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SOD1: 作品数：154被引量：340H指数：9; 导出分析报告; 相关领域：医药卫生更多>>; 相关作者：刘长林陈杰梁毅陈建雄李旭东更多>>; 相关机构：华中师范大学河北医科大学河北医科大学第二医院武汉大学更多>>; 相关期刊：更多>>; 相关基金：国家自然科学基金广东省自然科学基金山东省自然科学基金博士科研启动基金更多>>

Multifaceted superoxide dismutase 1 expression in amyotrophic lateral sclerosis patients:a rare occurrence?: 《Neural Regeneration Research》2025年第1期130-138,共9页Ilaria Martinelli Jessica Mandrioli Andrea Ghezzi Elisabetta Zucchi Giulia Gianferrari Cecilia Simonini Francesco Cavallieri Franco Valzania; Amyotrophic lateral sclerosis(ALS)is a neuromuscular condition resulting from the progressive degeneration of motor neurons in the cortex,brainstem,and spinal cord.While the typical clinical phenotype of ALS involves ...; 关键词：amyotrophic lateral sclerosis(ALS) AUTONOMIC extramotor GENOTYPE-PHENOTYPE multisystem involvement Parkinson’s disease sensory SOD1 superoxide dismutase 1 URINARY vocal cord palsy

5-Hydroxytryptamine:a potential therapeutic target in amyotrophic lateral sclerosis被引量：2: 《Neural Regeneration Research》2023年第9期2047-2055,共9页Shi-Shi Jiang Meng-Ni Gong Wei Rao Wen Chai Wen-Zhi Chen Xiong Zhang Hong-Bing Nie Ren-Shi Xu; supported by the National Natural Science Foundation of China,Nos.30560042,81160161,81360198;82160255;Education Department of Jiangxi Province,Nos.GJJ13198 and GJJ170021;Jiangxi Provincial Department of Science and Technology,Nos.20142BBG70062,20171 BAB215022,20192BAB205043;Health and Family Planning Commission of Jiangxi Province,No.20181019 (all to RSX)。; Previous studies have indicated that the pathogenesis of amyotrophic lateral sclerosis(ALS) is closely linked to 5-hydroxytryptamine(5-HT).To investigate this further,we administered 5-HT receptor antagonists to SOD1*...; 关键词：5-HYDROXYTRYPTAMINE amyotrophic lateral sclerosis ASTROCYTES GRANISETRON MICROGLIA neuron piboserod RITANSERIN SOD1-G93A TAR DNA-binding protein 43

A candidate protective factor in amyotrophic lateral sclerosis:heterogenous nuclear ribonucleoprotein G被引量：2: 《Neural Regeneration Research》2023年第7期1527-1534,共8页Fang Yang Wen-Zhi Chen Shi-Shi Jiang Xiao-Hua Wang Ren-Shi Xu; supported by the National Natural Science Foundation of China,Nos.30560042,81160161,81360198,82160255;Education Department of Jiangxi Province,Nos.GJJ13198 and GJJ170021;Jiangxi Provincial Department of Science and Technology,Nos.[2014]-47,20142BBG70062,20171BAB215022,20192BAB205043;Health and Family Planning Commission of Jiangxi Province,No.20181019(all to RSX).; Heterogenous nuclear ribonucleoprotein G is down-regulated in the spinal cord of the Tg(SOD1*G93A)1Gur(TG)amyotrophic lateral sclerosis mouse model.However,most studies have only examined heterogenous nuclear ribonucl...; 关键词：amyotrophic lateral sclerosis Bax heterogenous nuclear ribonucleoprotein G heterogenous nuclear ribonucleoprotein G-siRNA neuron death superoxide dismutase 1 TAR DNA binding protein 43 TG(SOD1*G93A)1Gur mice

Strategies to promote the maturation of ALS-associated SOD1 mutants: small molecules return to the fold: 《Neural Regeneration Research》2019年第9期1511-1512,共2页Luke McAlary Justin J.Yerbury; (Cu)^IIATSM(CuATSM)promotes the proper folding of familial amyotrophic lateral sclerosis(fALS)-associated copper,zinc superoxide dismutase(SOD1):ALS is a progressive neurodegenerative disease that affects motor neuron...; 关键词：(Cu)^IIATSM(CuATSM) FAMILIAL amyotrophic patient tissue

