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作品数：165被引量：208H指数：7
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  • 期刊=Signal Transduction and Targeted Therapyx
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Intact regulation of G1/S transition renders esophageal squamous cell carcinoma sensitive to PI3Kαinhibitors
《Signal Transduction and Targeted Therapy》2023年第5期2315-2328,共14页Xu Zhang Yuxiang Wang Xi Zhang Yanyan Shen Kang Yang Qingyang Ma Yuemei Qiao Jiajie Shi Yi Wang Lan Xu Biyu Yang Gaoxiang Ge Landian Hu Xiangyin Kong Chunhao Yang Yi Chen Jian Ding Linghua Meng 
supported by the Lingang Laboratory (LG202103-02-03);National Natural Science Foundation of China (82173832,81973345 and 82104199);the State Key Laboratory of Drug Research (SIMM2205KF-05);Science and Technology Commission of Shanghai Municipality (22ZR1474400);“Personalized Medicines-Molecular Signature-based Drug Discovery and Development”,Strategic Priority Research Program of the Chinese Academy of Sciences (XDA12020111).
Phosphatidylinositol 3-kinase alpha(PI3Kα)inhibitors are currently evaluated for the therapy of esophageal squamous cell carcinoma(ESCC).It is of great importance to identify potential biomarkers to predict or monito...
关键词：ESOPHAGEAL SQUAMOUS RENDER 
Stellettin B renders glioblastoma vulnerable to poly (ADPribose) polymerase inhibitors via suppressing homologydirected repair被引量：1
《Signal Transduction and Targeted Therapy》2023年第4期1388-1391,共4页Xin Peng Yingying Wang Shaolu Zhang Zhennan Tao Yuxiang Dai Francois X.Claret Moshe Elkabets Hou-Wen Lin Zhe-Sheng Chen Dexin Kong 
the National Natural Science Foundation of China(82073890,81673464,and 82061148017,to DK,22137006 and 82104054,to HW L);Fellowship of China Postdoctoral Science Foundation(2021M702464 to XP);Postgraduate Innovation Fund of 13th Five-Year comprehensive investment of Tianjin Medical University(YJSCX201806 to XP).SF295 cell line was kindly provided by the National Cancer Institute,National Institutes of Health,USA.We thank Dr.Xi Chen from Tianjin Key Laboratory of Ophthalmology and Visual Science,Tianjin Eye Institute,Tianjin Eye Hospital for assistance in spectrometry proteomics data analysis.
Dear Editor,Glioblastoma(GBM)is one of the most fatal brain tumors.Current first-line post-surgery regimens for GBM including radiotherapy and temozolomide(TMZ)chemotherapy show very limited efficacy.1,2 Novel therape...
关键词：CHEMOTHERAPY SURGERY RENDER 
Development of a ferritin-based nanoparticle vaccine against the SARS-CoV-2 Omicron variant被引量：5
《Signal Transduction and Targeted Therapy》2022年第7期2135-2137,共3页Wanbo Tai Benjie Chai Shengyong Feng Xinyu Zhuang Jun Ma Mujia Pang Lin Pan Zi Yang Mingyao Tian Gong Cheng 
supported by the Emergency Key Program of Guangzhou Laboratory(EKPG21-33);the National Natural Science Foundation of China(32188101,32100755,81730063,81961160737 and 31825001);the National Key Research and Development Plan of China(2021YFC2300200,2020YFC1200104 and 2017ZX10304402).
Dear Editor,The COVID-19 pandemic has had a devastating effect on global health,resulting in over 6.2 million deaths worldwide.Continuous emergence of adaptive mutations of SARS-CoV-2 alters its pathogenicity and tran...
关键词：RENDER resistance initially 
Pancreatic cancer cells render tumor-associated macrophages metabolically reprogrammed by a GARP and DNA methylation-mediated mechanism被引量：5
《Signal Transduction and Targeted Therapy》2021年第11期3348-3365,共18页Mengwen Zhang Xingyi Pan Kenji Fujiwara Noelle Jurcak Stephen Muth Jiaojiao Zhou Qian Xiao Anqi Li Xu Che Zihai Li Lei Zheng 
L.Z.was supported by NIH grant R01 CA169702;NIH grant R01 CA197296;the Viragh Foundation and the Skip Viragh Pancreatic Cancer Center at Johns Hopkins,Sidney Kimmel Comprehensive Cancer Center Grant P30 CA006973;K.F.was supported by a JSPS Overseas Research Fellowship from the Japan Society for the Promotion of Science.Z.L.is supported by multiple NIH grants(R01 AI077283,P01 CA186866,R01 CA199419,and R01 CA213290).
How tumor-associated macrophages transit from a predominant antitumor M1-like phenotype to a protumoral M2-like phenotype during the development of pancreatic ductal adenocarcinoma (PDA) remains to be elucidated. We t...
关键词：METABOLISM METASTASIS MEDIATED 
The impact of receptor-binding domain natural mutations on antibody recognition of SARS-CoV-2被引量：2
《Signal Transduction and Targeted Therapy》2021年第4期1116-1118,共3页Cheng Li Xiaolong Tian Xiaodong Jia Jinkai Wan Lu Lu Shibo Jiang Fei Lan Yinying Lu Yanling Wu Tianlei Ying 
This work was supported by grants from the National Key R&D Program of China(2019YFA0904400);National Natural Science Foundation of China(81822027,81630090);National Megaprojects of China for Major Infectious Diseases(2018ZX10301403,2018ZX10101003);the staff from Core Facility of Microbiology and Parasitology,Shanghai Medical College,Fudan University.
Dear Editor,The ongoing COVID-19 pandemic has resulted in over 25.0 million confirmed cases and over 840,000 deaths globally.As the third severe respiratory disease outbreak caused by the coronavirus,COVID-19 has led ...
关键词：IMMUNITY eventually RENDER 
Beyond just a tight fortress:contribution of stroma to epithelial-mesenchymal transition in pancreatic cancer被引量：4
《Signal Transduction and Targeted Therapy》2020年第1期328-339,共12页Ashenafi Bulle Kian-Huat Lim 
supported by NIH/NCI R37CA219697-01,WUSTL SPORE Career Enhancement Award grant(1P50CA196510-01A1),American Cancer Society(RSG-17-203-01-TBG),and Alvin J.Siteman Cancer Center Siteman Investment Program(supported by Barnard Trust and The Foundation for Barnes-Jewish Hospital).
Novel effective treatment is direly needed for patients with pancreatic ductal adenocarcinoma(PDAC).Therapeutics that target the driver mutations,especially the KRAS oncoprotein and its effector cascades,have been ine...
关键词：stroma transition RENDER 
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