PROTEIN-PROTEIN_INTERACTIONS

作品数:59被引量:141H指数:6
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相关作者:刘贤宇吕守芹毛利民郭鸣雷王任小更多>>
相关机构:中国科学院华中农业大学华中科技大学苏州大学更多>>
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  • 期刊=Neural Regeneration Researchx
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CNKSR2 interactome analysis indicates its association with the centrosome/microtubule system
《Neural Regeneration Research》2025年第8期2420-2432,共13页Lin Yin Yalan Xu Jie Mu Yu Leng Lei Ma Yu Zheng Ruizhi Li Yin Wang Peifeng Li Hai Zhu Dong Wang Jing Li 
supported by the National Nature Science Foundation of China,No.32101020(to JL);the Natural Science Foundation of Shandong Province,Nos.ZR2020MC071(to JL),ZR2023MH327(to HZ);the Integrated Project of Major Research Plan of National Natural Science Foundation of China,No.92249303(to PL);the Natural Science Foundation of Qingdao,No.23-2-1-193-zyyd-jch(to HZ)。
The protein connector enhancer of kinase suppressor of Ras 2(CNKSR2),present in both the postsynaptic density and cytoplasm of neurons,is a scaffolding protein with several protein-binding domains.Variants of the CNKS...
关键词:autism spectrum disorder CENTROSOME CNKSR2 intellectual disability INTERACTOME mass spectrometry MICROTUBULE neurodevelopmental disease protein complexes protein-protein interactions 
Spastin and alsin protein interactome analyses begin to reveal key canonical pathways and suggest novel druggable targets
《Neural Regeneration Research》2025年第3期725-739,共15页Benjamin R.Helmold Angela Ahrens Zachary Fitzgerald P.Hande Ozdinler 
funded by NIH-NIA R01AG061708 (to PHO);Patrick Grange Memorial Foundation (to PHO);A Long Swim (to PHO);CureSPG4 Foundation (to PHO)。
Developing effective and long-term treatment strategies for rare and complex neurodegenerative diseases is challenging. One of the major roadblocks is the extensive heterogeneity among patients. This hinders understan...
关键词:ALS2 alsin amyotrophic lateral sclerosis hereditary spastic paraplegia neurodegenerative diseases personalized medicine precision medicine protein interactome protein-protein interactions SPAST SPASTIN 
Modeling protein-protein interactions in axon initial segment to understand their potential impact on action potential initiation
《Neural Regeneration Research》2021年第4期700-706,共7页Piyush Bhardwaj Don Kulasiri Sandhya Samarasinghe 
The axon initial segment(AIS)region is crucial for action potential initiation due to the presence of high-density AIS protein voltage-gated sodium channels(Nav).Nav channels comprise several serine residues responsib...
关键词:Alzheimer’s disease ANKYRIN-G axon initial segment casein kinase-2 MICROTUBULES voltage-gated potassium channel voltage-gated sodium channel 
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