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Gene therapy for spinal muscular atrophy:perspectives on the possibility of optimizing SMN1 delivery to correct all neurological and systemic perturbations
《Neural Regeneration Research》2025年第7期2011-2012,共2页Sharon J.Brown Rafael J.Yáñez-Muñoz Heidi R.Fuller 
supported by the Faculty Research Fund(Faculty of Medicine&Health Science,Keele University)Career Development Award–(April 2022)(to SJB)。
Spinal muscular atrophy(SMA)is a genetic condition that results in selective lower motor neuron loss with concomitant muscle weakness and atrophy.The genetic cause of SMA was understood in 1995 when loss or impairment...
关键词：ATROPHY traditionally absolute 
Glucose metabolism perturbations influence tumor microenvironments via LINC01139 pathway and facilitate immunotherapy in hepatocellular carcinoma
《Genes & Diseases》2025年第2期48-51,共4页Yueying Gao Jinyang Yu Zhi Li Kefan Liu Jiwei Pan Ya Zhang Yanlin Ma Jiwei Zhang Zhigang Liu Yongsheng Li 
supported by the National Natural Science Foundation of China (No.32322020,32170676,31970646,32060152);the Natural Science Foundation of Heilongjiang Province,China (Key Program,No.ZD2023C007);Heilongjiang Touyan Innovation Team Program (China);the specific research fund of The Innovation Platform for Academicians of Hainan Province,China;the project supported by Hainan Province Clinical Medical Center (China).
Hepatocellular carcinoma(HCC)is one of the most common tumors with high prevalence and death rate,which lacks effective targeting and immunotherapy currently.Metabolic reprogramming,which provides an inherent advantag...
关键词：METABOLISM IMMUNOTHERAPY PROGRAMMING 
Influence of 3D helical magnetic perturbations on runaway electron generation in J-TEXT tokamak
《Plasma Science and Technology》2025年第3期36-44,共9页Wei YAN Guinan ZOU Zhongyong CHEN You LI Jiangang FANG Zhifang LIN Zhonghe JIANG Nengchao WANG Bo RAO Yangbo LI Zhengkang REN Chuanxu ZHAO Yu ZHONG Fanxi LIU Yinlong YU Zisen NIE Xun ZHOU Yuan SHENG Yuwei SUN Song ZHOU Xiaoqing ZHANG Zhoujun YANG Zhipeng CHEN Yonghua DING the J-TEXT Team 
supported by the National Magnetic Confinement Fusion Energy R&D Program of China (Nos.2018YFE0309103 and 2019YFE03010004);National Natural Science Foundation of China (Nos.12475222,12205122,and 51821005);Hubei International Science and Technology Cooperation Projects (No.2022EHB003)。
A large number of runaway electrons(REs)generated during disruption can cause significant damage to next-generation large-scale tokamaks.The influence of three-dimensional(3D)helical magnetic perturbations on the supp...
关键词：3D helical magnetic perturbations runaway electron J-TEXT tokamak 
Interactions between Initial and Lateral Boundary Perturbations in Convection-Permitting Ensemble Prediction
《Journal of Meteorological Research》2025年第1期116-131,共16页Jingzhuo WANG Jing CHEN Fajing CHEN Yanan Ma 
Supported by the National Natural Science Foundation of China(U2242213 and 42105154).
How to construct appropriate perturbations for convection-permitting ensemble prediction systems(CPEPSs)is a critical issue awaiting urgent solutions.As two common perturbations,initial perturbations(IPs)and lateral b...
关键词：INTERACTIONS initial perturbations lateral boundary perturbations convection-permitting ensemble prediction 
Predictions of H-mode access and edge pedestal instability in the EHL-2 spherical torus
《Plasma Science and Technology》2025年第2期54-63,共10页Yumin WANG Kai LI Zhuo HUANG Yiliang LIU Shuyu DAI Jie ZHANG Yanqing HUANG Xiang GU Yihang ZHAO Shuai XU Erhui WANG Dong GUO Yuejiang SHI Huasheng XIE Yunfeng LIANG Minsheng LIU the EHL-2 Team 
the auspices of National Natural Science Foundations of China(Nos.12075284 and 12205157);supported by the High-End Talents Program of Hebei Province,Innovative Approaches towards Development of Carbon-Free Clean Fusion Energy(No.2021HBQZYCSB006).
