REPAGLINIDE

作品数：22被引量：85H指数：7
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相关领域：医药卫生更多>>
相关作者：方福生李春霖张秋梅龚燕平郭连宇更多>>
相关机构：天津医科大学代谢病医院中国人民解放军总医院更多>>
相关期刊：《Science China(Life Sciences)》《Acta Pharmacologica Sinica》《Science China Chemistry》《中国科技期刊数据库 医药》更多>>
相关基金：国家自然科学基金国家重点基础研究发展计划国家高技术研究发展计划更多>>
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2型糖尿病运用瑞格列奈治疗的效果观察
《中国科技期刊数据库 医药》2021年第3期47-47,49,共2页蒋萍 
为了推进分级诊疗,逐步完善社区首诊、双向转诊、分级诊疗的服务模式,提供三师共管慢病精细化管理服务。在我们基层的社区医院,推行了家庭医生签约服务,实行了慢病管理对2型糖尿病运用瑞格列奈疗效观察。方法:家庭医生签约服务时,对入...
关键词：慢病管理 2型糖尿病 患者 REPAGLINIDE 治疗效果 
Interaction of repaglinide with bovine serum albumin:Spectroscopic and molecular docking approaches被引量：2
《Journal of Pharmaceutical Analysis》2019年第4期274-283,共10页Suma K.Pawar Seetharamappa Jaldappagari 
the University Grants Commission,New Delhi,for providing the financial support to carry out this work [F.No 43-205/2014(SR)dated 18-08-2015];the University Grants Commission,New Delhi,for awarding the Rajiv Gandhi National Fellowship(F1-17.1/ 2016-17/RGNF-2015-17-SC-KAR-11858 dated January 2016)
Repaglinide (RPG) regulates the amount of glucose by stimulating the pancreas to release insulin in the blood. In view of its biological importance, we have examined the interaction between RPG and a model protein, bo...
关键词：BSA-RPG INTERACTION SPECTROSCOPIC investigation Molecular DOCKING 
Study on the interactions of pharmacokinetics and liver distributions between rosuvastatin and repaglinide in rats被引量：1
《Journal of Chinese Pharmaceutical Sciences》2018年第1期22-30,共9页Dujuan Zhang Keguang Chen Rui Zhang Guiyan Yuan Benjie Wang Ruichen Guo 
In the present study,we aimed to investigate the interactions of pharmacokinetics and liver distributions between rosuvastatin and repaglinide in rats.Coadministration of repaglinide（0.5 mg/kg,1 mg/kg and 2 mg/kg） f...
关键词：ROSUVASTATIN REPAGLINIDE PHARMACOKINETICS Drug-drug interaction Liver distribution 
Derivative Spectrophotometric and Isocratic High Performance Liquid Chromatographic Methods for Simultaneous Determination of Repaglinide and Metformin Hydrochloride in Pharmaceutical Preparations
《American Journal of Analytical Chemistry》2017年第9期541-552,共12页Serap Saglik Aslan Berna Yilmaz 
supported by Scientific Research Projects Coordination Unit of Istanbul University,Project number:12275.
In this study, a derivative spectrophotometric method and one HPLC method were developed and validated for analysis of anti-diabetic drugs, repaglinide (RPG) and metformine hydrochloride (MTF) in tablets. The spectrop...
关键词：REPAGLINIDE METFORMIN Derivative Spectrophotometry HPLC Drug Analysis 
Efficacy and safety of metformin and sitagliptin based triple antihyperglycemic therapy(STRATEGY):a multicenter,randomized,controlled,non-inferiority clinical trial被引量：20
《Science China(Life Sciences)》2017年第3期225-238,共14页Wen Xu Yiming Mu Jiajun Zhao Dalong Zhu Qiuhe Ji Zhiguang Zhou Bin Yao Anhua Mao Samuel S.Engel Bin Zhao Yan Bi Longyi Zeng Xingwu Ran Juming Lu Linong Ji Wenying Yang Weiping Jia Jianping Weng 
supported by Merck&Co.,Inc.,Kenilworth,NJ,the 5010 Project of Sun Yat-sen University;Program for Changjiang Scholars and Innovative Research Team in University(to Jianping Weng)
Despite the current guideline's recommendation of a timely stepwise intensification therapy,the "clinical inertia",termed as the delayed treatment intensification,commonly exists in the real world,which may be partly ...
