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  • 期刊=Journal of Traditional Chinese Medicinex
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Network pharmacology-based study on the mechanism of Tangfukang formula(糖复康方) against type 2 diabetes mellitus
《Journal of Traditional Chinese Medicine》2025年第1期76-88,共13页YAN Kai WANG Wei WANG Yan GAO Huijuan FENG Xingzhong 
Tsinghua Precision Medicine Foundation:Tangfukang Plays the Therapeutic Role in Type 2 Diabetes Patients with Qi and Yin Deficiency Syndrome by Regulating the Intestinal Flora Mediated Branched-chain Amino Acids-Phosphatidylinositide 3-Kinases-Protein Kinase B Signaling Pathway(grant number 10001020105);National Natural Science Foundation of China:Tangfukang Plays the Therapeutic Role in Type 2 Diabetes Mellitus by Regulating the Intestinal Flora Mediated Adiponectin-adenosine 5-Monophosphate-activated Protein Kinase-branched-chain Amino Acids Signaling Pathway(grant number 82104812)。
OBJECTIVE:To explore the mechanism of Tangfukang formula(糖复康方,TFK)in treating type 2 diabetes mellitus(T2DM).METHODS:We employed network pharmacology combined with experimental validation to explore the potential ...
关键词：network pharmacology diabetes mellitus type 2 AMP-activated protein kinase kinases signal transduction MECHANICS Tangfukang formula 
Moxibustion inhibits the macrophage M1 polarization toll-like receptor 4/myeloid differentiation factor 88/nuclear factor kappa B signaling pathway by regulating T-cell immunoglobulin and mucin-containing protein-3 in rheumatoid arthritis
《Journal of Traditional Chinese Medicine》2024年第6期1227-1235,共9页LUO Kun ZHONG Yumei GUO Yanding ZHANG Linlin HU Danhui MA Wenbin YANG Xin ZHOU Haiyan 
the National Natural Science Foundation of China:Study on Immunoregulatory Mechanism of Moxibustion"Regulating Weiqi"to Regulate the Intrasynovial Environment Steady State in Rheumatoid Arthritis Model Rats based on the Skin-resident Memory T cells-Growth Arrest-specific 6/Mer Tyrosine Kinase (No. 82374587);the National Natural Science Foundation of China:Study on the Immune Mechanisms of Macrophage M1/M2 Polarization in the Treatment of Rheumatoid Arthritis by Moxibustion"Strengthening Body Resistance and Eliminating Evil"(No. 81973959);the National Key R&D Program of China:Research on the Functional Characteristics of"Special Effects"and"Common Effects"of Acupoints (No. 2019YFC1709001);Science and Technology Innovation Seedling Project of Sichuan Province:based on Macrophage M1 Polarization Signaling Pathway Toll-like receptor 4/Myeloid differentiation factor 88/Nuclear factor kappa B and its Regulatory Molecule T-cell Immunoglobulin and Mucin-containing Protein-3 Exploring the Effect Mechanism of Moxibustion on Experimental Rheumatoid Arthritis Model (No. 2022037)。
OBJECTIVE: To explore whether moxibustion exerts therapeutic effects on rheumatoid arthritis(RA) by regulating the expression of T-cell immunoglobulin and mucin-containing protein-3(TIM-3) and subsequently modulating ...
关键词：MOXIBUSTION ARTHRITIS RHEUMATOID TIM-3 macrophage polarization toll-like receptor 4 myeloid differentiation factor 88 nuclear factor kappa B signal transduction 
Actinidia chinensis polysaccharide interferes with the epithelial-mesenchymal transition of gastric cancer by regulating the nuclear transcription factor-κB pathway to inhibit invasion and metastasis
《Journal of Traditional Chinese Medicine》2024年第5期896-905,共10页ZHANG Guangshun XU Xiaonan XU Chuyun LIAO Guanghui XU Hao LOU Zhaohuan ZHANG Guangji 
National Key Research and Development Program of Traditional Chinese Medicine Modernization Research Key Project:Innovative Research and Application based on the Core Etiology and Pathogenesis of Different Diseases and the Same Treatment Plan based on"Blood Stasis,Toxin and Depression"(2019YFC1708700,2019YFC1708701);National Natural Science Foundation of China Key Project:Biological Basic Research on Gastric Cancer-Carcinoma Transformation and Intervention by Removing Blood Stasis and Detoxification Based on the Pathogenesis Theory of Blood Stasis and Toxin Interaction(82030119);General project of the National Natural Science Foundation of China:Study on the Mechanism of Tanshinone Combined with Arsenic Trioxide Stasis and Poison to Regulate Macrophage Polarization and Improve the Inflammatory Microenvironment of Liver Cancer(81874455);Key R&D Program of Zhejiang Province:Research on Innovative Traditional Chinese Medicine Drugs-preclinical