The EHL-2 spherical torus is designed to demonstrate proton-boron(p-11B)fusion within a compact spherical tokamak.Its planned heating system includes a negative ion-based neutral beam injection(N-NBI),two positive ion...
关键词：H-MODE spherical torus(ST) EHL-2 PEDESTAL resonant magnetic perturbations 
Global stability of the plane wave solutions to the relativistic string equation with non-small perturbations
《Science China Mathematics》2025年第2期339-378,共40页Jinhua Wang Changhua Wei 
supported by National Natural Science Foundation of China(Grant Nos.12271450 and 11871408);supported by National Natural Science Foundation of China(Grant Nos.12071435 and 11871212);Zhejiang Provincial Outstanding Youth Science Foundation(Grant No.LR22A010004);the Fundamental Research Fund of Zhejiang Sci-Tech University。
This paper is concerned with the global stability of the plane wave solutions to the relativistic string equation with non-small perturbations.Under certain decay assumptions on the plane wave,we conclude that the per...
关键词：relativistic string plane wave null condition large energy global existence 
On-chip topological transport of integrated optical frequency combs
《Photonics Research》2025年第1期163-176,共14页ZHEN JIANG HONGWEI WANG PENG XIE YUECHEN YANG YANG SHEN BO JI YANGHE CHEN YONG ZHANG LU SUN ZHENG WANG CHUN JIANG YIKAI SU GUANGQIANG HE 
Key-Area Research and Development Program of Guangdong Province(2018B030325002);National Natural Science Foundation of China(62075129,61975119,62305210,62035016,62105200);Science and Technology on Metrology and Calibration Laboratory(JLKG2024001B002);SJTU Pinghu Institute of Intelligent Optoelectronics(2022SPIOE204).
Optical frequency combs in integrated photonics have widespread applications in high-dimensional optical computing,high-capacity communications,high-speed interconnects,and other paradigm-shifting technologies.However...
关键词：TOPOLOGICAL QUANTUM PERTURBATIONS 
Topological protection of optical skyrmions through complex media
《Light(Science & Applications)》2024年第12期3236-3252,共17页An Aloysius Wang Zimo Zhao Yifei Ma Yuxi Cai Runchen Zhang Xiaoyi Shang Yunqi Zhang Ji Qin Zhi-Kai Pong Tádé Marozsák Binguo Chen Honghui He Lin Luo Martin J.Booth Steve J.Elston Stephen M.Morris Chao He 
support of St John’s College,the University of Oxford,and the Royal Society(URF\R1\241734)(C.H.);the European Research Council(AdOMiS,no.695140)(C.H.and M.J.B.);Shenzhen Key Fundamental Research Project(No.JCYJ20210324120012035)(H.H.).
Optical Skyrmions have many important properties that make them ideal units for high-density data applications,including the ability to carry digital information through a discrete topological number and the independe...
关键词：TOPOLOGICAL PERTURBATIONS spatially 
A microfluidic coculture model for mapping signaling perturbations and precise drug screening against macrophage-mediated dynamic myocardial injury
《Acta Pharmaceutica Sinica B》2024年第12期5393-5406,共14页Zhao Gao Zhiyong Du Yu Hou Kun Hua Pengfei Tu Xiaoni Ai Yong Jiang 
supported by the National Natural Science Foundation of China(U23A20514,82174086,82173949, 82100295);the National Key Research and Development Project(2023YFC3505000,China);the Key Research and Development Project of Shandong Province(2021CXGC010507,China);the Beijing Natural Science Foundation(7222273,China).
Macrophage-mediated inflammation plays a pivotal role in cardiovascular disease pathogen-esis.However,current cell-based models lack a comprehensive understanding of crosstalk between mac-rophages and cardiomyocytes,h...
关键词：MICROFLUIDICS Heart-on-a-chip Macrophage-mediated inflammation Drug screening Metabolomics 
A Degenerate KAM Theorem for Partial Differential Equations with Unbounded Perturbations
《Acta Mathematica Sinica,English Series》2024年第11期2719-2734,共16页Mei Na GAO Jian Jun LIU 
supported by NNSFC(Grant No.11971299);supported by NNSFC(Grant Nos.12090010,12090013)。
In this paper,an infinite dimensional KAM theorem with unbounded perturbations and double normal frequencies is established under qualitative non-degenerate conditions.This is an extension of the degenerate KAM theore...
关键词：KAM theorem derivative nonlinear Schrödinger equation quasi-periodic solutions 
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