DNA plasticity and damage in amyotrophic lateral sclerosis被引量：1: 《Neural Regeneration Research》2018年第2期173-180,共8页Diane Penndorf Otto W.Witte Alexandra Kretz; supported by the Ministry for Economics,Sciences and Digital Society of Thuringia(TMWWDG),in the framework of the Pro Excellence Initiative Regener Aging(Regener Aging-FSU-I-03/14 to AK);the Interdisciplinary Center for Clinical Research(IZKF)Jena(Project FF01 to AK); The pathophysiology of amyotrophic lateral sclerosis （ALS） is particularly challenging due to the heteroge- neity of its clinical presentation and the diversity of cellular, molecular and genetic peculiarities invol...; 关键词：amyotrophic lateral sclerosis DNA damage and repair extrachromosomal circular DNA microDNA nuclear pore complex SOD1 mutations TDP-43 pathology transposable elements

Locomotor analysis identifies early compensatory changes during disease progression and subgroup classification in a mouse model of amyotrophic lateral sclerosis被引量：3: 《Neural Regeneration Research》2017年第10期1664-1679,共16页Melissa M.Haulcomb Rena M.Meadows Whitney M.Miller Kathryn P.Mc Millan Me Kenzie J.Hilsmeyer Xuefu Wang Wesley T.Beaulieu Stephanie L.Dickinson Todd J.Brown Virginia M.Sanders Kathryn J.Jones; supported by a grant from National Institute of Health(NIH);Grant No.NS040433; Amyotrophic lateral sclerosis is a motoneuron degenerative disease that is challenging to diagnose and presents with considerable variability in survival.Early identification and enhanced understanding of symptomatic ...; 关键词：nerve regeneration amyotrophic lateral sclerosis motoneuron degenerative disease locomotor disease progression disease variability SOD1 mouse neural regeneration

Mitochondrial quality control in amyotrophic lateral sclerosis：towards a common pathway？被引量：5: 《Neural Regeneration Research》2017年第7期1052-1061,共10页Bilal Khalil Jean-Charles Liévens; Amyotrophic lateral sclerosis（ALS）is a devastating neurodegenerative disorder characterized by loss of upper and lower motor neurons.Different mechanisms contribute to the disease initiation and progression,includin...; 关键词：C9orf72 FUS SOD1 OPTINEURIN PARKIN PGC-1α PINK1 TDP-43 proteinopathies TBK1 VCP

A tale of motor neurons and CD4＋ T cells： moving forward by looking back被引量：1: 《Neural Regeneration Research》2017年第4期562-565,共4页Abhirami Kannan Iyer Kathryn J.Jones; supported by grants from NIH/NINDS R01 funding NS40433; Amyotrophic lateral sclerosis （ALS） is a fatal progressive disorder characterized by the selective degeneration of motor neurons （MN）. The impact of peripheral immune status on disease progression and MN survival ...; 关键词：amyotrophic lateral sclerosis （ALS） superoxide dismutase 1 （SOD1） immune system SOD1 mice motor neuron CD4＋ T cells NEUROPROTECTION

Adenosine monophosphate-activated protein kinase activation enhances embryonic neural stem cell apoptosis in a mouse model of amyotrophic lateral sclerosis被引量：3: 《Neural Regeneration Research》2014年第19期1770-1778,共9页Yanling Sui Zichun Zhao Rong Liu Bin Cai Dongsheng Fan; supported by a grant from the National Natural Sciences Foundation of China,No.81030019; Alterations in embryonic neural stem cells play crucial roles in the pathogenesis of amyotrophic lateral sclerosis. We hypothesized that embryonic neural stem cells from SOD1G93A individuals might be more susceptible ...; 关键词：nerve regeneration neuroderegeneration embryonic neural stem cells adenosine mo-nophosphate-activated protein kinase a paired box 3 p53 SOD1~93A mouse amyotrophic lateralsclerosis oxidative stress hydrogen peroxide APOPTOSIS NSFC grants neural regeneration

Autophagic induction of amyotrophic lateral sclerosislinked Cu/Zn superoxide dismutase 1 G93A mutant in NSC34 cells被引量：1: 《Neural Regeneration Research》2014年第1期16-24,共9页Yanming Wei; supported in part by an Oversea Study Fellowship from the China Scholarship Council,No.2008630089; Previous studies have confirmed that the beclin 1 complex plays a key role in the initial stage of autophagy and deregulated autophagy might involve in amyotrophic lateral sclerosis. However, the mechanism underlying ...; 关键词：nerve regeneration neurodegeneration autophagy amyotrophic lateral sclerosis aggre-gates SOD1 G93A mutant beclin 1 beclin 1 interacting proteins NSC34 cells Oversea Study Fel-lowship from the China Scholarship Council neural regeneration

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