Research on Anti-lung Cancer of Diterpenoid Tanshinone(2019C03072);Zhejiang Province Traditional Chinese Medicine Modernization Project:Study on the Diagnosis and Treatment Program of Damp-heat Accumulation Type Colorectal Cancer Based on Correlation Analysis of Intestinal Microbiota-Traditional Chinese Medicine Syndrome Type(2020ZX005);Key Research Projects of Zhejiang Traditional Chinese Medicine Science and Technology Program:Research on Quantitative Characterization of Preparation Process and Quality Standard Control Specification of Traditional Chinese Medicine Paste(Gao Zi Ji)(2019ZZ006);National Natural Science Foundation of China General Project:Study on the Molecular Mechanism of Actinidia Chinensis Polysaccharide Interfering with Epithelial Mesenchymal Transformation in Gastric Cancer by Inhibiting Nuclear Factor-κB Pathway(81273904);The Research Project of Zhejiang Chinese Medical University:Study on the Mechanism of the Effective Components of Tengli Root Regulating Tumor-associated Fibroblasts to Improve the Tumor Microenvironment and Prevent the Metastasis of Ga
OBJECTIVE:To investigate the mechanisms of the effect of Actinidia chinensis polysaccharide(ACPS)on the invasion and metastasis of gastric cancer cells.METHODS:BGC-823-Luc gastric cancer cells stably transfected with ...
关键词：stomach neoplasms INVASION neoplasm metastasis epithelial-mesenchymal transition NF-kappa B signal transduction Actinidia chinensis polysaccharide 
Study on the anti-inflammatory mechanism of moxibustion in rheumatoid arthritis in rats based on phospholipaseA2 signaling inhibition by Annexin 1
《Journal of Traditional Chinese Medicine》2024年第4期753-761,共9页GUO Yanding LUO Kun ZHANG Linlin LU Wenting SHANG Yanan ZHONG Yumei HU Danhui YANG Xin ZHOU Haiyan 
Grants from the National Natural Science Foundation of China:Study on the Immune Mechanism of Macrophages 1/Macrophages 2 Polarization of Macrophages Treated with Moxibustion"Strengthening the Body and Expelling Pathogenic Qi"for"Struggle Between Healthy Qi and Pathogenic Qi"in Rheumatoid Arthritis(No.81973959);the National Key R&D Program of China:a Comparative Study of Moxibustion at Zusanli(ST36)on the Polarization of Knee Synovial Macrophage in Kneeosteoar-thritis and Rheumatoid Arthritis Rat Models(No.2019YFC1709001);the National Natural Science Foundation of China:Study on the Regulatory Mechanism of the"Immune-Inflammation"Molecular Signal of the Nucleotide—Binding Oligomerization Domain,Leucine rich Repeat and Pyrin domain containing Proteins 3 Inflammasome Treated by Moxibustion for Rheumatoid Arthritis(No.81774435);the Foundation of Chengdu University of Traditional Chinese Medicine:Study on the Mechanism of"Macrophage Migration Inhibitory Factor-Target Protein-Glucocorticoid-Inflammation"in Moxibustion Treatment and Anti-inflammatory Effect of Rheumatoid Arthritis(No.QNXZ2018034);the Science and Technology Innovation Seedling Project of Sichuan Province:Exploring the Effector Mechanism of Moxibustion Treatment in the Experimental Rheumatoid Arthritis Model based on the Macrophage Macrophages 1 Polarization Signaling Pathway Toll-like Receptors 4-Maximum Tolerated Dose 88-Nuclear Factor-Kappa B and its Regulatory Molecule T Cell Immunoglobulin and Mucin Domain-containing Protein 3(No.2022037)。
OBJECTIVE:To determine whether moxibustion had an anti-inflammatory effect on rheumatoid arthritis(RA)by regulating Annexin 1 expression and interfering with the phospholipaseA2 signaling pathway.METHODS:Thirty male S...
关键词：ANNEXINS group IV phospholipases A2 signal transduction MOXIBUSTION arthritis rheumatoid 
Emodin suppresses alkali burn-induced corneal inflammation and neovascularization by the vascular endothelial growth factor receptor 2 signaling pathway
《Journal of Traditional Chinese Medicine》2024年第2期268-276,共9页ZHENG Xueying GUO Liang LAI Siyi LI Fengyue LIANG Mingli LIU Wanting MENG Chun LIU Guanghui 
Fujian Major Research Grants for Young and Middle-aged Health Professionals(No.2021ZQNZD012,Research and Development of Anti-Keratitis Protein Drug Sgp130);National Natural Science Foundation of China(No.81774369,Study on Mechanism of Yijing Decoction in Preventing Microvascular Damage of Early Diabetic Retinopathy based on MMPs/TIMPs)。
OBJECTIVE:To investigate the effects of emodin on alkali burn-induced corneal inflammation and neovascularization.METHODS:The ability of emodin to target vascular endothelial growth factor receptor 2(VEGFR2)was predic...
