PHAGE_DISPLAY

作品数：80被引量：146H指数：7
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Biphenyl-dihydrothiazole-cyclized peptide libraries for peptide ligand and drug discovery
《Science China Chemistry》2025年第4期1434-1444,共11页Junjie Liu Xiangnan Sun Jie Zhuang Ziyan Liu Chaoying Xu Dalei Wu Chuanliu Wu 
the financial support from the National Natural Science Foundation of China(22174119 and 21974115);the Fundamental Research Funds for the Central Universities(20720210001 and 20720220005);the Program for Changjiang Scholars and Innovative Research Team in University(IRT_17R66);the Foundation for Innovative Research Groups of the National Natural Science Foundation of China(21521004)to C.Wu;the University Innovation Group Program of Jinan(202228080);the Shandong Provincial Natural Science Foundation(ZR2021JQ30);the Taishan Scholar Program of Shandong Province(tsqn201909004)to D.Wu.
Utilizing diverse organic crosslinkers for cyclization has proven to be an effective approach to creating peptide libraries;enabling the rapid discovery of functional peptides.Existing crosslinkers usually provide a t...
关键词：PEPTIDE phage display protein interaction cyclic peptide fluorescence 
Identification of LRG1 targeting peptide and its application in targeted imaging for breast cancer
《Nano Research》2024年第10期9044-9051,共8页Mengdie Chen Anying Zhu Furong Zhu Ziwen Lei Tao Huang Shengnan Du Dongdong Wang Xiaoyu Zhang Huan Min Yingqiu Qi Guangjun Nie 
supported by grants from the National Natural Science Foundation of China(Nos.32000998 and 32201240);The Young Elite Scientists Sponsorship Program by Henan Association for Science and Technology(No.2022HYTP046);the China Postdoctoral Science Foundation(No.2021TQ0298);Science and Technology Development Project of Henan Province(Nos.222102310525,232102310351);National College Students’innovation and entrepreneurship training program(No.202310459197).
Breast cancer remains a leading cause of morbidity and mortality among women worldwide,emphasizing the urgent need for enhanced diagnostic and therapeutic approaches.Leucine-rich-alpha-2-glycoprotein 1(LRG1)has emerge...
关键词：breast cancer leucine-rich-alpha-2-glycoprotein 1(LRG1) phage display PEPTIDE tumor targeting 
Encoding and display technologies for combinatorial libraries in drug discovery:The coming of age from biology to therapy
《Acta Pharmaceutica Sinica B》2024年第8期3362-3384,共23页Yu Fan Ruibing Feng Xinya Zhang Zhen-Liang Wang Feng Xiong Shuihua Zhang Zhang-Feng Zhong Hua Yu Qing-Wen Zhang Zhang Zhang Yitao Wang Guodong Li 
supported by the National Natural Science Foundation of China(82304698 and 32300317);Science and Technology Development Fund,Macao SAR(file nos.0048/2023/ITP2,0150/2022/A3,001/2023/ALC,0006/2020/AKP and 005/2023/SKL,China);Guangdong Basic and Applied Basic Research Foundation(grant nos 2021A1515110338,China);Natural Science Foundation of Guangdong Province(2024A1515012659 and 2023B1515120023,China);Shenzhen-Hong Kong-Macao S&T Program(Category C)(SGDX2020110309420200,China);the Research Fund of University of Macao(CPG2024-00038-ICMS,China).
Drug discovery is a sophisticated process that incorporates scientific innovations and cuttingedge technologies.Compared to traditional bioactivity-based screening methods,encoding and display technologies for combina...
关键词：Drug screening Phage display DNA-encoded chemical libraries Peptide-encoded chemical libraries Clinical drugs 
Identification and optimization of peptide inhibitors to block VISTA/PSGL-1 interaction for cancer immunotherapy被引量：2
《Acta Pharmaceutica Sinica B》2023年第11期4511-4522,共12页Xiaoshuang Niu Menghan Wu Guodong Li Xiuman Zhou Wenpeng Cao Wenjie Zhai Aijun Wu Xiaowen Zhou Shengzhe Jin Guanyu Chen Yanying Li Jiangfeng Du Yahong Wu Lu Qiu Wenshan Zhao Yanfeng Gao 
supported by grants from the National Natural Science Foundation of China (U1904147,U20A20369);Shenzhen Science and Technology Program (KQTD20190929173853397,China);“Pearl River Talent Plan”Innovation and Entrepreneurship Team Project of Guangdong Province (2019ZT08Y464,China)。
Developing new therapeutic agents for cancer immunotherapy is highly demanding due to the low response ratio of PD-1/PD-L1 blockade in cancer patients.Here,we discovered that the novel immune checkpoint VISTA is highl...