关键词：type 2 diabetes oral antihyperglycemic agent metformin DPP-4 inhibitor glimepiride gliclazide repaglinide acarbose 
Simultaneous determination of Repaglinide and Irbesartan in biological plasmas using micellar enhanced excitation-emission matrix fluorescence coupled with ATLD method被引量：1
《Science China Chemistry》2016年第7期816-823,共8页Haiyan Fu Hedong Li Mei Shao Tianming Yang Xu Zhang Rujing Xu Yujuan Wei Shuhua Chen Chuang Ni Hailong Wu 
supported by the National Natural Science Foundation of China (21205145, 21575039);the Open Funds of State Key Laboratory of Chemo/Biosensing and Chemometrics of Hunan University (201111);The Open Research Program (2015ZD001, 2015ZD002) from the Modernization Engineering Technology Research Center of Ethnic Minority Medicine of Hubei province
A highly sensitive and selective 3D excitation-emission fluorescence method has been proposed to rapidly quantify the combined antidiabetics Repaglinide(Re) and Irbesartan(Ir) in rat and human plasmas with the aid of ...
关键词：REPAGLINIDE IRBESARTAN micellar enhanced fluorescence alternating trilinear decomposition 
<i>In Vitro</i>and <i>in Vivo</i>(Mouse) Evaluation of Drug-Drug Interactions of Repaglinide with Anti-HIV Drugs被引量：1
《Pharmacology & Pharmacy》2015年第4期241-246,共6页Vijay Saradhi Mettu P. Yadagiri Swami P. Abigna A. Ravinder Nath Geeta Sharma 
Repaglinide is type 2 short acting anti-diabetic drug which is primarily metabolized by CYP2C8 and CYP3A4 and is also a substrate of influx transporter OATP1B1. HIV drugs are potent inhibitors of CYP3A4 and OATP trans...
关键词：REPAGLINIDE Drug-Drug Interaction REPAGLINIDE Km REPAGLINIDE BIOANALYTICAL Method 
A simple method to improve the dissolution of repaglinide and exploration of its mechanism被引量：1
《Asian Journal of Pharmaceutical Sciences》2014年第4期218-225,共8页Zhaolu Zhu Tianzhi Yang Yanan Zhao Nannan Gao Donglei Leng Pingtian Ding 
The work was supported by Shenyang Pharmaceutical University(10163),including the financial support.
In the present study,a simple and rapid method was developed to improve the in vitro dissolution of repaglinide,an oral antidiabetic drug,which was based on addition of meglumine in 50%(v/v)ethanol to dissolve repagli...
关键词：In vitro dissolution REPAGLINIDE MEGLUMINE SOLUBILIZATION Molecular complex 
Liquid Chromatography Tandem Mass Spectrometry Method for Determination of Anti-Diabetic Drug Repaglinide in Human Plasma被引量：1
《American Journal of Analytical Chemistry》2014年第4期281-290,共10页Manar K. Fayyad Ezzeldeen H. Ghanem 
A highly sensitive, accurate and rapid analytical method based on reversed-phase liquid chromatography/electrospray ionization tandem mass spectrometry (RP-LC-ESI-MS/MS) has been developed and validated for the determ...
关键词：REPAGLINIDE LC-MS/MS Human PLASMA BIOEQUIVALENCE 
Pharmacokinetic study of repaglinide floating drug delivery system in rabbits by RP-HPLC method被引量：1
《Journal of Chinese Pharmaceutical Sciences》2012年第2期162-168,共7页T.Ramanjireddy D.Dhachinamoorthi K.B.Chandrasekhar 
The present work is aimed to study the pharmacokinetic parameters of optimized repaglinide floating drug delivery system(FDDS) by 24 factorial designs,followed by comparison with a commercially available formulation.T...
关键词：Pharmacokinetic study Floating drug delivery system Rabbit model 
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