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SIGNAL_TRANSDUCTION: 作品数：482被引量：3037H指数：28; 导出分析报告; 相关作者：张春翌沈万华袁莉张光毅陈伟更多>>; 相关机构：徐州医学院中国农业大学华中科技大学上海中医药大学更多>>; 相关期刊：更多>>; 相关基金：国家自然科学基金国家重点基础研究发展计划中国博士后科学基金国家高技术研究发展计划更多>>

Pancreatic ductal adenocarcinoma chemoresistance:From metabolism reprogramming to novel treatment被引量：1: 《Chinese Medical Journal》2024年第4期408-420,共13页Jingcheng Zhang Yutong Wang Lejunzi Wang Lei You Taiping Zhang; supported by grants from the National Natural Science Foundation of China(Nos.81772639 and 81802475);Natural Science Foundation of Beijing(No.7192157); As pancreatic cancer(PC)is highly malignant,its patients tend to develop metastasis at an early stage and show a poor response to conventional chemotherapies.First-line chemotherapies for PC,according to current guide...; 关键词：Pancreatic cancer Drug resistance Drug development Signal transduction

Protein kinases in cardiovascular diseases: 《Chinese Medical Journal》2022年第5期557-570,共14页Jiawen Chen Yafei Li Chong Du Tianwen Wei Tiankai Shan Liansheng Wang; National Natural Science Foundation of China (Nos. 81770361& 82070367)。; Cardiovascular disease(CVD)remains the leading cause of death worldwide.Therefore,exploring the mechanism of CVDs and critical regulatory factors is of great significance for promoting heart repair,reversing cardiac r...; 关键词：Protein kinases Signal transduction Cardiovascular diseases PHOSPHORYLATION

Immune Regulation of Interleukin-27 in Malignant Pleural Effusion被引量：4: 《Chinese Medical Journal》2015年第14期1932-1941,共10页Shi Li Wen-Jie You Jian-Chu Zhang Qiong Zhou Huan-Zhong Shi; Source of Support： This work was supported by grants in part from National Basic Research Program of China （No. 2012CB518706）; in part from National Natural Science Foundation of China （No. 81272591 and No. 81470274）. Conflict of Interest： None declared.; Background： lnterlcukin （IL）-27 has been reported to have anti-proliferate and anti-angiogenic activities on cancer cells. However, the involvement of IL-27 in malignant pleural effusion （MPE） remains unknown. Th...; 关键词：INTERLEUKIN-27 Lung Cancer Malignant Pleural Effusion Signal Transduction

Urotensin Ⅱ promotes monocyte chemoattractant protein-1 expression in aortic adventitial fibroblasts of rat被引量：7: 《Chinese Medical Journal》2014年第10期1907-1912,共6页Zhang Yonggang Bao Shilin Kuang Zejian Ma Yanjun Hu Yanchao Mao Yanyan; This project was supported by grants from National Natural Science Foundation of China （No. 30971273 and No. 81270223） and Natural Science Foundation of Guangdong Province of China （No. 9151051501000016 and No. S2011010000450）.; Background Urotensin Ⅱ （Ull）,a potent vasoconstrictive peptide,is able to stimulate phenotypic differentiation of adventitial fibroblasts.This study aimed to determine the effect of UII on monocyte chemoattractant ...; 关键词：urotensin Ⅱ monocyte chemoattractant protein-1 adventitial fibroblasts signal transduction

A single nucleotide polymorphism in the human bone morphogenetic protein-2 gene （109T〉G） affects the Smad signaling pathway and the predisposition to ossification of the posterior longitudinal ligament of the spine被引量：8: 《Chinese Medical Journal》2013年第6期1112-1118,共7页YAN Liang CHANG Zhen LIU Yang LI Yi-bing HE Bao-rong HAO Ding-jun; This research was supported by a grant from the National Natural Science Foundation of China （No. 81071486）.Acknowledgments： The authors thank the DNA donors for making this study possible.; Background Although various systemic and local factors such as abnormal carbohydrate or calcium metabolism, aging, and hormonal disturbances have been suggested as causes of ossification of the posterior longitudinal ...; 关键词：ossification of the posterior longitudinal ligament single nucleotide polymorphisms bone morphogenetic protein-2 signal transduction

Recent advances and findings of angiotensin type 2 receptor：a review被引量：1: 《Chinese Medical Journal》2010年第23期3462-3466,共5页ZUO Yu-mei WANG Yuan LIU Jian-ping; Angiotensinogen is a member of the serpin family. It is produced constitutively and released into the circulation mainly by the liver. Angiotensinogen forms angiotensin Ⅰ by action of the circulated renin released fr...; 关键词：angiotensin type 2 receptor POLYMORPHISM signal transduction cardiovascular system OVEREXPRESSION

Modulating protein kinase D1 signal transduction: 《Chinese Medical Journal》2009年第15期1816-1820,共5页ZHANG Wei XU Jian JIA Chang-ku ZHENG Shu-sen; Protein kinase C （PKC） consists of a family of serine/threonine kinases that are identified by the presence of two copies of the C1 domain, which form the diacylglycerol （DAG）-binding module. According to their en...; 关键词：protein kinase D signal transduction APOPTOSIS SURVIVAL

The mechanism of signal transduction during vascular smooth muscle cell proliferation induced by autoantibodies against angiotensin AT1 receptor from hypertension被引量：18: 《Chinese Medical Journal》2008年第1期43-48,共6页SUN Yan-xiang ZHANG Hai-yan WEI Yu-miao ZHU Feng WANG Min LIAO Yu-hua; The first two authors contributed equally to this work. This study was supported by a grant from National Natural Science Foundation of China （No. G30300/33）.; Background Autoantibodies against angiotensin AT1 receptor have been discovered in patients with preeclampsia or malignant hypertension. Some studies have demonstrated that the autoantibodies are involved in the immun...; 关键词：AUTOANTIBODY angiotensin AT1 receptor proliferation Janus kinase-signal transduction activation of transcription nuclear factor-xB

Interaction of signal transduction between angiotensin AT_1 and AT_2 receptor subtypes in rat senescent heart被引量：1: 《Chinese Medical Journal》2007年第20期1820-1824,共5页SHI Shu-tian LI Yan-fang; Natural Science Foundation of Beijing(No.7042056); Background Angiotensin Ⅱ （Ang Ⅱ） acting at angiotensin AT1 receptor （AT1R） has well documented effects on cardiovascular structure such as the promotion of cardiovascular hypertrophy and fibrosis, which are beli...; 关键词：receptor angiotensin type 1 receptor angiotensin type 2 signal transduction INTERACTION

A therapeutic anti-CD4 monoclonal antibody inhibits T cell receptor signal transduction in mouse autoimmune cardiomyopathy被引量：2: 《Chinese Medical Journal》2007年第15期1319-1325,共7页WANG Zhao-hui LIAO Yu-hua YUAN Jing ZHANG Li WANG Min ZHANG Jing-hui LIU Zhong-ping DONG Ji-hua; a grant from the National Natural Science Foundation of China(No.30000070); Background T cell immune abnormalities in patients with dilated cardiomyopathy （DCM） has been intensively studied over the past 10 years. Our previous study has suggested that immunization of mice with the peptides ...; 关键词：adenine nucleotide translocator CD4 signal transduction CYTOKINE CARDIOMYOPATHY

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