关键词：alkali burn EMODIN corneal inflammation corneal neovascularisation vascular endothelial growth factor receptor-2 signal transduction 
Protective effect of modified Huangqi Chifeng decoction(加味黄芪赤风汤)on immunoglobulin A nephropathy through toll-like receptor 4/myeloid differentiation factor 88/nuclear factor-kappa B signaling pathway
《Journal of Traditional Chinese Medicine》2024年第2期324-333,共10页LI Liusheng ZHAO Mingming CHANG Meiying SI Yuan ZHAO Jinning YANG Bin ZHANG Yu 
Joint Innovation Fundation of JIICM:Health Management of Chronic Kidney Disease Based on Integrated Traditional Chinese And Western Medicine(No.2021IR009);Natural Science Foundation-funded Project:the Mechanism of Modified Huangqi Chifeng Decoction Protect Damaged Podocyte via Cross-Talking of PI3K/AKT/mTOR and AMPK/mTOR/ULK1 Signaling Pathway Regulate Autophapy(No.81873300);the Central Publicinterest Scientific Institution Basal Research Fund of the China Academy of Chinese Medical Sciences:Comprehensive Evaluation of Clinical efficacy of Modified Huangqi Chifeng Decoction on IgA Nephropathy(No.ZZ11-023);the Beijing Municipal of Science and Technology Major Project:Evaluation of Clinical Efficacy of Modified Huangqi Chifeng Decoction in Treating Proteinuria in IgA Nephropathy Based on"Deficiency-Wind-Blood-Stasis-Toxicity"Mechanism in Chinese Medicine(No.Z191100006619063)。
OBJECTIVE:To examine the nephroprotective mechanism of modified Huangqi Chifeng decoction(加味黄芪赤风汤,MHCD)in immunoglobulin A nephropathy(IgAN)rats.METHODS:To establish the IgAN rat model,the bovine serum albumin,...
关键词：GLOMERULONEPHRITIS IGA toll-like receptor 4 myeloid differentiation factor 88 NF-kappa B signal transduction inflammation renal fibrosis modified Huangqi Chifeng decoction 
Efficacy of Jiangzhi Xiaoban tablet(降脂消斑片)on toll-like receptor 4/nuclear factor-kappa B/nod-like receptor protein 3 signaling pathway in mice with atherosclerosis induced by high-fat diet
《Journal of Traditional Chinese Medicine》2024年第1期88-94,共7页LIU Huihui FENG Jun LIU Jianhe CHENG Choufu HU Guoheng 
Supported by Youth Fund Project of Hunan Natural Science Foundation Committee:to Explore the Protective Effect of Chaihu Sanshen Capsule on Myocardial Ischemia Reperfusion Injury Based on Iron Death and Inflammatory Response of Myocardial Cells Induced by Mixed lineage kinase 3 Signaling Pathway(No.2021JJ40419);Project of Traditional Chinese Medicine Administration of Hunan Province:to Explore the Mechanism of the Protective Effect of Chaihu Sanshen Capsule on Myocardial Ischemia Reperfusion Injury based on Micro RNA-145-5p Inhibition of Iron Death and Inflammatory Response of Myocardial Cells Induced by Mixed Lineage Kinase 3 Signaling Pathway(No.B2023019);Project of Health Commission of Hunan Province:to Explore the Mechanism of Chaihu Sanshen Capsule in Reducing Myocardial Ischemia Reperfusion Injury Based on Nuclear Factor Erythroid 2-related Factor 2/Heme Oxygenase-1 Pathway Inhibiting Iron Death of Myocardial Cells(No.2021116001377);Project of Hunan University of Chinese Medicine:To Explore the Intervention Effect of Zhenwu Decoction on the Model of Heart and Kidney Yang Deficiency in Rats with Cardiorenal Syndrome through Micro RNA-214/Receptor-interacting Protein Kinase 1-mediated Tumor Necrosis Factor Signal Pathway(No.2020XJJJ038)。
OBJECTIVE:To study the effect of Jiangzhi Xiaoban tablet(降脂消斑片,JZXB)on toll-like receptor 4(TLR4)/nuclear factor-kappa B(NF-κB)/Nod-like receptor protein 3(NLRP3)signaling pathway expression in atherosclerosis(A...
