maintenance IMPAIRMENT homeostasis immunity 
Disposable paper-based bipolar electrode array for multiplexed electrochemiluminescence detection of pathogenic DNAs被引量：2
《Science China Chemistry》2015年第5期810-818,共9页Qiumei Feng Hongyuan Chen Jingjuan Xu 
supported by the National Basic Research Program of China(2012CB932600);the National Natural Science Foundation of China(21327902,21475058,21121091)
A novel disposable paper-based bipolar electrode （BPE） array is fabricated for multiplexed electrochemiluminescence （ECL） detection of pathogenic DNAs. This proposed BPE array device consists of 15 units, each con...
关键词：paper-based device bipolar electrode array pathogenic DNAs multiple detection ELECTROCHEMILUMINESCENCE 
Rapid Identification of Bacterial Species Associated with Bronchiectasis via Metagenomic Approach被引量：5
《Biomedical and Environmental Sciences》2014年第11期898-901,共4页YANG Dong Hong ZHANG Yuan Yuan DU Peng Cheng XU Li WANG Hai Yin HAN Na CHEN Chen GAO Zhan Cheng 
supported by grants from the Ministry of Science and Technology of China(National High-Tech R&D program:No.2006AA02Z4A9 and No.2012BAI05B02;12th Five-Year Plan Major Scientific and Technological Program:No.2012ZX10004-206);the Ministry of Health of China(Special Fund for Health-scientific Research in the Public Interest Program:No.201202011)
Bronchiectasis is a chronic lung disorder and a number of bacterial pathogens are involved.However,30%-40% of sputum and purulent samples in good quality failed to grow any pathogenic bacteria,making it difficult to c...
关键词：pathogenic exacerbation meaningful earlier Junior giving airway routine Species Associated 
The molecular pathogenic role of inflammatory stress in dysregulation of lipid homeostasis and hepatic steatosis被引量：3
《Genes & Diseases》2014年第1期106-112,共7页Yaxi Chen Zac Varghese Xiong Z.Ruan 
This study was supported by Major State Basic Research Development Program of China(973 Program,NO.2012CB517700&2012CB517500);the National Natural Science Foundation of China(81270493,81270789,81200567 and Key Program,No.81030008,81390354);the Moorhead Trust,the Royal Free Hospital Special Trustees Grant-115 through Dr.Zac Varghese,and Kidney Research UK(RP37/2008).
Non-alcoholic Fatty Liver Disease(NAFLD)is becoming the leading cause of chronic liver injury in developed countries and China.Chronic systemic inflammation plays a decisive role and is fundamental in the progression ...
关键词：Ectopic lipid deposition Inflammation Lipid homeostasis Lipid redistribution Non-alcoholic fatty liver disease 
Prevention and Treatment of Chinese Herbal Preparation Yinqiaotiangan against Pathologic Model of Streptococcus suis Serotype II in Kunming Mice被引量：1
《Agricultural Biotechnology》2013年第1期48-51,共4页Hong JIANG Shuhong HUANG Hongjun WANG Tiezhong ZHOU Zhuohui MA 
Supported by Youth Science and Technology Start-up Fund of Liaoning Medical University(Y2012Z023);Project of Agricultural Science and Technology Achievement Transformation from the Ministry of Science and Technology of China(2012GB2B000097)
[ Objectlve] This study aimed to investigate the antimicrobial effect of Chinese herbal preparation Yinqiaotiangan against Streptococcus suis serotype II in vivo. [ Method ] The prevention and treatment tests were con...
关键词：Yinqiaotiangan Streptococcus suis serotype II Pathogenic model Kunming mice 
Construction and characterization of a fosmid library for pathogenic bacterium Vibrio anguillarum被引量：1
《Chinese Journal of Oceanology and Limnology》2009年第3期519-526,共8页韩一凡 莫照兰 茅云翔 肖鹏 李杰 郝斌 郭东升 
Supported by the National Basic Research Program of China (973 Program)(No 2006CB101803);the High Technology Research and development Program of China (863 Program)(No 2006AA6100310);the National Natural Science Foundation of China (No 30871935)
Vibrio anguillarum is a common bacterial pathogen in fish.However,little is known about its pathogenic mechanism,in part,because the entire genome has not been completely sequenced.We constructed a fosmid library for ...
关键词：end-sequencing fosmid library PCR screening Vibrio anguillarum 
Molecular Characterization of a Highly Pathogenetic Porcine Reproductive and Respiratory Syndrome Virus Variant in Hubei, China被引量：2
《Virologica Sinica》2009年第1期9-18,共10页Yi HUANG Bing ZHANG Zhen-fang FU Simon Rayner Fang-liang ZHENG Wang-wang LIANG Ke-li YANG Di-ping XU Han-zhong WANG 
supported in part by a National Key Technologies R&D Program (2006BAD06A01) ;National "973 Project" (2005CB523000, 2006CB- 933102) from the Ministry of Science and Technology, People’s Republic of China.
Porcine reproductive and respiratory syndrome virus (PRRSV) has been recognized as one of the most important pathogens of pigs throughout the world. In 2006, more than 10 provinces of China have experienced an epizoot...
关键词：Porcine reproductive and respiratory syndrome virus （PRRSV） High pathogenic variant GP5  N  NSP2  phylogenetic analysis 
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