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LSD1 is required for euchromatic origin firing and replication timing被引量：1
《Signal Transduction and Targeted Therapy》2022年第5期1703-1718,共16页Yue Wang Yunchao Huang Edith Cheng Xinhua Liu Yu Zhang Jianguo Yang Jordan T.F.Young Grant W.Brown Xiaohan Yang Yongfeng Shang 
This work was supported by grants(2021YFA1300603 to Y.S.and 2019YFA0508904 to J.L.)from the Ministry of Science and Technology of China;(82188102,81730079,and 31991164 to Y.S.and 31371372 and 81874154 to X.Y.)from the National Natural Science Foundation of China,and the Canadian Institutes of Health Research(MOP79368 and FDN-159913 to G.W.B.).We thank Tina L.Sing,David Gallo,and Brandon Ho of the Brown lab for assistance with flow cytometry analysis and with DNA fiber assays.
The chromatin-based rule governing the selection and activation of replication origins remains to be elucidated.It is believed that DNA replication initiates from open chromatin domains;thus,replication origins reside...
关键词：ORIGIN LSD1 REPLICATION 
Cyclin A2/cyclin-dependent kinase 1-dependent phosphorylation of Top2a is required for S phase entry during retinal development in zebrafish被引量：1
《Journal of Genetics and Genomics》2021年第1期63-74,共12页Miaomiao Jin Jingyu Li Ruikun Hu Baijie Xu Guanliang Huang Weilai Huang Bo Chen Jie He Ying Cao 
supported by grants from the National Key Research and Development Program of China (2017YFA0104600);the National Natural Science Foundation of China (31970767, 31771597 and 31571515);the National Basic Research Program of China (973 Program 2012CB966601 and 2013CB945300);the Ministry of Science and Technology of the People’s Republic of China (2011DFB30010)。
Cyclin-dependent kinase 1 (CDK1) plays an essential role in cell cycle regulation.However,as mouse Cdk1embryos die early,the role of CDK1 in regulating the cell cycle and embryo development remains unclear.Here,we sho...
关键词：CDK1 Cyclin A2 Cyclin B1 Top2a M phase S phase entry IKNM 
Three paternally imprinted regions are sequentially required in prenatal and postnatal mouse development
《Science China(Life Sciences)》2020年第1期165-168,共4页Max Jiahua Li Xiajun Li 
supported by the grant from Ministry of Science and Technology of China(2018YFC1005004 to XL);Science and Technology Commission of Shanghai Municipality(18PJ1407700 to XL)
Reproduction in mammals is primarily through fertilization of the oocytes and sperms generated by the females and males,respectively.Fusion of two haploid genomes leads to formation of the diploid zygotes,which sequen...
关键词：sequentially IMPLANTATION primarily 
Taurine Transporter dEAAT2 is Required for Auditory Transduction in Drosophila被引量：4
《Neuroscience Bulletin》2018年第6期939-950,共12页Ying Sun Yanyan Jia Yifeng Guo Fangyi Chen Zhiqiang Yan 
supported by funds from The Ministry of Science and Technology of China (2017YFA0103900 and 2016YFA0502800);The National Natural Science Foundation of China (31571083);supported by The National Natural Science Foundation of China (81470701);The National Natural Science Foundation of China (81771882);The Program for Professor of Special Appointment (Eastern Scholar of Shanghai; TP2014008);The Shanghai Rising-Star Program (14QA1400800);a grant from the Young 1000 Talent Program of China to ZY;The Fundamental Research (Discipline Layout) Foundation from Shenzhen Committee of Science, Technology and Innovation (JCYJ20170817111912585) to FC
Drosophila dEAAT2, a member of the excitatory amino-acid transporter(EAAT) family, has been described as mediating the high-affinity transport of taurine, which is a free amino-acid abundant in both insects and mammal...
关键词：Drosophila dEAAT2 TAURINE Chordotonal neurons Sound transduction 
Acetylglutamate kinase is required for both gametophyte function and embryo development in Arabidopsis thaliana被引量：4
《Journal of Integrative Plant Biology》2017年第9期642-656,共15页Jie Huang Dan Chen Hailong Yan Fei Xie Ying Yu Liyao Zhang Mengxiang Sun Xiongbo Peng 
supported by the Fund of Key Basic Theory Research of Ministry of Science and Technology of China(2013CB945100);the National Natural Science Foundation of China(31570317,31270362)
The specific functions of the genes encoding arginine biosynthesis enzymes in plants are not well characterized. We report the isolation and characterization of Arabidopsis thaliana N-acetylglutamate kinase （NAGK）, ...