关键词：ATHEROSCLEROSIS toll-like receptor 4 NF-kappa B NLR proteins signal transduction INFLAMMATION Jiangzhi Xiaoban tablet 
Taohong Siwu decoction(桃红四物汤)ameliorates atherosclerosis in rats possibly through toll-like receptor 4/myeloid differentiation primary response protein 88/nuclear factor-κB signal pathway被引量：1
《Journal of Traditional Chinese Medicine》2024年第1期103-112,共10页CHANG Fengjin ZHOU Peng LI Guoying ZHANG Weizhi ZHANG Yanyan PENG Daiyin CHEN Guangliang 
Supported by the National Natural Science Foundation of China:Investigating the Mechanism of Total Saponins in Treating Gouty Arthritis Based on Toll-like Receptor/Myeloid Differentiation Factor 88/Nuclear Factor-Kappa B Signal Pathway and Nacht Leucine-Rich Repeat Protein 3-Inflammasome(No.81573670);Study on the Material Basis and Pathway of Taohong Siwu Decoction in Regulating the Release of Platelet Alpha Granules in Postpartum Blood Stasis(No.81473387);Study on the Regulatory Mechanism of Taohong Siwu Decoction on Experimental Cerebral Ischemia Angiogenesis Based on the Messenger Effect of Platelet Microparticles(No.81503291);Investigating the Material Basis and Molecular Mechanism of Taohong Siwu Decoction Against Vascular Dementia Based on Microdialysis Technology and NOD-Like Receptor Protein 3 Inflammasome Vascular Endothelial Cell Interaction(No.81903953);the Anhui Province Key Research and Development Program:Research on the Development and Preparation of Taohong Siwu Granules(No.1704a0802141)。
OBJECTIVE:To investigate the effect of Taohong Siwu decoction(桃红四物汤,TSD)on atherosclerosis in rats as well as investigate the underlying mechanism based on molecular docking.METHODS:Sixty healthy male Sprague-Daw...
关键词：ATHEROSCLEROSIS molecular docking simulation tolllike receptor 4 myeloid differentiation factor 88 NF-kappa B signal transduction Taohong Siwu decoction 
Efficacy of Ganshuang granules(肝爽颗粒)on non-alcoholic fatty liver and underlying mechanism:a network pharmacology and experimental verification
《Journal of Traditional Chinese Medicine》2024年第1期122-130,共9页ZHI Guoguo SHAO Bingjie ZHENG Tianyan JI Shaoxiu LI Jingwei DANG Yanni LIU Feng WANG Dong 
the Chengdu University of Traditional Chinese Medicine:Application of A Mouse Model to Explore the Mechanism of Therapeutic Action of Safranin in Type 2 Diabetes Mellitus(No.YXRC2018003)。
OBJECTIVE:To investigate the potential pharmacological mechanisms of Ganshuang granules(肝爽颗粒,GSG)in treating non-alcoholic fatty liver(NAFLD).METHODS:All the active components and targets of GSG were retrieved fro...
关键词：fatty liver ALCOHOLIC network pharmacology models ANIMAL phosphatidylinositol 3-kinase proto-oncogene proteins c-akt signal transduction Ganshuang granules 
Bornyl acetate extracted from Sharen(Fructus Amomi)inhibits proliferation,invasion and induces apoptosis by suppressing phosphatidylinositol-3-kinase/protein kinase B signaling in colorectal cancer被引量：2
《Journal of Traditional Chinese Medicine》2023年第6期1081-1091,共11页LI Xiaohua DUAN Zhihang YUE Jianjun ZHANG Yongyu LI Yihang LIU Shifang NIE Qu YANG Depo ZHANG Lixia 
National Key R&D Program of China:Underground Ecological Planting Technology and Base Establishment of Sharen (Fructus Amomi) in the forest (2017YFC1701102);West Yunnan University of Applied Sciences University-level Engineering Research Center projects:Characteristic Dai-Medicine Resource ERC of West Yunnan University of Apllied Science (2022KYPT0004);National Natural Science Foundation of China:Study on the symbiotic system of Sharen (Fructus Amomi);weevil pollination and its "push-pull" pollination mechanism (82260736);Yunnan key labotatory of southern medicine utilization:Major Science and Technology Special Plan of Yunnan Province (202102AA100020);Scientific and Technological Talents and Platform Plan of Yunnan Province (202105AG070011)
OBJECTIVE:To investigate the antitumor effects of bornyl acetate(BA)isolated from Sharen(Fructus Amomi)in colorectal cancer(CRC)and the underlying mechanisms.METHODS:SW480 and HT29 cells were treated with increasing d...
关键词：bornyl acetate colorectal neoplasms phosphatidylinositol 3-kinase protein kinases B signal transduction 
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