关键词：Immune checkpoint VISTA PSGL-1 Phage displayed biopanning PEPTIDE Cancer immunotherapy MDSC T cell 
Identification and epitope mapping of anti-p72 single-chain antibody against African swine fever virus based on phage display antibody library被引量：1
《Journal of Integrative Agriculture》2023年第9期2834-2847,共14页SONG Jin-xing WANG Meng-xiang ZHANG Yi-xuan WAN Bo DU Yong-kun ZHUANG Guo-qing LI Zi-bin QIAO Song-lin GENG Rui WU Ya-nan ZHANG Gai-ping 
supported by the National Natural Science Foundation of China(31941001 and 32002292);the Major Science and Technology Project of Henan Province,China(221100110600);the Natural Science Foundation of Henan Province(202300410199).
African swine fever virus(ASFV)is a lethal pathogen that causes severe threats to the global swine industry and it has already had catastrophic socio-economic effects.To date,no licensed prophylactic vaccine exists.Li...
关键词：ASFV phage display antibody library single chain antibody p72 EPITOPE 
Enhancement of T cell infiltration via tumor-targeted Th9 cell delivery improves the efficacy of antitumor immunotherapy of solid tumors
《Bioactive Materials》2023年第5期508-523,共16页Tao Chen Yucheng Xue Shengdong Wang Jinwei Lu Hao Zhou Wenkan Zhang Zhiyi Zhou Binghao Li Yong Li Zenan Wang Changwei Li Yinwang Eloy Hangxiang Sun Yihang Shen Mohamed Diaty Diarra Chang Ge Xupeng Chai Haochen Mou Peng Lin Xiaohua Yu Zhaoming Ye 
This work was supported by National Natural Science Foundation of China(81872173,82072959,31870959,and 82102855);Zhejiang Province Natural Science Foundation(LY20H160018,LD21H160002,and LY19H160045).
Insufficient infiltration of T cells severely compromises the antitumor efficacy of adoptive cell therapy(ACT)against solid tumors.Here,we present a facile immune cell surface engineering strategy aiming to substantia...
关键词：Adoptive cell therapy(ACT) Phage display Cell surface engineering Th9 cell Solid tumor 
High-throughput screening and biological display technology:Applications in molecular imaging
《iRADIOLOGY》2023年第1期18-35,共18页Renli Luo Hongguang Liu Zhen Cheng 
Key Laboratory of Bioresource Research and Development of Liaoning Province,Grant/Award Number:2022JH13/10200026;National Natural Science Foundation of China,Grant/Award Number:U2267221。
Molecular imaging plays important roles in many fields,including disease diagnosis,therapeutic efficacy evaluation,intraoperative imaging guidance,drug metabolism monitoring,and patient selection for appropriate treat...
关键词：molecular imaging high-throughput screening ligand selection phage display yeast display ribosome display mRNA display 
Identification and characterization of blocking nanobodies against human CD70
《Acta Biochimica et Biophysica Sinica》2022年第10期1518-1527,共10页Xin Zhang Chang Liu Yuan Xie Qianqian Hu Yuanyuan Chen Jiangwei Li 
supported by the grant from the National Natural Science Foundation of China(No.31570935/C081001).
CD70 is overexpressed in a variety of solid and hematological tumors and plays a role in tumor proliferation and evasion of immune surveillance.Targeting and blocking its binding to the receptor CD27 have the potentia...
关键词：CD70 CD27 NANOBODY phage display blocking antibody 
Screening of nanobody against Microcystis from a human phage display nanobody library被引量：1
《Journal of Oceanology and Limnology》2022年第5期1696-1705,共10页Yao ZU Wenjie MIAO Yu LUO Chen XU Qianhui PAN Siyu CHEN Jianhong LI 
Supported by the National Natural Science Foundation of China(Nos.31971561,31370217,31701724);the Research Program of Jiangsu Province of China。
Microcystis species identification is essential for ecological studies and water bloom control.Immunoassays are more specific and convenient and several approaches have been used to develop for diagnosing harmful red ...
关键词：control utilized identification 
Improving antibody affinity through in vitro mutagenesis in complementarity determining regions
《The Journal of Biomedical Research》2022年第3期155-166,共12页Wei Ye Xiaoyu Liu Ruiting He Liming Gou Ming Lu Gang Yang Jiaqi Wen Xufei Wang Fang Liu Sujuan Ma Weifeng Qian Shaochang Jia Tong Ding Luan Sun Wei Gao 
supported by the National Natural Science Foundation of China (Grant No. 81972284)
High-affinity antibodies are widely used in diagnostics and for the treatment of human diseases.However,most antibodies are isolated from semi-synthetic libraries by phage display and do not possess in vivo affinity m...
关键词：antibody engineering phage display affinity maturation 
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