关键词：Acetylglutamate kinase is required for both gametophyte function and embryo development in Arabidopsis thaliana Figure 
Interferon-related secretome from direct interaction between immune cells and tumor cells is required for upregulation of PD-L1 in tumor cells
《Protein & Cell》2016年第7期538-543,共6页Yuan-Qin Yang Wen-Jie Dong Xiao-Fei Yin Yan-Ni XU Yu Yang Jiao-Jiao Wang Su-Jing Yuan Jing Xiao Jonathan Howard DeLong Liang Chu Hai-Neng Xu Xiu- Mei Zhou Ru-Wei Wang Ling Fang Xin-Yuan Liu Kang-Jian Zhang 
Dear Editor, PD-L1, also known as CD274, plays a vital role in tumor cell related immune escape. It can be expressed on the cell surface of many solid tumors （Brahmer et al., 2012） and inhibits T cell proliferation ...
ERK1/2 Activities Are Dispensable for Oocyte Growth but Are Required for Meiotic Maturation and Pronuclear Formation in Mouse被引量：4
《Journal of Genetics and Genomics》2015年第9期477-485,共9页Yin-Li Zhang Xiao-Man Liu Shu-Yan Ji Qian-Qian Sha Jue Zhang Heng-Yu Fan 
supported by the National Basic Research Program of China (Nos. 2011CB944504 and 2012CB944403);the National Natural Science Foundation of China (Nos. 81172473 and 31371449)
Previous studies revealed that extracellular regulated kinase-1 and -2 （ERK1/2） cascade plays pivotal roles in regulating oocyte meiotic cell cycle progression. However, most knowledge about the in vivo function of ...
关键词：OOCYTE Female reproduction MEIOSIS ERK1/2 FERTILIZATION 
ADAR1 is required for differentiation and neural induction by regulating microRNA processing in a catalytically independent manner被引量：10
《Cell Research》2015年第4期459-476,共18页Tian Chen Jian-Feng Xiang Shanshan Zhu Siye Chen Qing-Fei Yin Xiao-Ou Zhang Jun Zhang Hua Feng Rui Dong Xue-Jun Li Li Yang Ling-Ling Chen 
We are grateful to G Carmichael for critical reading of the manuscript, and all the lab members for helpful discussion. H9 cells were obtained from the WiCell Research Institute. This work was supported by the Ministry of Science and Technology of China （2014CB964802 and 2011CBA01105）, Chinese Academy of Sciences （XDA01010206）, the National Natural Science Foundation of China （91440202, 31271390, 31322018 and 31271376）.
Adenosine deaminases acting on RNA （ADARs） are involved in adenosine-to-inosine RNA editing and are implicated in development and diseases. Here we observed that ADAR1 deficiency in human embryonic stem cells （hESC...
关键词：ADAR1 RNA editing embryonic stem cell neural induction MIRNA 
RAGl-mediated ubiquitylation of histone H3 is required for chromosomal V（D）J recombination
《Cell Research》2015年第2期181-192,共12页Zimu Deng Haifeng Liu Xiaolong Liu 
Acknowledgments We thank Drs David G Schatz, David Roth, Stephen Desiderio and Martin Gellert for providing recombination plasmids. We are grateful to our colleagues H Chen for animal husbandry and W Bian for cell sorting. This work was supported by grants from National Basic Research Program of China （2013CB835300 and 2012CB518700）, National Natural Science Foundation of China （31270936 and 81261120380） and Shanghai Municipal Government （12XD 1405800）.
RAG1 and RAG2 proteins are key components in V（D）J recombination. The core region of RAG1 is capable of catalyzing the recombination reaction; however, the biological function of non-core RAG1 remains largely unknow...
关键词：RAG 1 UBIQUITYLATION V（D）J recombination histone H3 
Response of Soil Phosphorus Required for Maximum Growth of Asparagus officinalis L. to Inoculation of Arbuscular Mycorrhizal Fungi被引量：8
《Pedosphere》2014年第6期776-782,共7页XU Ping LIANG Lin-Zhou DONG Xiao-Ying XU Jing JIANG Pei-Kun SHEN Ren-Fang 
Supported by the National Key Basic Research Program(No.2013CB127401);the Strategic Priority Research Program of Chinese Academy of Science(No.XDB15030300);the National Natural Science Foundation of China(Nos.41001172 and 41371289)
Fertilizer application efficiently increases crop yield, but may result in phosphorus(P) accumulation in soil, which increases the risk of aquatic eutrophication. Arbuscular mycorrhizal fungi(AMF) inoculation is a pot...
关键词：ASPARAGUS mycorrhizal dependence phosphorus-utilization efficiency root colonization spore density 
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